Skip to main content

Advertisement

SpringerLink
Log in

Surgical Treatment for Extramammary Paget’s Disease

  • Skin Cancer (T Ito, Section Editor)
  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion statement

Extramammary Paget’s disease (EMPD) is a rare, slow growing non-melanoma skin cancer.

Diagnosis is often significantly delayed, since clinical presentation may resemble common benign dermatoses. Treatment is characterized by high recurrence rates. This is in part due to ill-defined margins and by frequent development of satellites. Improvement of outcome needs a better preoperative planning with fluorescence diagnostics or scouting biopsies. Mohs micrographic surgery has some advantages for patients, such as reduced relapse rates and prolonged relapse-free survival. Improved identification of Paget cells in cryosections by immunostainings or alternatively the use of delayed Mohs with formalin-fixed material reduces the rate of false-negative results. Surgery remains the cornerstone of treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Paget J. On disease of the mammary areola preceding cancer of the mammary gland. St Bartholomews Hosp Rep. 1874;10:87–9.

    Google Scholar 

  2. Crocker HR. Paget’s disease affecting the scrotum and penis. Trans Pathol Soc Lond. 1888;40:187–91.

    Google Scholar 

  3. Siesling S, Elferink MA, van Dijck JA, Pierie JP, Blokx WA. Epidemiology and treatment of extramammary Paget disease in the Netherlands. Eur J Surg Oncol. 2007;33:951–5.

    Article  PubMed  CAS  Google Scholar 

  4. Funaro D, Krasny M, Lam C, Desy D, Sauthier P, Bouffard D. Extramammary Paget disease: epidemiology and association to cancer in a Quebec-based population. J Low Genit Tract Dis. 2013;17:167–74.

    Article  PubMed  Google Scholar 

  5. Lee SJ, Choe YS, Jung HD, Ahn SK, Cha YC, Cho KH, et al. A multicenter study on extramammary Paget’s disease in Korea. Int J Dermatol. 2011;50(5):508–15.

    Article  PubMed  Google Scholar 

  6. Kanitakis J. Mammary and extramammary Paget’s disease. J Eur Acad Dermatol Venereol. 2007;21:581–90.

    Article  PubMed  CAS  Google Scholar 

  7. Wagner G, Sachse MM. Extramammary Paget disease—clinical appearance, pathogenesis, management. J Dtsch Dermatol Ges. 2011;9:448–54.

    PubMed  Google Scholar 

  8. Murao K, Kubo Y, Ishigami T, Arase S. Lack of association between extramammary Paget’s disease and human papillomavirus infection. J Dermatol Sci. 2010;59:209–10.

    Article  PubMed  Google Scholar 

  9. Regauer S. Extramammary Paget’s disease—a proliferation of adnexal origin? Histopathology. 2006;48:723–9.

    Article  PubMed  CAS  Google Scholar 

  10. •• Kang Z, Xu F, Zhu Y, et al. Genetic analysis of mismatch repair genes alterations in extramammary Paget disease. Am J Surg Pathol. 2016;40:1517–25. Excellent genetic analysis of EMPD.

    Article  PubMed  Google Scholar 

  11. Banerjee S, Chatterjee M, Chand K. Extramammary Paget’s disease. Indian J Dermatol Venereol Leprol. 2005;71:417–20.

    Article  PubMed  Google Scholar 

  12. • Kang Z, Zhang Q, Zhang Q, et al. Clinical and pathological characteristics of extramammary Paget’s disease: report of 246 Chinese male patients. Int J Clin Exp Pathol. 2015;8:13233–40. Very large trial from China.

    PubMed  PubMed Central  CAS  Google Scholar 

  13. Choi YD, Cho NH, Park YS, Cho SH, Lee G, Park K. Lymphovascular and marginal invasion as useful prognostic indicators and the role of c-erbB-2 in patients with male extramammary Paget’s disease: a study of 31 patients. J Urol. 2005;174:561–5.

    Article  PubMed  Google Scholar 

  14. Chanda JJ. Extramammary Paget’s disease: prognosis and relationship to internal malignancy. J Am Acad Dermatol. 1985;13:1009–14.

    Article  PubMed  CAS  Google Scholar 

  15. Konstantinova AM, Shelekhova KV, Stewart CJ, Spagnolo DV, Kutzner H, Kacerovska D, et al. Depth and patterns of adnexal involvement in primary extramammary (anogenital) Paget disease: a study of 178 lesions from 146 patients. Am J Dermatopathol. 2016;38:802–8.

    Article  PubMed  Google Scholar 

  16. Ohara K, Fujisawa Y, Yoshino K, Kiyohara Y, Kadono T, Murata Y, et al. A proposal for a TNM staging system for extramammary Paget disease: retrospective analysis of 301 patients with invasive primary tumors. J Dermatol Sci. 2016;83:234–9.

