Abstract
Purpose of Review
Traumatic neuromas in general, and trigeminal traumatic neuromas in particular, are relatively rare entities originating from a damage to a corresponding nerve or its branches. This manuscript is a comprehensive review of the literature on trigeminal traumatic neuromas based on an interesting and challenging case of bilateral intraoral lesions.
Recent Findings
The diagnosis for this patient was bilateral trigeminal traumatic neuromas. It is possible that these patients have a genetic predisposition to the development of these lesions. It is a neuropathic pain condition and may mimic dental and other trigeminal pain entities. Topical treatment with lidocaine gel, utilizing a custom-made neurosensory stent, rendered the patient significant and sustained pain relief.
Summary
Trigeminal traumatic neuromas present a diagnostic challenge even to a seasoned clinician, due to the complex clinical features that may mimic other entities. Topical medications such as local anesthetics may be a good viable alternative to systemic medications to manage the pain associated with the condition. Early identification of the lesion and the associated pain helps in the succinct management of symptomatic trigeminal traumatic neuromas.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Oliveira KMC, Pindur L, Han Z, Bhavsar MB, Barker JH, Leppik L. Time course of traumatic neuroma development. PLoS ONE. 2018;13(7):e0200548.
• Khan J, Noboru N, Young A, Thomas D. Pro and anti-inflammatory cytokine levels (TNF-α, IL-1β, IL-6 and IL-10) in rat model of neuroma Pathophysiology 2017;24(3):155–159. https://doi.org/10.1016/j.pathophys.2017.04.001. Article describing the gross and histologic appearance of an experimentally induced traumatic neuroma, that is confirmed by histopathology.
• Ananthaneni A, Srilekha N, Guduru VS, Kiresur MA. Rare case report of traumatic neuroma of anterior superior alveolar nerve associated with high frenal attachment Asian J Neurosurg. 2015;10(2):169–171. https://doi.org/10.4103/1793-5482.153502. Article describing the classic appearance and features of a trigeminal traumatic neuroma, and giving guidance as to how to avoid misdiagnosis.
Ngamsom S, Nakamura S, Kabasawa Y, Harada H, Tohyama R, Kurabayashi T. Imaging findings of intraosseous traumatic neuroma of the mandible. Oral Radiol. 2018;34(3):257–61. https://doi.org/10.1007/s11282-017-0286-8.
Tashiro A, Imafuku S, Furue M. Traumatic neuroma of the lower lip with intraepithelial nerve fibers. J Cutan Pathol. 2008;35(3):320–3. https://doi.org/10.1111/j.1600-0560.2007.00801.x.
Eguchi T, Ishida R, Ara H, Hamada Y, Kanai I. A diffuse traumatic neuroma in the palate: a case report. J Med Case Rep. 2016;10(1):116. https://doi.org/10.1186/s13256-016-0908-5.
Jaafari Ashkavandi Z, Dehghani Nazhvani A, Hamzavi M. Mucocele accompanied by a traumatic neuroma: a case report. J Dent (Shiraz). 2013;14(1):46–8.
Swanson HH. Traumatic neuromas. A review of the literature. Oral Surg Oral Med Oral Pathol. 1961;14:317–26. https://doi.org/10.1016/0030-4220(61)90297-3.
Nakanishi T, Yamamoto Y, Tanioka K, Shintani Y, Tojyo I, Fujita S. Effect of duration from lingual nerve injury to undergoing microneurosurgery on improving sensory and taste functions: retrospective study. Maxillofac Plast Reconstr Surg. 2019;41(1):61. https://doi.org/10.1186/s40902-019-0244-y.
Al-Sabbagh M, Okeson JP, Khalaf MW, Bhavsar I. Persistent pain and neurosensory disturbance after dental implant surgery: pathophysiology, etiology, and diagnosis. Dent Clin North Am. 2015;59(1):131–42. https://doi.org/10.1016/j.cden.2014.08.004.
Terumitsu M, Matsuzawa H, Seo K, Watanabe M, Kurata S, Suda A, et al. High-contrast high-resolution imaging of posttraumatic mandibular nerve by 3DAC-PROPELLER magnetic resonance imaging: correlation with the severity of sensory disturbance. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(1):85–94. https://doi.org/10.1016/j.oooo.2017.02.017.
Ulivieri S, Muscas G, Miracco C, Oliveri G, Galluzzi P, Giorgio A. Unusual case of traumatic neuroma of the orbit. Orbit. 2016;35(2):62–5. https://doi.org/10.3109/01676830.2015.1099703.
Foltán R, Klíma K, Spacková J, Sedý J. Mechanism of traumatic neuroma development. Med Hypotheses. 2008;71(4):572–6. https://doi.org/10.1016/j.mehy.2008.05.010.
