Skip to main content
SpringerLink
Log in

Effects of Selenium Deficiency on Principal Indexes of Chicken Kidney Function

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Selenium (Se) deficiency leads to many pathological changes in animals. However, there have been very few reports regarding chicken tissue injury in the kidney caused by Se deficiency. In this study, a chicken Se-deficient disease model has been constructed, and two renal function indexes [including creatinine (CREA) and uric acid (URIC)], seven renal antioxidative function indexes [including glutathione peroxidase (GPx), anti-hydroxyl radical (AHR), catalase (CAT), hydrogen peroxide (H2O2), nitrogen monoxide (NO), glutathione (GSH), and malonyldialdehyde (MDA)], and two organ/tissue injury-related indexes [including inducible nitric oxide synthase (iNOS) and inducible heme oxygenase (HO)-1] were detected and analyzed to investigate the effects of Se deficiency on chicken kidney tissue. The results showed that Se deficiency caused a significant increase in CREA and URIC levels and a decrease in renal antioxidative capacity. Meanwhile, Se deficiency upregulated the expression of organ/tissue injury-related genes, such as the messenger RNA (mRNA) of HO-1 and iNOS as well as their protein expression levels, in the chicken kidney tissue. These data suggest that Se deficiency in birds triggers renal function regression and oxidative stress in the kidney tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Roman M, Jitaru P, Barbante C (2014) Selenium biochemistry and its role for human health. Metallomics 6:25–54

    Article  CAS  PubMed  Google Scholar 

  2. Rederstorff M, Krol A, Lescure A (2006) Understanding the importance of selenium and selenoproteins in muscle function. Cell Mol Life Sci 63:52–59

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Yao HD, Wu Q, Zhang ZW et al (2013) Selenoprotein W serves as an antioxidant in chicken myoblasts. Biochim Biophys Acta 1830:3112–3120

    Article  CAS  PubMed  Google Scholar 

  4. Yao HD, Wu Q, Zhang ZW et al (2013) Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of Se-deficient chicks. J Nutr 143:613–619

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Zhang JL, Zhang ZW, Shan AS et al (2014) Effects of dietary selenium deficiency or excess on gene expression of selenoprotein N in chicken muscle tissues. Biol Trace Elem Res 157:234–241

    Article  CAS  PubMed  Google Scholar 

  6. Rees K, Hartley L, Day C et al (2013) Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 1:CD009671

    PubMed  Google Scholar 

  7. Iglesias P, Selgas R, Romero S et al (2013) Selenium and kidney disease. J Nephrol 26:266–272

    Article  CAS  PubMed  Google Scholar 

  8. Nagy DT, Fülesdi B, Hallay J (2013) The relationship between selenium and gastrointestinal inflammatory diseases. Orv Hetil 154:1636–1640

    Article  PubMed  Google Scholar 

  9. Liu CP, Fu J, Lin SL et al (2014) Effects of dietary selenium deficiency on mRNA levels of twenty-one selenoprotein genes in the liver of layer chicken. Biol Trace Elem Res 159:192–198

    Article  CAS  PubMed  Google Scholar 

  10. Wu Q, Yao HD, Tan SR et al (2014) Possible correlation of selenoprotein w with inflammation factors in chicken skeletal muscles. Biol Trace Elem Res 161:167–172

    Article  CAS  PubMed  Google Scholar 

  11. Zhang ZW, Wang QH, Zhang JL et al (2012) Effects of oxidative stress on immunosuppression induced by selenium deficiency in chickens. Biol Trace Elem Res 149:352–361

    Article  CAS  PubMed  Google Scholar 

  12. Kiss I (2013) Importance of selenium homeostasis in chronic and end-stage kidney diseases. Orv Hetil 154:1641–1647

    Article  PubMed  Google Scholar 

  13. Naito Y, Takagi T, Higashimura Y (2014) Heme oxygenase-1 and anti-inflammatory M2 macrophages. Arch Biochem Biophys 564:83–88

