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A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction

  • Genetics (AP Morris, Section Editor)
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Abstract

Purpose of Review

The purpose of this review was to summarize and reflect on advances over the past decade in human genetic and metabolomic discovery with particular focus on their contributions to type 2 diabetes (T2D) risk prediction.

Recent Findings

In the past 10 years, a combination of advances in genotyping efficiency, metabolomic profiling, bioinformatics approaches, and international collaboration have moved T2D genetics and metabolomics from a state of frustration to an abundance of new knowledge.

Summary

Efforts to control and prevent T2D have failed to stop this global epidemic. New approaches are needed, and although neither genetic nor metabolomic profiling yet have a clear clinical role, the rapid pace of accumulating knowledge offers the possibility for “multi-omic” prediction to improve health.

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Funding

Research is supported by NIDDK U01 DK078616. JBM is also supported by K24 DK080140, and MSU is supported by NIDDK 1K23DK114551-01.

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Author notes

  1. Jordi Merino and Miriam S. Udler contributed equally as first authors.

Authors and Affiliations

  1. Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02115, USA

    Jordi Merino, Miriam S. Udler & Aaron Leong

  2. Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02141, USA

    Jordi Merino, Miriam S. Udler, Aaron Leong & James B. Meigs

  3. Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA

    Aaron Leong & James B. Meigs

Authors
  1. Jordi Merino
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  2. Miriam S. Udler
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  3. Aaron Leong
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  4. James B. Meigs
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Correspondence to Miriam S. Udler.

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Jordi Merino, Miriam Udler, Aaron Leong, and James Meigs declare no conflict of interest related to this manuscript.

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This article does not report any new studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Genetics

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Merino, J., Udler, M.S., Leong, A. et al. A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction. Curr Diab Rep 17, 135 (2017). https://doi.org/10.1007/s11892-017-0958-0

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