Abstract
Worldwide, colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and second in females, with an estimated 1.4 million cases and 693,900 deaths in 2012. The current screening modalities utilized in the USA are examined in this review, along with current colonoscopy quality indicators. The contribution of CRC screening to the rising cost of health care in the USA has warranted recent public interest and has overall been demonstrated to be cost-effective. In addition, numerous barriers to screening are analyzed along with models for risk stratifying CRC risk at both an individual and population level. Recently, recognized risk stratification models from the Netherlands and Asia are compared with those developed in the USA, and the applicability of each to the US population is evaluated. Ultimately, this review presents the challenges and potential solutions in moving forward in the realm of CRC screening.
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Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]. Lyon: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr.
Singh H, Nugent Z, Demers AA, Kliewer EV, Mahmud SM, Bernstein CN. The reduction in colorectal cancer mortality after colonoscopy varies by site of the cancer. Gastroenterology. 2010;139:1128–37.
Atkins WS, Edwards R, Kralj-Hans I, et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicenter randomized controlled trial. Lancet. 2010;375(9726):1624–33.
Brenner H, Hoffmeister M, Arndt V, Stegmaier C, Altenhofen L, Haug U. Protection form right- and left-sided colorectal neoplasms after colonoscopy: population-based study. J Natl Cancer Inst. 2010;102(2):89–95.
Baxter NN, Goldwasser MA, Paszat LF, Saskin R, Urbach DR, Rabeneck L. Association of colonoscopy and death from colorectal cancer. Ann Intern Med. 2009;150(1):1–8.
Auge JM, Pellise M, Escudero JM, et al. Risk stratification for advanced colorectal neoplasia according to fecal hemoglobin concentration in a colorectal cancer screening program. Gastroenterology. 2014;147:628–36.
Kahi CJ, Imperiale TF, Juliar BE, Rex DK. Effect of screening colonoscopy on colorectal cancer incidence and mortality. Clin Gastroenterol Hepatol. 2009;7(7):770–5.
Lieberman D. Progress and challenges in colorectal cancer screening and surveillance. Gastroenterology. 2010;138(6):2115–26.
Yang DX, Gross CP, Soulos PR, Yu JB. Estimating the magnitude of colorectal cancers prevented during the era of screening: 1976 to 2009. Cancer. 2014;120(18):2893–901. An evaluation of the true value of colorectal cancer screening.
Young P, Womeldorph C. Colonoscopy for colorectal cancer screening. J Cancer. 2013;4(3):217–26.
Sharaf RN, Ladabaum U. Comparative effectiveness and cost-effectiveness of screening colonoscopy vs. sigmoidoscopy and alternative strategies. Am J Gastroenterol. 2013;108:120–32.
Colorectal Cancer Facts and Figures: 2014–2016. American Cancer Society, Inc. Retrieved from: https://www.cancer.org/acs.
Levin B, Lieberman DA, McFarland B, American Cancer Society Colorectal Cancer Advisory Group; US Multi-Society Task Force; American College of Radiology Colon Cancer Committee, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology. 2008;134(5):1570–95.
Winawer SJ, Zauber AG, Nah Ho M, et al. Prevention of colorectal cancer by colonoscopy polypectomy. N Engl J Med. 1993;329(27):1977–81.
Brenner H, Chang-Claude J, Seiler CM, Sturmer T, Hoffmeister M. Potential for colorectal cancer prevention of sigmoidoscopy versus colonoscopy: population-based case control study. Cancer Epidemiol Biomarkers Prev. 2007;16(3):494–9.
Muller AD, Sonnenberg A. Protection by endoscopy against death from colorectal cancer. A case–control study among veterans. Arch Intern Med. 1995;155:1741–8.
Elmunzer BJ, Singal AG, Sussman JB, et al. Comparing the effectiveness of competing tests for reducing colorectal cancer mortality: a network meta-analysis. Gastrointest Endosc. 2015;81(3):700–9.
Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med. 2000;343:169–74.
Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. N Engl J Med. 2000;343:162–8.