Arribas-García I, Alcalá-Galiano A, Gutiérrez R, Montalvo-Moreno JJ. Traumatic neuroma of the inferior alveolar nerve: a case report. Med Oral Patol Oral Cir Bucal. 2008;13(3):E186–8.
Alant JD, Kemp SW, Khu KJ, Kumar R, Webb AA, Midha R. Traumatic neuroma in continuity injury model in rodents. J Neurotrauma. 2012;29(8):1691–703. https://doi.org/10.1089/neu.2011.1857.
Weng W, Zhao B, Lin D, Gao W, Li Z, Yan H. Significance of alpha smooth muscle actin expression in traumatic painful neuromas: a pilot study in rats. Sci Rep. 2016;6:23828. https://doi.org/10.1038/srep23828.
Mavrogenis AF, Pavlakis K, Stamatoukou A, Papagelopoulos PJ, Theoharis S, Zoubos AB, et al. Current treatment concepts for neuromas-in-continuity. Injury. 2008;39(Suppl 3):S43–8. https://doi.org/10.1016/j.injury.2008.05.015.
Peszkowski MJ, Larsson A. Extraosseous and intraosseous oral traumatic neuromas and their association with tooth extraction. J Oral Maxillofac Surg. 1990;48(9):963–7. https://doi.org/10.1016/0278-2391(90)90010-y.
Rasmussen OC. Painful traumatic neuromas in the oral cavity. Oral Surg Oral Med Oral Pathol. 1980;49(3):191–5. https://doi.org/10.1016/0030-4220(80)90043-2.
Lopes MA, Vargas PA, Almeida OP, Takahama A, León JE. Oral traumatic neuroma with mature ganglion cells: a case report and review of the literature. J Oral Maxillofac Pathol. 2009;13(2):67–9. https://doi.org/10.4103/0973-029x.57672.
Ha EJ, Baek JH, Lee JH, Kim YJ, Kim JK, Kim TY, et al. Characteristic ultrasound feature of traumatic neuromas after neck dissection: direct continuity with the cervical plexus. Thyroid. 2012;22(8):820–6. https://doi.org/10.1089/thy.2012.0092.
Ha EJ, Lee JH, Lim HK, Bae Kim W, Baek JH. Identification of continuity of transected nerve on sonography after neck dissection: direct sign of traumatic neuroma. Thyroid. 2011;21(12):1385–7. https://doi.org/10.1089/thy.2011.0207.
Vora AR, Loescher AR, Craig GT, Boissonade FM, Robinson PP. A light microscopical study on the structure of traumatic neuromas of the human lingual nerve. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(4):395–403. https://doi.org/10.1016/j.tripleo.2004.08.011.
Lee EJ, Calcaterra TC, Zuckerbraun L. Traumatic neuromas of the head and neck. Ear Nose Throat J. 1998;77(8):670–4, 6.
Deng W, Chen SL, Huang DY. Traumatic neuroma of mental nerve following chin augmentation. Int J Oral Maxillofac Surg. 2009;38(12):1324–6. https://doi.org/10.1016/j.ijom.2009.06.020.
Kallal RH, Ritto FG, Almeida LE, Crofton DJ, Thomas GP. Traumatic neuroma following sagittal split osteotomy of the mandible. Int J Oral Maxillofac Surg. 2007;36(5):453–4. https://doi.org/10.1016/j.ijom.2006.10.017.
Sayan NB, Uçok C. Asymptomatic traumatic neuroma after mandibular sagittal split osteotomy: a case report. J Oral Maxillofac Surg. 2002;60(1):111–2. https://doi.org/10.1053/joms.2002.29088.
Sist TC, Jr., Greene GW. Traumatic neuroma of the oral cavity. Report of thirty-one new cases and review of the literature. Oral Surg Oral Med Oral Pathol. 1981;51(4):394–402. https://doi.org/10.1016/0030-4220(81)90149-3.
Chau MN, Jönsson E, Lee KM. Traumatic neuroma following sagittal mandibular osteotomy. Int J Oral Maxillofac Surg. 1989;18(2):95–8. https://doi.org/10.1016/s0901-5027(89)80139-0.
Patel SS, Lee BJ, Elner VM. Painful traumatic neuroma after orbital decompression surgery. Arch Ophthalmol. 2012;130(4):530–1. https://doi.org/10.1001/archophthalmol.2011.1560.
Baldeschi L, Saeed P, Regensburg NI, Zacharopoulos I, Wiersinga WM. Traumatic neuroma of the infraorbital nerve subsequent to inferomedial orbital decompression for Graves’ orbitopathy. Eur J Ophthalmol. 2010;20(2):481–4. https://doi.org/10.1177/112067211002000239.
Amjadi S, Chan WO, Rajak S, Morrissey DK, Simon S, Davis G, et al. A case of traumatic infraorbital neuroma. Oral Maxillofac Surg. 2017;21(4):471–3. https://doi.org/10.1007/s10006-017-0658-6.
