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Ravages of Diabetes on Gastrointestinal Sensory-Motor Function: Implications for Pathophysiology and Treatment

  • Neurogastroenterology and Motility Disorders of the Gastrointestinal Tract (S Rao, Section Editor)
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Abstract

Symptoms related to functional and sensory abnormalities are frequently encountered in patients with diabetes mellitus. Most symptoms are associated with impaired gastric and intestinal function. In this review, we discuss basic concepts of sensory-motor dysfunction and how they relate to clinical findings and gastrointestinal abnormalities that are commonly seen in diabetes. In addition, we review techniques that are available for investigating the autonomic nervous system, neuroimaging and neurophysiology of sensory-motor function. Such technological advances, while not readily available in the clinical setting, may facilitate stratification and individualization of therapy in diabetic patients in the future. Unraveling the structural, mechanical, and sensory remodeling in diabetes disease is based on a multidisciplinary approach that can bridge the knowledge from a variety of scientific disciplines. The final goal is to increase the understanding of the damage to GI structures and to sensory processing of symptoms, in order to assist clinicians with developing an optimal mechanics based treatment.

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Acknowledgments

HG was supported in part by grants from the Chongqing Science and Technology Commission (cstc2013kjrc-ljrccj10003) and the National “111 Plan” Base (B06023). DL and JZ were supported by a grant from the Karen Elise Jensen foundation.

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Authors and Affiliations

  1. GIOME and the Key Laboratory for Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China

    Hans Gregersen

  2. Giome Academia, Department of Medicine, Aarhus University, Aarhus, Denmark

    Donghua Liao & Jingbo Zhao

  3. Faculty of Health Sciences, Aarhus University, Aarhus, Denmark

    Anne Mohr Drewes

  4. Mech-Sense, Department of Gastroenterology and Hepatology & Clinical Institute, Aalborg University Hospital, Aalborg, Denmark

    Asbjørn Mohr Drewes

  5. GIOME, College of Bioengineering, Chongqing University, 83 Shabei Lu, Chongqing, China

    Hans Gregersen

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  1. Hans Gregersen
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  2. Donghua Liao
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  3. Anne Mohr Drewes
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  4. Asbjørn Mohr Drewes
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Correspondence to Hans Gregersen.

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Conflict of Interest

Hans Gregersen has received a patent for a multimodal motility device that is broadly relevant to some of the work described in this article.

Donghua Liao, Anne Mohr Drewes, Asbjørn Mohr Drewes, and Jingbo Zhao declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with animal subjects performed by any of the authors. With regard to the authors’ research cited in this paper, all procedures were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000 and 2008.

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This article is part of the Topical Collection on Neurogastroenterology and Motility Disorders of the Gastrointestinal Tract

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Gregersen, H., Liao, D., Drewes, A.M. et al. Ravages of Diabetes on Gastrointestinal Sensory-Motor Function: Implications for Pathophysiology and Treatment. Curr Gastroenterol Rep 18, 6 (2016). https://doi.org/10.1007/s11894-015-0481-x

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