    Article  CAS  PubMed  Google Scholar 

  14. Nath KA (2014) Heme oxygenase-1 and acute kidney injury. Curr Opin Nephrol Hypertens 23:17–24

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Liao YF, Zhu W, Li DP et al (2013) Heme oxygenase-1 and gut ischemia/reperfusion injury: a short review. World J Gastroenterol 9:3555–3561

    Article  Google Scholar 

  16. Hoffman RA, Mahidhara RS, Wolf-Johnston AS et al (2002) Differential modulation of CD4 and CD8 T-cell proliferation by induction of nitric oxide synthesis in antigen presenting cells. Transplantation 74:836–845

    Article  CAS  PubMed  Google Scholar 

  17. Sakaguchi S, Iizuka Y, Furusawa S et al (2000) Roles of selenium in endotoxin-induced lipid peroxidation in the rats liver and in nitric oxide production in J774A.1 cells. Toxicol Lett 118:69–77

    Article  CAS  PubMed  Google Scholar 

  18. Leone AM, Palmer RM, Knowles RG et al (1991) Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. J Biol Chem 266:23790–23795

    CAS  PubMed  Google Scholar 

  19. Zhao X, Yao H, Fan R et al (2014) Selenium deficiency influences nitric oxide and selenoproteins in pancreas of chickens. Biol Trace Elem Res 161:341–349

    Article  CAS  PubMed  Google Scholar 

  20. Hillyer JF, Estevez-Lao TY (2010) Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria. Dev Comp Immunol 34:141–149

    Article  CAS  PubMed  Google Scholar 

  21. Rivero A (2006) Nitric oxide: an antiparasitic molecule of invertebrates. Trends Parasitol 22:219–225

    Article  CAS  PubMed  Google Scholar 

  22. Chen X, Yao H, Yao L et al (2014) Selenium deficiency influences the gene expressions of heat shock proteins and nitric oxide levels in neutrophils of broilers. Biol Trace Elem Res 161:334–340

    Article  CAS  PubMed  Google Scholar 

  23. Wahlqvist ML (2013) Antioxidant relevance to human health. Asia Pac J Clin Nutr 22:171–176

    CAS  PubMed  Google Scholar 

  24. Najafi M (2014) Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury. World J Cardiol 6:1006–1021

    Article  PubMed Central  PubMed  Google Scholar 

  25. Thomas ME, Blaine C, Dawnay A et al (2014) The definition of acute kidney injury and its use in practice. Kidney Int. doi:10.1038/ki.2014.328

    Google Scholar 

  26. Otterbein LE, Choi AM (2000) Heme oxygenase: colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol 279:L1029–L1037

    CAS  PubMed  Google Scholar 

  27. Palmer RM, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526

    Article  CAS  PubMed  Google Scholar 

  28. Stuehr DJ, Nathan CF (1989) Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 169:1543–1555

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was partially supported by the China Postdoctoral Science Foundation (Grant No. 20110491022) and the Postdoctoral Science Foundation of Heilongjiang Province (Grant No. LBH-Z11230).

Conflict of Interest

The authors declare that there were no conflicts of interest.

Author information

Authors and Affiliations

  1. College of Veterinary Medicine, Northeast Agricultural University, No. 59 Mucai Street, Xiangfang District, 150030, Harbin, People’s Republic of China

    Dongbo Sun, Shu Li & Hongbin Wang

  2. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, No. 2 Xinyang Road, Sartu District, 163319, Daqing, People’s Republic of China

    Dongbo Sun, Chunqiu Li & Jing Gao

Authors
  1. Dongbo Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chunqiu Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jing Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shu Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hongbin Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Shu Li or Hongbin Wang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sun, D., Li, C., Gao, J. et al. Effects of Selenium Deficiency on Principal Indexes of Chicken Kidney Function. Biol Trace Elem Res 164, 58–63 (2015). https://doi.org/10.1007/s12011-014-0196-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-014-0196-0

Keywords

Search

Navigation