Mandel JS, Church TR, Ederer F, Bond JH. Colorectal cancer mortality: effectiveness of biennial screening for fecal occult blood. J Natl Cancer Inst. 1999;91(5):434–7.
Scholefield JH, Moss SM, Mangham CM, Whynes DK, Hardcastle JD. Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up. Gut. 2012;61:1036–40. Long-term data on a groundbreaking study in the area of colorectal cancer screening.
Aniwan S, Rerknimitr R, Kongkam P, Wisedopas N, Ponuthai Y, Chaithongrat S, et al. A combination of clinical risk stratification and fecal immunochemical test results to prioritize colonoscopy screening in asymptomatic participants. Gastrointest Endosc. 2015;81(3):719–27. An example of an excellent risk stratification model to increase the cost-effectiveness of colorectal cancer screening.
Hundt S, Haug U, Brenner H. Comparative evaluation if immunohistochemical fecal occult blood tests for colorectal adenoma detection. Ann Intern Med. 2009;150:162–9.
Park DI, Ryu S, Kim YH, et al. Comparison of guaiac-based and quantitative immunohistochemical fecal occult blood testing in a population at average risk undergoing colorectal cancer screening. Am J Gastroenterol. 2010;105:2017–25.
Wong MCS, Ching JYL, Chan VCW, et al. Diagnostic accuracy of a qualitative fecal immunohistochemical test varies with location of neoplasia but not number of specimens. Clin Gastroenterol Hepatol. 2015.
Bleyer A, Welch HG. Effect of three decades of screening mammography on breast-cancer incidence. N Engl J Med. 2012;367:1998–2005.
Bjorkman D, Popp J. Measuring the quality of endoscopy. Gastrointest Endosc. 2006;63(Suppl):LS1–S2.
Faigel D, Pike I, Baron T, et al. Quality indicators for gastrointestinal endoscopic procedures: an introduction. Gastrointest Endosc. 2006;63(Suppl):S2–9.
Rex D, Schoenfeld P, Cohen J, et al. Quality indicators for colonoscopy. Am J Gastroenterol. 2015;110:72–90.
Kaminski M, Regula J, Kraszewska E, et al. Quality indicators for colonoscopy and the risk of interval cancer. N Engl J Med. 2010;362:1795–803.
Corley D, Jensen C, Mrks A, et al. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014;370:1299801306. This article highlighted the association between low ADR and poor outcomes.
Rogal S, Pinsky P, Schoen R. Relationship between detection of adenomas by flexible sigmoidoscopy and interval distal colorectal cancer. Clin Gastroenterol Hepatol. 2013;11:73–8.
Rex D, Johnson D, Anderson J, et al. American College of Gastroenterology guidelines for colorectal cancer screening 2008. Am J Gastroenterol. 2009;104:739–50.
Baxter N, Sutradhar R, Forbes S, et al. Analysis of administrative data finds endoscopist quality measures associated with post-colonoscopy colorectal cancer. Gastroenterology. 2011;140:65–72.
Hosokawa O, Shirasaki S, Kaizaki Y, et al. Invasive colorectal cancer detected up to 3 years after a colonoscopy negative for cancer. Endoscopy. 2003;35:506–10.
Leaper M, Johnston M, Barclay M, et al. Reasons for failure to diagnose colorectal carcinoma at colonoscopy. Endoscopy. 2004;36:499–503.
Lee T, Rutter M, Blanks R, et al. Colonoscopy quality measures: experience from the NHS bowel cancer screening programme. Gut. 2012;61:1050–7.
Chen S, Rex D. Variable detection of non-adenomatous polyps by individual endoscopists at colonoscopy ad correlation with adenoma detection. J Clin Gastroenterol. 2008;42:704–7.
Rex D. Colonoscopic withdrawal technique is associated with adenoma miss rates. Gastrointest Endosc. 2000;51:33–6.
Lee R, Tang R, Muthusamy V, et al. Quality of colonoscopy withdrawal technique and variability in adenoma detection rates (with videos). Gastrointest Endosc. 2011;74:128–34.