Freidman RM, Rohrich RJ, Finn SS. Management of traumatic supraorbital neuroma. Ann Plast Surg. 1992;28(6):573–4.
Jham BC, Costa NL, Batista AC, Mendonça EF. Traumatic neuroma of the mandible: a case report with spontaneous remission. J Clin Exp Dent. 2014;6(3):e317–20. https://doi.org/10.4317/jced.51659.
Feng Y, Patel NS, Burrows AM, Lane JI, Raghunathan A, Van Gompel JJ, et al. Expansile traumatic neuroma of the intratemporal facial nerve. J Neurol Surg Rep. 2019;80(1):e10–3. https://doi.org/10.1055/s-0039-1685212.
Yabuuchi H, Kuroiwa T, Fukuya T, Tomita K, Hachitanda Y. Traumatic neuroma and recurrent lymphadenopathy after neck dissection: comparison of radiologic features. Radiology. 2004;233(2):523–9. https://doi.org/10.1148/radiol.2331030779.
Daneshvar A. Pharyngeal traumatic neuromas and traumatic neuromas with mature ganglion cells (pseudoganglioneuromas). Am J Surg Pathol. 1990;14(6):565–70. https://doi.org/10.1097/00000478-199006000-00007.
Tamiolakis P, Chrysomali E, Sklavounou-Andrikopoulou A, Nikitakis NG. Oral neural tumors: clinicopathologic analysis of 157 cases and review of the literature. J Clin Exp Dent. 2019;11(8):e721–31. https://doi.org/10.4317/jced.55944.
Salla JT, Johann AC, Garcia BG, Aguiar MC, Mesquita RA. Retrospective analysis of oral peripheral nerve sheath tumors in Brazilians. Braz Oral Res. 2009;23(1):43–8. https://doi.org/10.1590/s1806-83242009000100008.
Chrysomali E, Papanicolaou SI, Dekker NP, Regezi JA. Benign neural tumors of the oral cavity: a comparative immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84(4):381–90. https://doi.org/10.1016/s1079-2104(97)90036-6.
Kretschmer T, Nguyen DH, Beuerman RW, Happel LT, England JD, Tiel RL, et al. Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. J Neurosurg. 2002;97(6):1424–31. https://doi.org/10.3171/jns.2002.97.6.1424.
Harpf C, Dabernig J, Humpel C. Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma. Muscle Nerve. 2002;25(4):612–5. https://doi.org/10.1002/mus.10103.
Bongenhielm U, Nosrat CA, Nosrat I, Eriksson J, Fjell J, Fried K. Expression of sodium channel SNS/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat. Exp Neurol. 2000;164(2):384–95. https://doi.org/10.1006/exnr.2000.7437.
Neumeister MW, Winters JN. Neuroma. Clin Plast Surg. 2020;47(2):279–83. https://doi.org/10.1016/j.cps.2019.12.008.
Ahlawat S, Belzberg AJ, Montgomery EA, Fayad LM. MRI features of peripheral traumatic neuromas. Eur Radiol. 2016;26(4):1204–12. https://doi.org/10.1007/s00330-015-3907-9.
Kodama Y, Seo K, Hayashi T, Kobayashi T, Niwano M, Koyama T, et al. Orofacial pain related to traumatic neuroma in a patient with multiple TMJ operations. Cranio. 2012;30(3):183–7. https://doi.org/10.1179/crn.2012.028.
Huang LF, Weissman JL, Fan C. Traumatic neuroma after neck dissection: CT characteristics in four cases. AJNR Am J Neuroradiol. 2000;21(9):1676–80.
Vorobeichik L, Fallucco MA, Hagan RR. Chronic daily headaches secondary to greater auricular and lesser occipital neuromas following endolymphatic shunt surgery. BMJ Case Rep. 2012;2012. https://doi.org/10.1136/bcr-2012-007189.
Argenyi ZB, Santa Cruz D, Bromley C. Comparative light-microscopic and immunohistochemical study of traumatic and palisaded encapsulated neuromas of the skin. Am J Dermatopathol. 1992;14(6):504–10. https://doi.org/10.1097/00000372-199212000-00003.
Koutlas IG, Scheithauer BW. Palisaded encapsulated (“solitary circumscribed”) neuroma of the oral cavity: a review of 55 cases. Head Neck Pathol. 2010;4(1):15–26. https://doi.org/10.1007/s12105-010-0162-x.
Arnold DMJ, Wilkens SC, Coert JH, Chen NC, Ducic I, Eberlin KR. Diagnostic criteria for symptomatic neuroma. Ann Plast Surg. 2019;82(4):420–7. https://doi.org/10.1097/sap.0000000000001796.
