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Birth Weight and Risk of Cardiovascular Disease Incidence in Adulthood: a Dose-Response Meta-analysis

  • Evidence-Based Medicine, Clinical Trials and Their Interpretations (L. Roever, Section Editor)
  • Published:
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Abstract

Purpose of Review

Studies have revealed a relation between birth weight (BW) and later risk of cardiovascular diseases (CVDs). This meta-analysis aimed to report the dose-response relationship between BW and risk of CVDs.

Recent Findings

The relation of BW to CVD subtypes was found to be U-shaped as BW below ~ 2500 g and above ~ 4000 g affected positively CVD risk (OR = 1.14 = 95%CI 1.03–1.27 and OR = 1.08; 95%CI 0.99–1.18, respectively). Regarding CVD subtypes, low BW was directly linked to greater risk of CHD (OR = 1.15; 95%CI 1.02–1.29) and stroke (OR = 1.28; 95% CI 1.05–1.55), while high BW was related to increased risk of arterial fibrillation in adulthood. A U-shaped nonlinear relationship was specifically demonstrated between BW and overall CVD and its subtypes.

Summary

There is a U-shaped association between BW and all CVD subtypes.

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Authors and Affiliations

  1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Reza Mohseni

  2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences-International Campus (TUMS-IC), Tehran, Iran

    Shimels Hussien Mohammed

  3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Maryam Safabakhsh

  4. School of Medicine, Arak University of Medical Sciences, Arak, Iran

    Fatemeh Mohseni

  5. School of Nursing & Midwifery, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Zahra Sajedi Monfared

  6. Department of Medical Surgical Nursing, School of Nursing & Midwifery, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Javad Seyyedi

  7. Student Research Committee, School of Medicine, Iran University of Medical Sciences (TUMS), Tehran, Iran

    Zahra Noorani Mejareh

  8. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Shahab Alizadeh

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  1. Reza Mohseni
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Correspondence to Shahab Alizadeh.

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Reza Mohseni, Shimels Hussien Mohammed, Maryam Safabakhsh, Fatemeh Mohseni, Zahra Sajedi Monfared, Javad Seyyedi, Zahra Noorani Mejareh, and Shahab Alizadeh each declare that they have no conflict of interest.

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Mohseni, R., Mohammed, S.H., Safabakhsh, M. et al. Birth Weight and Risk of Cardiovascular Disease Incidence in Adulthood: a Dose-Response Meta-analysis. Curr Atheroscler Rep 22, 12 (2020). https://doi.org/10.1007/s11883-020-0829-z

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