    Article  PubMed  Google Scholar 

  17. van der Zwan JM, Siesling S, Blokx WA, Pierie JP, Capocaccia R. Invasive extramammary Paget’s disease and the risk for secondary tumours in Europe. Eur J Surg Oncol. 2012;38:214–21.

    Article  PubMed  Google Scholar 

  18. Shiomi T, Noguchi T, Nakayama H, Yoshida Y, Yamamoto O, Hayashi N, et al. Clinicopathological study of invasive extramammary Paget’s disease: subgroup comparison according to invasion depth. J Eur Acad Dermatol Venereol. 2013;27:589–92.

    Article  PubMed  CAS  Google Scholar 

  19. Hatta N, Yamada M, Hirano T, Fujimoto A, Morita R. Extramammary Paget’s disease: treatment, prognostic factors and outcome in 76 patients. Br J Dermatol. 2008;158:313–8.

    PubMed  CAS  Google Scholar 

  20. Ito Y, Igawa S, Ohishi Y, Uehara J, Yamamoto AI, Iizuka H. Prognostic indicators in 35 patients with extramammary Paget’s disease. Dermatol Surg. 2012;38:1938–44.

    Article  PubMed  CAS  Google Scholar 

  21. Alessandrini L, Clemente N, Perin T, Giorda G, Canzonieri V, Sopracordevole F. Extramammary Paget disease of the vulva: immunohistochemical analysis of neoangiogenesis and epithelial-mesenchymal transition markers expression. Diagn Pathol. 2018;13:2.

    Article  PubMed  Google Scholar 

  22. Shi G, Ye DW, Yao X, et al. Extramammary Paget’s diseases in men from the Shanghai area: its association with PSA level increase. APMIS. 2010;118:777–81.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Elbendary A, Xue R, Valdebran M, Torres KMT, Parikh K, Elattar I, et al. Diagnostic criteria in intraepithelial pagetoid neoplasms: a histopathologic study and evaluation of select features in Paget disease, Bowen disease, and melanoma in situ. Am J Dermatopathol. 2017;39:419–27.

    Article  PubMed  Google Scholar 

  24. De la Garza Bravo MM, Curry JL, Torres-Cabala CA, et al. Pigmented extramammary Paget disease of the thigh mimicking a melanocytic tumor: report of a case and review of the literature. J Cutan Pathol. 2014;41:529–35.

    Article  PubMed  Google Scholar 

  25. Karam A, Dorigo O. Treatment outcomes in a large cohort of patients with invasive extramammary Paget’s disease. Gynecol Oncol. 2012;125:346–51.

    Article  PubMed  Google Scholar 

  26. •• van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA. Paget disease of the vulva. Crit Rev Oncol Hematol. 2016;101:60–74. Excellent review on vulvar EMPD.

    Article  PubMed  Google Scholar 

  27. Jones IS, Crandon A, Sanday K. Paget’s disease of the vulva: diagnosis and follow-up key to management; a retrospective study of 50 cases from Queensland. Gynecol Oncol. 2011;122:42–4.

    Article  PubMed  Google Scholar 

  28. • Liu G, Yuan B, Wang Y, Xue F. Clinicopathologic study of vulvar Paget’s disease in China. J Low Genit Tract Dis. 2014;18:281–4. Large clinical study.

    Article  PubMed  Google Scholar 

  29. De Magnis A, Checcucci V, Catalano C, et al. Vulvar Paget disease: a large single-centre experience on clinical presentation, surgical treatment, and long-term outcomes. J Low Genit Tract Dis. 2013;17:104–10.

    Article  PubMed  Google Scholar 

  30. Chokoeva AA, Tchernev G, Castelli E, Orlando E, Verma SB, Grebe M, et al. Vulvar cancer: a review for dermatologists. Wien Med Wochenschr. 2015;165:164–77.

    Article  PubMed  Google Scholar 

  31. Wilkinson EJ, Brown HM. Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. Hum Pathol. 2002;33:549–54.

    Article  PubMed  Google Scholar 

  32. Niikura H, Yoshida H, Ito K, Takano T, Watanabe H, Aiba S, et al. Paget’s disease of the vulva: clinicopathologic study of type 1 cases treated at a single institution. Int J Gynecol Cancer. 2006;16:1212–5.

    Article  PubMed  CAS  Google Scholar 

  33. Nomura H, Matoda M, Okamoto S, Kondo E, Omatsu K, Kato K, et al. Clinicopathologic features and treatment outcomes of primary extramammary Paget disease of the vulva. J Low Genit Tract Dis. 2015;19:145–8.