Ramsook RR, Spinner D. Ultrasound-guided cryoablation of a traumatic hip disarticulation neuroma. Pain Pract. 2017;17(7):941–4. https://doi.org/10.1111/papr.12534.
Dahlin LB, Wiberg M. Nerve injuries of the upper extremity and hand. EFORT Open Rev. 2017;2(5):158–70. https://doi.org/10.1302/2058-5241.2.160071.
Wajid H, LeBlanc J, Shapiro DB, Delzell PB. Bowler’s thumb: ultrasound diagnosis of a neuroma of the ulnar digital nerve of the thumb. Skeletal Radiol. 2016;45(11):1589–92. https://doi.org/10.1007/s00256-016-2469-5.
Stokvis A, Coert JH. Operative treatment of painful neuromas. Ned Tijdschr Geneeskd. 2011;155(18):A2592.
Martin A, Perinetti G, Costantinides F, Maglione M. Coronectomy as a surgical approach to impacted mandibular third molars: a systematic review. Head Face Med. 2015;11:9. https://doi.org/10.1186/s13005-015-0068-7.
MacIntosh RB. Experience with the sagittal osteotomy of the mandibular ramus: a 13-year review. J Maxillofac Surg. 1981;9(3):151–65. https://doi.org/10.1016/s0301-0503(81)80036-7.
Brusati R, Fiamminghi L, Sesenna E, Gazzotti A. Functional disturbances of the inferior alveolar nerve after sagittal osteotomy of the mandibular ramus: operating technique for prevention. J Maxillofac Surg. 1981;9(2):123–5. https://doi.org/10.1016/s0301-0503(81)80028-8.
Fiamminghi L, Aversa C. Lesions of the inferior alveolar nerve in sagittal osteotomy of the ramus – experimental-study. J Maxillofac Surg. 1979;7(2):125–8. https://doi.org/10.1016/s0301-0503(79)80024-7.
Meek MF, Coert JH, de Visscher JG. Re: Renton T, Hankins M, Sproate C, McGurk M. A randomised controlled clinical trial to compare the incidence of injury to the inferior alveolar nerve as a result of coronectomy and removal of mandibular third molars. Br J Oral Maxillofac Surg 2005;43(4):7–12, 2006;44(1):75–6; author reply 6–7. https://doi.org/10.1016/j.bjoms.2005.03.029.
Renton T, Hankins M, Sproate C, McGurk M. A randomised controlled clinical trial to compare the incidence of injury to the inferior alveolar nerve as a result of coronectomy and removal of mandibular third molars. Br J Oral Maxillofac Surg. 2005;43(1):7–12. https://doi.org/10.1016/j.bjoms.2004.09.002.
Aljunid S, AlSiweedi S, Nambiar P, Chai WL, Ngeow WC. The management of persistent pain from a branch of the trifid mandibular canal due to implant impingement. J Oral Implantol. 2016;42(4):349–52. https://doi.org/10.1563/aaid-joi-D-16-00011.
Palma-Carrió C, Balaguer-Martínez J, Peñarrocha-Oltra D, Peñarrocha-Diago M. Irritative and sensory disturbances in oral implantology. Literature review. Med Oral Patol Oral Cir Bucal. 2011;16(7):e1043–6. https://doi.org/10.4317/medoral.17125.
Ziccardi VB, Zuniga JR. Nerve injuries after third molar removal. Oral Maxillofac Surg Clin North Am. 2007;19(1):105–15, vii. https://doi.org/10.1016/j.coms.2006.11.005.
Miloro M, Halkias LE, Slone HW, Chakeres DW. Assessment of the lingual nerve in the third molar region using magnetic resonance imaging. J Oral Maxillofac Surg. 1997;55(2):134–7. https://doi.org/10.1016/s0278-2391(97)90228-7.
Tay SC, Teoh LC, Yong FC, Tan SH. The prevention of neuroma formation by diathermy: an experimental study in the rat common peroneal nerve. Ann Acad Med Singap. 2005;34(5):362–8.
Fu T, Lineaweaver WC, Zhang F, Zhang J. Role of shortwave and microwave diathermy in peripheral neuropathy. J Int Med Res. 2019;47(8):3569–79. https://doi.org/10.1177/0300060519854905.
Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367(9522):1618–25. https://doi.org/10.1016/s0140-6736(06)68700-x.
Renton T, Yilmaz Z, Gaballah K. Evaluation of trigeminal nerve injuries in relation to third molar surgery in a prospective patient cohort. Recommendations for prevention. Int J Oral Maxillofac Surg. 2012;41(12):1509–18. https://doi.org/10.1016/j.ijom.2012.06.025.
•• Al-Sabbagh M, Okeson JP, Bertoli E, Medynski DC, Khalaf MW. Persistent pain and neurosensory disturbance after dental implant surgery: prevention and treatment Dent Clin North Am. 2015;59(1):143–156. https://doi.org/10.1016/j.cden.2014.08.005. Cardinal article describing specifically the modalities of management of trigeminal neuropathic pain, the type we see in a case of trigeminal traumatic neuroma.
