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Integrins in Osteocyte Biology and Mechanotransduction

  • Osteocytes (J Klein-Nulend, Section Editor)
  • Published:
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Abstract

Purpose of Review

Osteocytes are the main mechanosensitive cells in bone. Integrin-based adhesions have been shown to facilitate mechanotransduction, and therefore play an important role in load-induced bone formation. This review outlines the role of integrins in osteocyte function (cell adhesion, signalling, and mechanotransduction) and possible role in disease.

Recent Findings

Both β1 and β3 integrins subunits have been shown to be required for osteocyte mechanotransduction. Antagonism of these integrin subunits in osteocytes resulted in impaired responses to fluid shear stress. Various disease states (osteoporosis, osteoarthritis, bone metastases) have been shown to result in altered integrin expression and function.

Summary

Osteocyte integrins are required for normal cell function, with dysregulation of integrins seen in disease. Understanding the mechanism of faulty integrins in disease may aid in the creation of novel therapeutic approaches.

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Funding

This publication has emanated from research conducted with the financial support of Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073 and Grant Number 14/IA/2884. The authors received funding from European Research Council (ERC) Starting Grants (336882 and 258992) and Science Foundation Ireland (SFI) Grants 13/ERC/L2864 and 12/RC/2278.

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  1. Department of Mechanical and Biomedical Engineering, Mechanobiology and Medical Device Research Group (MMDRG), Biomedical Engineering, National University of Ireland, Galway, Ireland

    Ivor P. Geoghegan & Laoise M. McNamara

  2. Centre for Research in Medical Devices (CÚRAM), National University of Ireland, Galway, Ireland

    Ivor P. Geoghegan, David A. Hoey & Laoise M. McNamara

  3. Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

    David A. Hoey

  4. Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland

    David A. Hoey

  5. Advanced Materials and Bioengineering Research Centre, Trinity College Dublin & RCSI, Dublin 2, Ireland

    David A. Hoey

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Geoghegan, I.P., Hoey, D.A. & McNamara, L.M. Integrins in Osteocyte Biology and Mechanotransduction. Curr Osteoporos Rep 17, 195–206 (2019). https://doi.org/10.1007/s11914-019-00520-2

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