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New and Old Osteocytic Cell Lines and 3D Models

  • Osteocytes (J Delgado-Calle and J Klein-Nulend, Section Editors)
  • Published:
Current Osteoporosis Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells,

Recent Findings

Osteocytes are the main orchestrators of bone remodeling. They control both osteoblasts and osteoclast activities via cell-to cell communication or through secreted factors. Osteocytes are also the mechanosensors of the bone and they orchestrate skeletal adaptation to loads. Recent discoveries have greatly expanded our knowledge and understanding of these cells and new models are now available to further uncover the functions of osteocytes.

Summary

Novel osteocytic cell lines, primary cultures, and 3D scaffolds are now available to investigators to further unravel the functions and roles of these cells.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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  1. Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street, W201E, Boston, MA, 02118, USA

    Paola Divieti Pajevic

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Divieti Pajevic, P. New and Old Osteocytic Cell Lines and 3D Models. Curr Osteoporos Rep 18, 551–558 (2020). https://doi.org/10.1007/s11914-020-00613-3

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