Brunelli GA. Prevention of damage caused by sural nerve withdrawal for nerve grafting. Hand Surg. 2002;7(2):163–6. https://doi.org/10.1142/s0218810402001138.
Lewin-Kowalik J, Marcol W, Kotulska K, Mandera M, Klimczak A. Prevention and management of painful neuroma. Neurol Med Chir (Tokyo). 2006;46(2):62–7; discussion 7–8. https://doi.org/10.2176/nmc.46.62.
Otfinowski J, Pawelec A, Kałuza J. Implantation of peripheral neural stump into muscle and its effect on the development of posttraumatic neuroma. Pol J Pathol. 1994;45(3):195–202.
Tukel M, Beaulieu R, Kahana A. Resolution of persistent traumatic supraorbital pain after neuroma excision. Orbit. 2020:1–3. https://doi.org/10.1080/01676830.2020.1831025.
Jones MR, Urits I, Ehrhardt KP, Cefalu JN, Kendrick JB, Park DJ, et al. A comprehensive review of trigeminal neuralgia. Curr Pain Headache Rep. 2019;23(10):74. https://doi.org/10.1007/s11916-019-0810-0.
Jakobs M, Unterberg A, Treede RD, Schuh-Hofer S, Ahmadi R. Subcutaneous trigeminal nerve field stimulation for refractory trigeminal pain: a cohort analysis. Acta Neurochir (Wien). 2016;158(9):1767–74. https://doi.org/10.1007/s00701-016-2881-6.
Lalchandani P, Korn A, Lu JG, French SW, Hou L, Chen KT. Traumatic bile duct neuroma presenting with acute cholangitis: a case report and review of literature. Ann Hepatobiliary Pancreat Surg. 2019;23(3):282–5. https://doi.org/10.14701/ahbps.2019.23.3.282.
Kim DH, Park JH, Cho JK, Yang JW, Kim TH, Jeong SH, et al. Traumatic neuroma of remnant cystic duct mimicking duodenal subepithelial tumor: a case report. World J Clin Cases. 2020;8(17):3821–7. https://doi.org/10.12998/wjcc.v8.i17.3821.
Lefemine V, Lazim TR. Neuroma of a double gallbladder: a case report. Cases J. 2009;2(1):11. https://doi.org/10.1186/1757-1626-2-11.
Ducic I, Yoon J. Reconstructive options for inferior alveolar and lingual nerve injuries after dental and oral surgery: an evidence-based review. Ann Plast Surg. 2019;82(6):653–60. https://doi.org/10.1097/sap.0000000000001783.
Curran T, Poylin V, Kane R, Harris A, Goldsmith JD, Nagle D. Case report of a traumatic rectal neuroma. Gastroenterol Rep (Oxf). 2016;4(4):331–3. https://doi.org/10.1093/gastro/gov023.
Modest JM, Raducha JE, Testa EJ, Eberson CP. Management of post-amputation pain. R I Med J (2013). 2020;103(4):19–22.
Gstoettner C, Laengle G, Salminger S, Festin C, Platzgummer H, Aszmann OC. Surgical management of peripheral nerves after extremity loss. Orthopade. 2021;50(1):14–23. https://doi.org/10.1007/s00132-020-04032-1.
Hooper RC, Cederna PS, Brown DL, Haase SC, Waljee JF, Egeland BM, et al. Regenerative peripheral nerve interfaces for the management of symptomatic hand and digital neuromas. Plast Reconstr Surg Glob Open. 2020;8(6): e2792. https://doi.org/10.1097/gox.0000000000002792.
Valerio I, Schulz SA, West J, Westenberg RF, Eberlin KR. Targeted muscle reinnervation combined with a vascularized pedicled regenerative peripheral nerve interface. Plast Reconstr Surg Glob Open. 2020;8(3): e2689. https://doi.org/10.1097/gox.0000000000002689.
Vu PP, Vaskov AK, Irwin ZT, Henning PT, Lueders DR, Laidlaw AT et al. A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees. Sci Transl Med. 2020;12(533). https://doi.org/10.1126/scitranslmed.aay2857.
Létourneau SG, Hendry JM. Managing neuroma and phantom limb pain in Ontario: the status of targeted muscle reinnervation. Plast Reconstr Surg Glob Open. 2020;8(12): e3287. https://doi.org/10.1097/gox.0000000000003287.
Lanier ST, Jordan SW, Ko JH, Dumanian GA. Targeted muscle reinnervation as a solution for nerve pain. Plast Reconstr Surg. 2020;146(5):651e-e663. https://doi.org/10.1097/prs.0000000000007235.