Barclay R, Vicari J, Johanson J, et al. Variation in adenoma detection rates and colonoscopic withdrawal times during screening colonoscopy {abstract}. Gastrointest Endosc. 2005;61:AB107.
Sanchez W, Harewood G, Petersen B. Evaluation of polyp detection in relation to procedure time of screening or surveillance colonoscopy. Am J Gastroenterol. 2004;99:1941–5.
Fatima H, Rex D, Rothstein R, et al. Cecal insertion and withdrawal times with wide-angle versus standard colonoscopies: a randomized controlled trial. Clin Gastroenterol Hepatol. 2008;6:109–14.
Simmons D, Haregood G, Baron T, et al. Impact of endoscopist withdrawal speed on polyp yield: implications for optimal colonoscopy withdrawal time. Aliment Pharmacol Ther. 2006;24:965–71.
Lim G, Viney S, Chapman B, et al. A prospective study of endoscopist-blinded colonoscopy withdrawal times and polyp detection rates in a tertiary hospital. N Z Med J. 2012;125:52–9.
Lin O, Kozarek R, Arai A, et al. The effect of periodic monitoring and feedback on screening colonoscopy withdrawal times, polyp detection rates, and patient satisfaction scores. Gastrointest Endosc. 2010;71:1253–9.
Johnson D, Barkun A, Coehn L, et al. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US Multi-Society Task Force on colorectal cancer. Am J Gastroenterol. 2014;109:1528–45.
Calderwood A, Jacobson B. Comprehensive validation of the Boston Bowel Preparation Scale. Gastrointest Endosc. 2010;72:686–92.
Rostom A, Jolicoeur E. Validation of a new scale for the assessment of bowel preparation quality. Gastrointest Endosc. 2004;59:482–6.
Williams J, Le T, Faigel D. Polypectomy rate as a quality measure for colonoscopy. Gastrointest Endosc. 2011;73:498–506.
Williams J, Holub J, Faigel D. Polypectomy rate is a valid quality measure for colonoscopy: results from a national endoscopy database. Gastrointest Endosc. 2012;75:576–82.
Hilsden R, Rostom A, Dube C, et al. Is polyp detection rate a valid proxy for adenoma detection rate for measuring the technical quality of colonoscopy? Gastroenterology. 2010;138:S57.
Francis D, Rodriquez-Correa D, Buchner A, et al. Application of a conversion factor to estimate the adenoma detection rate from the polyp detection rate. Gastrointest Endosc. 2011;73:493–7.
Cooper G, Xu F, Barnholtz S, et al. Prevalence and predictors of interval colorectal cancers in Medicare beneficiaries. Cancer. 2012;118:3044–52.
Bressler B, Paszat L, Chen Z, et al. Rates of new or missed colorectal cancers after colonoscopy and their risk factors: a population-based analysis. Gastroenterology. 2007;132:96–102.
Robertson D, Lieberman D, Winawer S, et al. Interval cancer after total colonoscopy: results from a pooled analysis of eight studies. Gastroenterology. 2008;134:A-111.
Pohl H, Robertson D. Colorectal cancer detected after colonoscopy frequently result from missed lesions. Clin Gastroenterol Hepatol. 2010;8:858–64.
Brenner H, Chang-Claude J, Seiler C, et al. Interval cancers after negative colonoscopy: population-based case–control study. Gut. 2012;61:1576–82.
Singh H, Nugent Z, Mahmud S, et al. Predictors of colorectal cancer after negative colonoscopy: a population-based study. Am J Gastroenterol. 2010;105:663–73.
Limketkai B, Lam-Himlin D, Arnold M, et al. The cutting edge of serrated polyps: a practical guide to approaching and managing serrated colon polyps. Gastrointest Endosc. 2013;77:360–75.
Crockett S, Snover D, Ahnen D, Baron J. Sessile serrated adenomas: an evidence-based guide to management. Clin Gastroenterol Hepatol. 2015;13:11–26.
Tinmouth J, Henry P, Hsieh E, et al. Sessile serrated polyps at screening colonoscopy: have they been under diagnosed? Am J Gastroenterol. 2014;109:1698–704.
