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New Perspectives on the Diagnosis of Allergy to Anisakis spp.

  • Immunologic/Diagnostic Tests in Allergy (M Chapman and A Pomés, Section Editors)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To compare the prevalence of sensitization in different countries based on specific IgE values and to evaluate the use of isolated native or recombinant allergens for diagnosis.

Recent Findings

Isolated allergens help in the diagnosis of truly sensitized patients avoiding false positives due to cross-reactions. Their use is therefore highly recommended, especially when used as a combination of several relevant allergens.

Summary

The use of purified allergens allows an accurate diagnosis and this has led to three important findings: (1) in addition to the digestive route of sensitization, occupational and non-digestive exposure seems to be clinically relevant. (2) The parasite appears as an important agent for chronic urticaria. And (3) in endemic countries, the amount of highly sensitized subjects in the general population could be as high as 7%. Adequate information to asymptomatic patients on fish consumption habits would avoid new contacts with parasite allergens and decrease their specific IgE levels and consequently the appearance of acute or chronic episodes induced by the parasite.

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Acknowledgements

This work has been co-funded by the European Regional Development Fund and a grant from the Ministry of Economy, Industry, and Competitiveness (AGL2015-68248-C2-2-R, MINECO/FEDER).

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Authors and Affiliations

  1. Calle Travesía de Navaluenga 38, Majadahonda, Madrid, 28221, Spain

    Ignacio Moneo

  2. Hospital La Paz Institute for Health Research (IdiPAZ), Paseo de La Castellana 261, 28046, Madrid, Spain

    Noelia Carballeda-Sangiao

  3. Unit of Immunology, University Hospital La Paz, Paseo de La Castellana 261, 28046, Madrid, Spain

    Miguel González-Muñoz

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  1. Ignacio Moneo
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Correspondence to Miguel González-Muñoz.

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Drs. Moneo, Carballeda-Sangiao, and González-Muñoz declare no conflicts of interest relevant to this manuscript.

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This article is part of the Topical Collection on Immunologic/Diagnostic Tests in Allergy

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Moneo, I., Carballeda-Sangiao, N. & González-Muñoz, M. New Perspectives on the Diagnosis of Allergy to Anisakis spp.. Curr Allergy Asthma Rep 17, 27 (2017). https://doi.org/10.1007/s11882-017-0698-x

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