Estifan E, Patel V, Grossman M. Cap-assisted endoscopic mucosal resection of an incidental rectal traumatic neuroma. Case Rep Gastrointest Med. 2019;2019:8328456. https://doi.org/10.1155/2019/8328456.
Khan J, Anwer M, Noboru N, Thomas D, Kalladka M. Topical application in burning mouth syndrome. J Dent Sci. 2019;14(4):352–7. https://doi.org/10.1016/j.jds.2019.04.007.
Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9(8):807–19. https://doi.org/10.1016/s1474-4422(10)70143-5.
Bennett DL. Informed drug choices for neuropathic pain. Lancet Neurol. 2015;14(2):129–30. https://doi.org/10.1016/s1474-4422(14)70329-1.
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162–73. https://doi.org/10.1016/s1474-4422(14)70251-0.
Mendell JR, Sahenk Z. Clinical practice. Painful sensory neuropathy. N Engl J Med. 2003;348(13):1243–55. https://doi.org/10.1056/NEJMcp022282.
Safarpour D, Salardini A, Richardson D, Jabbari B. Botulinum toxin A for treatment of allodynia of complex regional pain syndrome: a pilot study. Pain Med. 2010;11(9):1411–4. https://doi.org/10.1111/j.1526-4637.2010.00897.x.
Khan J. Neuropathic pain. J Indian Prosthodont Soc. 2016;16(2):114–5. https://doi.org/10.4103/0972-4052.179317.
Baad-Hansen L, Benoliel R. Neuropathic orofacial pain: facts and fiction. Cephalalgia. 2017;37(7):670–9. https://doi.org/10.1177/0333102417706310.
Moreno-Hay I, Mishra P, Okeson JP. Intraoral administration of botulinum toxin for continuous dentoalveolar neuropathic pain: a case series. J Oral Facial Pain Headache. 2019;33(2):160–4. https://doi.org/10.11607/ofph.2031.
Cuadrado ML, García-Moreno H, Arias JA, Pareja JA. Botulinum neurotoxin type-a for the treatment of atypical odontalgia. Pain Med. 2016;17(9):1717–21. https://doi.org/10.1093/pm/pnw040.
Xia JH, He CH, Zhang HF, Lian YJ, Chen Y, Wu CJ, et al. Botulinum toxin A in the treatment of trigeminal neuralgia. Int J Neurosci. 2016;126(4):348–53. https://doi.org/10.3109/00207454.2015.1019624.
Zúñiga C, Piedimonte F, Díaz S, Micheli F. Acute treatment of trigeminal neuralgia with onabotulinum toxin A. Clin Neuropharmacol. 2013;36(5):146–50. https://doi.org/10.1097/WNF.0b013e31829cb60e.
Shehata HS, El-Tamawy MS, Shalaby NM, Ramzy G. Botulinum toxin-type A: could it be an effective treatment option in intractable trigeminal neuralgia? J Headache Pain. 2013;14(1):92. https://doi.org/10.1186/1129-2377-14-92.
Porto F, de Leeuw R, Evans DR, Carlson CR, Yepes JF, Branscum A, et al. Differences in psychosocial functioning and sleep quality between idiopathic continuous orofacial neuropathic pain patients and chronic masticatory muscle pain patients. J Orofac Pain. 2011;25(2):117–24.
Ngeow WC, Nair R. Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(3):e47-50. https://doi.org/10.1016/j.tripleo.2009.03.021.
Bohluli B, Motamedi MH, Bagheri SC, Bayat M, Lassemi E, Navi F, et al. Use of botulinum toxin A for drug-refractory trigeminal neuralgia: preliminary report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(1):47–50. https://doi.org/10.1016/j.tripleo.2010.04.043.
Piovesan EJ, Teive HG, Kowacs PA, Della Coletta MV, Werneck LC, Silberstein SD. An open study of botulinum-A toxin treatment of trigeminal neuralgia. Neurology. 2005;65(8):1306–8. https://doi.org/10.1212/01.wnl.0000180940.98815.74.
Salemis NS. Traumatic neuroma as a rare cause of intractable neuropathic breast pain following cancer surgery: management and review of the literature. Intractable Rare Dis Res. 2018;7(3):185–90. https://doi.org/10.5582/irdr.2018.01041.
Kent ML, Hsia HJ, Van de Ven TJ, Buchheit TE. Perioperative pain management strategies for amputation: a topical review. Pain Med. 2017;18(3):504–19. https://doi.org/10.1093/pm/pnw110.
Borghi B, Chierichini R, Tognù A, White PF. Phantom limb pain therapy. Pain Med. 2020;21(10):2600–1. https://doi.org/10.1093/pm/pnaa307.
Wu CL, Agarwal S, Tella PK, Klick B, Clark MR, Haythornthwaite JA, et al. Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial. Anesthesiology. 2008;109(2):289–96. https://doi.org/10.1097/ALN.0b013e31817f4523.