Fayad N, Kahi C. Quality measures for colonoscopy: a critical evaluation. Clin Gastroenterol Hepatol. 2014;12:1973–80. This article highlights the strength and weaknesses of current quality indicators.
Kahi C, Hewett D, Norton D, et al. Prevalence and variable detection of proximal colon serrated polyps during screening colonoscopy. Clin Gastroenterol Hepatol. 2011;9:42–6.
Kahi C, Li X, Ecckekrt G, et al. High colonoscopic prevalence of proximal colon serrated polyps in average-risk men and women. Gastrointest Endosc. 2012;75:515–20.
Hetzel J, Huang C, Coukos J, et al. Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol. 2010;105:2656–64.
Subramanian V, Mannath J, Hawkey C, et al. High definition colonoscopy vs. standard video endoscopy for the detection of colonic polyps: A meta-analysis. Endoscopy. 2011;43:499–505.
Kahi C, Anderson J, Waxman I, et al. High-definition chromocolonoscopy vs. high-definition white light colonoscopy for average-risk colorectal cancer screening. Am J Gastroenterol. 2010;105:1301–7.
De Wijkerslooth T, Stoop E, Bossuyt P, et al. Adenoma detection with cap-assisted colonoscopy versus regular colonoscopoy: a randomized controlled trial. Gut. 2012;61:1426–34.
Dinesen L, Chua T, Kaffes A. Meta-analysis of narrow-band imaging versus conventional colonoscopy for adenoma detection. Gastrointest Endosc. 2012;75:604–11.
Leufkens A, DeMarco D, Rastogi A, et al. Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study. Gastrointest Endosc. 2011;73:480–9.
Gralnek I, Siiersema P, Halpern Z, et al. Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicenter, randomized, tandem colonoscopy trial. Lancet Oncol. 2014;15:353–60.
Gross S, Zamir H, Santo E, et al. A novel balloon-colonoscope for increased polyp/adenoma detection rate: results of a randomized tandem study. Am J Gastroenterol 108:S632–633.
Biecker E, Floer M, Heinecke A, et al. The endocuff-assisted colonoscopy significantly increases the polyp and adenoma detection: results of a prospective randomized study with 498 patients. Oral presentation at DDW 2014, Chicago, IL.
Centers for Disease Control and Prevention. Vital signs: colorectal cancer screening test use—United States, 2012. MMWR Morb Mortal Wkly Rep. 2013;62:881–8.
von Karsa L, Anttila A, Ronco G, Ponti A, Malila N, Arbyn M, et al. Cancer screening in the European Union. Report on the implementation of the Council Recommendation on cancer screening—first report. ISBN 978-92-79-08934-3. European Communities (publ.) Printed in Luxembourg by the services of the European Commission. Lyon: IARC press; 2008.
Guessous I, Dash C, Lapin P, et al. Colorectal cancer screening barriers and facilitators in older persons. Prev Med. 2010;50:3–10.
Bromley E, May F, Federer L, et al. Explaining persistent under-use of colonoscopic cancer screening in African Americans: a systematic review. Prev Med. 2015;71:40–8. A very relevant look at current barriers to screening in populations where colorectal cancer screening is underutilized.
Fidler H, Hartnett A, Cheng Man K, et al. Sex and familiarity of colonoscopists: patient preferences. Endoscopy. 2000;32:481–2.
Menees S, Inadomi J, Korsnes S, et al. Women patients’ preference for women physicians is a barrier to colon cancer screening. Gastrointest Endosc. 2005;62:219–23.
Varadarajulu S, Petruff C, Ramsey W. Patient preferences for gender of endoscopists. Gastrointest Endosc. 2002;56:170–3.
Denberg T, Kraus H, Soenksen A, et al. Rates of screening colonoscopy are not increased when women are offered a female endoscopist in a health promotion outreach program. Gastrointest Endosc. 2010;72:1014–9.
