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Predictors of Transition to Psychosis in Individuals at Clinical High Risk

  • Precision Medicine in Psychiatry (S Kennedy, Section Editor)
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Abstract

Purpose of Review

Current research is examining predictors of the transition to psychosis in youth who are at clinical high risk based on attenuated psychotic symptoms (APS). Determining predictors of the development of psychosis is important for an improved understanding of mechanisms as well as the development of preventative strategies. The purpose is to review the most recent literature identifying predictors of the transition to psychosis in those who are already assessed as being at risk.

Recent Findings

Multidomain models, in particular, integrated models of symptoms, social functioning, and cognition variables, achieve better predictive performance than individual factors. There are many methodological issues; however, several solutions have now been described in the literature.

Summary

For youth who already have APS, predicting who may go on to later develop psychosis is possible. Several studies are underway in large consortiums that may overcome some of the methodological concerns and develop improved means of prediction.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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Acknowledgments

Preparation of this article was supported by National Institute of Mental Health Grant MH081984 to Jean Addington. Paul Metzak and Olga Santesteban-Echarri are supported by Canadian Institutes of Health Research post-doctoral scholarships.

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Authors and Affiliations

  1. Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada

    Jean Addington, Megan Farris, Jacqueline Stowkowy, Olga Santesteban-Echarri, Paul Metzak & Mohammed Shakeel Kalathil

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Correspondence to Jean Addington.

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Addington, J., Farris, M., Stowkowy, J. et al. Predictors of Transition to Psychosis in Individuals at Clinical High Risk. Curr Psychiatry Rep 21, 39 (2019). https://doi.org/10.1007/s11920-019-1027-y

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