Wu CL, Tella P, Staats PS, Vaslav R, Kazim DA, Wesselmann U, et al. Analgesic effects of intravenous lidocaine and morphine on postamputation pain: a randomized double-blind, active placebo-controlled, crossover trial. Anesthesiology. 2002;96(4):841–8. https://doi.org/10.1097/00000542-200204000-00010.
Yao C, Zhou X, Zhao B, Sun C, Poonit K, Yan H. Treatments of traumatic neuropathic pain: a systematic review. Oncotarget. 2017;8(34):57670–9. https://doi.org/10.18632/oncotarget.16917.
Dahl E, Cohen SP. Perineural injection of etanercept as a treatment for postamputation pain. Clin J Pain. 2008;24(2):172–5. https://doi.org/10.1097/AJP.0b013e31815b32c8.
Padilla M, Clark GT, Merrill RL. Topical medications for orofacial neuropathic pain: a review. J Am Dent Assoc. 2000;131(2):184–95. https://doi.org/10.14219/jada.archive.2000.0146.
Sommer C, Cruccu G. Topical treatment of peripheral neuropathic pain: applying the evidence. J Pain Symptom Manage. 2017;53(3):614–29. https://doi.org/10.1016/j.jpainsymman.2016.09.015.
Khawaja N, Yilmaz Z, Renton T. Case studies illustrating the management of trigeminal neuropathic pain using topical 5% lidocaine plasters. Br J Pain. 2013;7(2):107–13. https://doi.org/10.1177/2049463713483459.
Touchette D, Gessler EM. Painful traumatic neuroma of the tongue treated with serial alcohol injections. Otolaryngol Head Neck Surg. 2011;145(4):699–700. https://doi.org/10.1177/0194599811405292.
•• Devor M, Govrin-Lippmann R, Raber P. Corticosteroids suppress ectopic neural discharge originating in experimental neuromas Pain 1985;22(2):127–137. https://doi.org/10.1016/0304-3959(85)90173-3. Pioneer article describing the effectiveness of topical corticosteroids for management of traumatic neuroma.
Matthews J, Merrill RL. Sodium hypochlorite-related injury with chronic pain sequelae. J Am Dent Assoc. 2014;145(6):553–5. https://doi.org/10.14219/jada.2014.19.
Graff-Radford SB, Evans RW. Lingual nerve injury. Headache. 2003;43(9):975–83. https://doi.org/10.1046/j.1526-4610.2003.03189.x.
Hsu E, Cohen SP. Postamputation pain: epidemiology, mechanisms, and treatment. J Pain Res. 2013;6:121–36. https://doi.org/10.2147/jpr.S32299.
Murphy D, Lester D, Clay Smither F, Balakhanlou E. Peripheral neuropathic pain. NeuroRehabilitation. 2020;47(3):265–83. https://doi.org/10.3233/nre-208002.
Bates D, Schultheis BC, Hanes MC, Jolly SM, Chakravarthy KV, Deer TR, et al. A comprehensive algorithm for management of neuropathic pain. Pain Med. 2019;20(Suppl 1):S2-s12. https://doi.org/10.1093/pm/pnz075.
Leung A, Fallah A, Shukla S. Transcutaneous magnetic stimulation (TMS) in alleviating post-traumatic peripheral neuropathic pain States: a case series. Pain Med. 2014;15(7):1196–9. https://doi.org/10.1111/pme.12426.
Kesikburun S, Yaşar E, Dede I, Göktepe S, Tan AK. Ultrasound-guided steroid injection in the treatment of stump neuroma: pilot study. J Back Musculoskelet Rehabil. 2014;27(3):275–9. https://doi.org/10.3233/bmr-130444.
Zhang X, Xu Y, Zhou J, Pu S, Lv Y, Chen Y, et al. Ultrasound-guided alcohol neurolysis and radiofrequency ablation of painful stump neuroma: effective treatments for post-amputation pain. J Pain Res. 2017;10:295–302. https://doi.org/10.2147/jpr.S127157.
Tokuc B, Altındis S, Coskunses FM, Sinanoglu A. Excision of rare intraosseous traumatic neuroma of the mandible. J Stomatol Oral Maxillofac Surg. 2021;122(2):199–202. https://doi.org/10.1016/j.jormas.2020.08.010.
Sedý J. Traumatic neuroma and scar tissue. Int J Oral Maxillofac Surg. 2010;39(3):310; author reply -1. https://doi.org/10.1016/j.ijom.2009.10.017.
Biggs JE, Yates JM, Loescher AR, Clayton NM, Boissonade FM, Robinson PP. Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain. Brain Res. 2007;1127(1):59–65. https://doi.org/10.1016/j.brainres.2006.10.014.