    Article  PubMed  Google Scholar 

  34. Fan L, Zhu J, Tao X, Xu C. Intraepithelial extramammary Paget’s disease of the vulva: the clinicopathological characteristics, management, and outcome in a study of 18 female patients. Dermatol Surg. 2016;42:1142–6.

    Article  PubMed  CAS  Google Scholar 

  35. Roh HJ, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Paget’s disease of the vulva: evaluation of recurrence relative to symptom duration, volumetric excision of lesion, and surgical margin status. Acta Obstet Gynecol Scand. 2010;89:962–5.

    Article  PubMed  Google Scholar 

  36. Shaco-Levy R, Bean SM, Vollmer RT, Jewell E, Jones EL, Valdes CL, et al. Paget disease of the vulva: a study of 56 cases. Eur J Obstet Gynecol Reprod Biol. 2010;149:86–91.

    Article  PubMed  Google Scholar 

  37. Parashurama R, Nama V, Hutson R. Paget’s disease of the vulva: a review of 20 years’ experience. Int J Gynecol Cancer. 2017;27:791–3.

    Article  PubMed  Google Scholar 

  38. Mendivil AA, Abaid L, Epstein HD, Rettenmaier MA, Brown JV, Micha JP, et al. Paget’s disease of the vulva: a clinicopathologic institutional review. Int J Clin Oncol. 2012;17:569–74.

    Article  PubMed  Google Scholar 

  39. Sopracordevole F, Di Giuseppe J, De Piero G, Canzonieri V, Buttignol M, Giorda G, et al. Surgical treatment of Paget disease of the vulva: prognostic significance of stromal invasion and surgical margin status. J Low Genit Tract Dis. 2016;20:184–8.

    Article  PubMed  Google Scholar 

  40. Kyriazanos ID, Stamos NP, Miliadis L, Noussis G, Stoidis CN. Extra-mammary Paget’s disease of the perianal region: a review of the literature emphasizing the operative management technique. Surg Oncol. 2011;20:e61–71.

    Article  PubMed  Google Scholar 

  41. Lian P, Gu WL, Zhang Z, Cai GX, Wang MH, Xu Y, et al. Retrospective analysis of perianal Paget’s disease with underlying anorectal carcinoma. World J Gastroenterol. 2010;16:2943–8.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Perez DR, Trakarnsanga A, Shia J, Nash GM, Temple LK, Paty PB, et al. Management and outcome of perianal Paget’s disease: a 6-decade institutional experience. Dis Colon Rectum. 2014;57:747–51.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Isik O, Aytac E, Brainard J, Valente MA, Abbas MA, Gorgun E. Perianal Paget’s disease: three decades experience of a single institution. Int J Color Dis. 2016;31:29–34.

    Article  Google Scholar 

  44. Hegarty PK, Suh J, Fisher MB, Taylor J, Nguyen TH, Ivan D, et al. Penoscrotal extramammary Paget’s disease: the University of Texas M. D. Anderson Cancer Center contemporary experience. J Urol. 2011;186:97–102.

    Article  PubMed  Google Scholar 

  45. Zhang N, Gong K, Zhang X, Yang Y, Na Y. Extramammary Paget’s disease of scrotum—report of 25 cases and literature review. Urol Oncol. 2010;28:28–33.

    Article  PubMed  Google Scholar 

  46. Chen Q, Chen YB, Wang Z, Cai ZK, Peng YB, Zheng DC, et al. Penoscrotal extramammary Paget’s disease: surgical techniques and follow-up experiences with thirty patients. Asian J Androl. 2013;15:508–12.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Shu B, Shen XX, Chen P, Fang XZ, Guo YL, Kong YY. Primary invasive extramammary Paget disease on penoscrotum: a clinicopathological analysis of 41 cases. Hum Pathol. 2016;47:70–7.

    Article  PubMed  Google Scholar 

  48. Castelli E, Wollina U, Anzarone A, Morello V, Tomasino RM. Extramammary Paget disease of the axilla associated with comedo-like apocrine carcinoma in situ. Am J Dermatopathol. 2002;24:351–7.

    Article  PubMed  Google Scholar 

  49. Wang X, Wu L, Shi X, He X, Li W, Zhou H. Extramammary Paget’s disease of the oral mucosa and perioral skin. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:e157–63.

    Article  PubMed  Google Scholar 

  50. Zhang W, Wan C, Sun J. Ectopic extramammary Paget’s disease on the left hypochondrium. Eur J Dermatol. 2016;26:200–1.

    PubMed  CAS  Google Scholar 

  51. Debarbieux S, Dalle S, Depaepe L, Jeanniot PY, Poulalhon N, Thomas L. Extramammary Paget’s disease of the scalp: examination by in vivo and ex vivo reflectance confocal microscopy. Skin Res Technol. 2014;20:124–6.