Bazargan M, Ani C, Bazargan-Hejazi S, et al. Coloreectal cancer screening among underserved minority population: discrepancy between physicians’ recommended, scheduled, and completed tests. Patient Educ Couns. 2009;76:240–7.
Carcaise-Edinboro P, Bradley C. Influence of patient-provider communication on colorectal cancer screening. Med Care. 2008;46:738–45.
Seeff L, Nadel M, Klabunde C, et al. Patterns and predictors of colorectal cancer test use in the adult U.S. population. Cancer. 2004;100:2093–103.
Laiyemo A, Adebogun A, Doubeni C, et al. Influence of provider discussion and specific recommendation on colorectal cancer screening uptake among U.S. adults. Prev Med. 2014;67:1–5.
Inadomi J, Vijan S, Janz N, et al. Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies. Arch Intern Med. 2012;172:575–82.
Kushnir VM, Oh YS, Hollander T, et al. Impact of retroflexion vs second forward view examination of the right colon on adenoma detection: a comparison study. Am J Gastroenterol. 2015;110(3):415–22. This study has the ability to strongly impact current colonoscopy techniques in order to increase the diagnostic yield of colonoscopy.
Imperiale TF, Monahan PO, Stump TE, et al. Derivation and validation of a scoring system to stratify risk for advanced colorectal neoplasia in asymptomatic adults. Ann Intern Med. 2015;163:339–46. This is an example of an excellent system that when implemented, can make current colorectal cancer screening methods more cost-effective.
Stegeman I, Wijkerslooth TR, Stoop EM, et al. Combining risk factors with faecal immunochemical test outcome for selecting CRC screenees for colonoscopy. Gut. 2014;63:466–71.
Yeoh KG, Ho KY, Chiu HM, et al. The Asia-Pacific Colorectal Screening score: a validated tool that stratifies the risk for colorectal advanced neoplasia in asymptomatic Asian subjects. Gut. 2011;60:1236–41.
Weinberg DS, Myers RE, Keenan E, Ruth K, Sifri R, Ziring B, et al. Genetic and environmental risk assessment and colorectal cancer screening in an average-risk population: a randomized trial. Ann Intern Med. 2014;161(8):527–45. This is an excellent example of an effective risk stratification model that can increase the cost effectiveness of current colorectal cancer screening modalities.
Myers RE, Ruth K, Manne SL, Cocroft J, Sifri R, Ziring B, et al. Effects of genetic and environmental risk assessment feedback on colorectal screening adherence. J Behav Med. 2015.
Baker DW, Brown T, Buchanan DR, et al. Comparative effectiveness of a multifaceted intervention to improve adherence to annual colorectal cancer screening in community health centers: a randomized clinical trial. JAMA Int Med. 2014;174(8):1235–41. This is a current and effective attempt to increase patient adherence to current colorectal cancer screening.
Anderson M. 6 facts about Americans and their smartphones. Pew Research Center: Internet, Science, and Tech; 2015.
Tarkan L. Getting a colonoscopy? There’s an app for that. Fox News Online. 2013. Retrieved from https://www.foxnews.com/health/2013/05/20/getting-colonoscopy-there-app-for-that/.
Kavathia N, Berggreen P, Gerkin R. Outcomes of smart phone application assisted bowel preparation for colonoscopy. Digestive Disease Week 2013. This is a very relevant and cutting edge implementation to capture a younger, more technologically advanced patient population in order to increase colorectal cancer screening adherence.
Heitman SJ, Hilsden RJ, Au F, Dowden S, Manns BJ. Colorectal cancer screening for average-risk North Americans: an economic evaluation. PLoS Med. 2010;7(11), e1000370.
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Induruwa N. Pathirana, Dustin M. Albert, Patrick E. Young, and Craig Womeldorph declare that they have no conflict of interest.
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Pathirana, I.N., Albert, D.M., Young, P.E. et al. Colorectal Cancer Screening: a North American Point of View. Curr Colorectal Cancer Rep 12, 241–250 (2016). https://doi.org/10.1007/s11888-016-0330-9
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DOI: https://doi.org/10.1007/s11888-016-0330-9