Giglio JA, Gregg JM. Development of mirror pain following trigeminal nerve injury: a case report and review of neuropathic mechanisms. Gen Dent. 2018;66(1):27–32.
Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 2009.
Yang J-R, Wang C-J, Kao W-B, Wang Y-L. Traumatic neuroma of bilateral mental nerve: a case report with literature review. 臺灣口腔顎面外科學會雜誌. 2010;21(3):252–60.
Chen W, Zhang H, Huang J, Li Y, Zhang Z, Peng Y. Traumatic neuroma in mastectomy scar: Two case reports and review of the literature. Medicine (Baltimore). 2019;98(15): e15142. https://doi.org/10.1097/md.0000000000015142.
AlSharif S, Ferré R, Omeroglu A, El Khoury M, Mesurolle B. Imaging features associated with posttraumatic breast neuromas. AJR Am J Roentgenol. 2016;206(3):660–5. https://doi.org/10.2214/ajr.14.14035.
Li Q, Gao EL, Yang YL, Hu HY, Hu XQ. Traumatic neuroma in a patient with breast cancer after mastectomy: a case report and review of the literature. World J Surg Oncol. 2012;10:35. https://doi.org/10.1186/1477-7819-10-35.
Kang J, Yang P, Zang Q, He X. Traumatic neuroma of the superficial peroneal nerve in a patient: a case report and review of the literature. World J Surg Oncol. 2016;14(1):242. https://doi.org/10.1186/s12957-016-0990-6.
Devor M, Raber P. Heritability of symptoms in an experimental model of neuropathic pain. Pain. 1990;42(1):51–67. https://doi.org/10.1016/0304-3959(90)91092-w.
Robinson M, Slavkin HC. Dental amputation neuromas. J Am Dent Assoc. 1965;70:662–75. https://doi.org/10.14219/jada.archive.1965.0253.
McKay C. Two neurogenic tumors of the oral cavity. Oral Surg Oral Med Oral Pathol. 1957;10(1):32–6. https://doi.org/10.1016/s0030-4220(57)80110-8.
Mozsary PG, Middleton RA, Szabo Z. Microsurgical treatment of traumatic neuroma of the inferior alveolar nerve. J Oral Maxillofac Surg. 1982;40(7):446–8. https://doi.org/10.1016/0278-2391(82)90084-2.
Gregg JM. Studies of traumatic neuralgias in the maxillofacial region: surgical pathology and neural mechanisms. J Oral Maxillofac Surg. 1990;48(3):228–37; discussion 38–9. https://doi.org/10.1016/0278-2391(90)90385-f.
Oringer MJ. Neuroma of the mandible. Oral Surg Oral Med Oral Pathol. 1948;1(12):1135. https://doi.org/10.1016/0030-4220(48)90036-x.
Mathews GJ, Osterholm JL. Painful traumatic neuromas. Surg Clin North Am. 1972;52(5):1313–24. https://doi.org/10.1016/s0039-6109(16)39843-7.
Lans J, Hoftiezer Y, Lozano-Calderón SA, Heng M, Valerio IL, Eberlin KR. Risk factors for neuropathic pain following major upper extremity amputation. J Reconstr Microsurg. 2021;37(5):413–20. https://doi.org/10.1055/s-0040-1718547.
Derry S, Wiffen PJ, Moore RA, Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014;2014(7):Cd010958. https://doi.org/10.1002/14651858.CD010958.pub2.
Baron R, Mayoral V, Leijon G, Binder A, Steigerwald I, Serpell M. 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study. Curr Med Res Opin. 2009;25(7):1663–76. https://doi.org/10.1185/03007990903047880.
Author information
Authors and Affiliations
Contributions
Davis C. Thomas: conceptualization, investigation, methodology, writing/reviewing/editing, analysis. Saranya Devatha Mallareddy: writing/reviewing/editing, literature search. Jeffrey P. Okeson: writing/reviewing/editing, literature search. Josna Thankachan: writing/reviewing/editing, literature search. Priyanka Kodaganallur Pitchumani: writing/reviewing/editing, literature search. Reshmy Chellam Pichammal: writing/reviewing/editing, literature search, investigation, methodology, medical illustrations.
Corresponding author
Ethics declarations
Conflict of Interest
Davis C Thomas, Saranya Devatha Mallareddy, Priyanka Kodaganallur Pitchumani, Reshmy Chellam Pichammal, Josna Thankachan, and Jeffrey P Okeson declare no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Uncommon and/or Unusual Headaches and Syndromes
Rights and permissions
About this article
Cite this article
Thomas, D.C., Mallareddy, S.D., Okeson, J.P. et al. Trigeminal Traumatic Neuroma: a Comprehensive Review of the Literature Based On a Rare Case. Curr Pain Headache Rep 26, 219–233 (2022). https://doi.org/10.1007/s11916-022-01018-w
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11916-022-01018-w