    Article  PubMed  CAS  Google Scholar 

  52. Ogawa A, Yanagishita T, Mizutani K, Watanabe D. A rare case of quadruple extramammary Paget’s disease including an umbilical lesion. Dermatol Surg. 2014;40:813–4.

    PubMed  CAS  Google Scholar 

  53. •• Fukuda K, Funakoshi T. Metastatic extramammary Paget’s disease: pathogenesis and novel therapeutic approach. Front Oncol. 2018;8:38. Excellent review on metastatic EMPD and new possible treatment options.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Chang K, Li GX, Kong YY, Shen XX, Qu YY, Jia ZW, et al. Chemokine receptors CXCR4 and CXCR7 are associated with tumor aggressiveness and prognosis in extramammary Paget disease. J Cancer. 2017;8:2471–7.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Little JT, Lehman VT, Morris JM, Lehman JS, Diehn FE. Spinal metastases of extramammary Paget disease with radiologic-pathologic correlation. J Radiol Case Rep. 2016;10:1–8.

    PubMed  PubMed Central  Google Scholar 

  56. Sawada M, Kato J, Yamashita T, Yoneta A, Hida T, Horimoto K, et al. Imiquimod 5% cream as a therapeutic option for extramammary Paget’s disease. J Dermatol. 2018;45:216–9.

    Article  PubMed  CAS  Google Scholar 

  57. Murata T, Honda T, Egawa G, Kitoh A, Dainichi T, Otsuka A, et al. Three-dimensional evaluation of subclinical extension of extramammary Paget disease: visualization of the histological border and its comparison to the clinical border. Br J Dermatol. 2017;177:229–37.

    Article  PubMed  CAS  Google Scholar 

  58. Payapvipapong K, Nakakes A, Tanaka M. Lava lake structure and cloud-like structureless area: new clues for diagnosing extramammary Paget disease. J Eur Acad Dermatol Venereol. 2017;31:e459–61.

    Article  PubMed  CAS  Google Scholar 

  59. Peng X, Qian W, Hou J. 5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget’s disease. Biosci Trends. 2017;11:595–9.

    Article  PubMed  Google Scholar 

  60. • Wan M, Ma H, Zhao Y, Xie L, Chen Z. Clinical benefits of preoperative conventional fluorescence diagnosis in surgical treatment of extramammary Paget disease. Dermatol Surg. 2018;44:375–82. Interesting non-invasive procedure for improved tumor mapping.

    PubMed  CAS  Google Scholar 

  61. Yélamos O, Hibler BP, Cordova M, Hollmann TJ, Kose K, Marchetti MA, et al. Handheld reflectance confocal microscopy for the detection of recurrent extramammary Paget disease. JAMA Dermatol. 2017;153:689–93.

    Article  PubMed  PubMed Central  Google Scholar 

  62. •• Kaku-Ito Y, Ito T, Tsuji G, Nakahara T, Hagihara A, Furue M, et al. Evaluation of mapping biopsies for extramammary Paget disease: a retrospective study. J Am Acad Dermatol. 2017; https://doi.org/10.1016/j.jaad.2017.12.040. Important trial on scouting biopsies in EMPD.

  63. • Tagliaferri L, Casà C, Macchia G, et al. The role of radiotherapy in extramammary Paget disease: a systematic review. Int J Gynecol Cancer. 2018; https://doi.org/10.1097/IGC.0000000000001237. Detailed systematic review on the role of radiotherapy in EMPD.

  64. Wang HW, Lv T, Zhang LL, Lai YX, Tang L, Tang YC, et al. A prospective pilot study to evaluate combined topical photodynamic therapy and surgery for extramammary Paget’s disease. Lasers Surg Med. 2013;45:296–301.

    Article  PubMed  Google Scholar 

  65. Li Q, Gao T, Jiao B, et al. Long-term follow-up of in situ extramammary Paget’s disease in Asian skin types IV/V treated with photodynamic therapy. Acta Derm Venereol. 2010;90:159–64.

    Article  PubMed  CAS  Google Scholar 

  66. Becker-Wegerich PM, Fritsch C, Schulte KW, Megahed M, Neuse W, Goerz G, et al. Carbon dioxide laser treatment of extramammary Paget’s disease guided by photodynamic diagnosis. Br J Dermatol. 1998;138:169–72.

    Article  PubMed  CAS  Google Scholar 

  67. Weese D, Murphy J, Zimmern PE. Nd: YAG laser treatment of extramammary Paget’s disease of the penis and scrotum. J Urol (Paris). 1993;99:269–71.

    CAS  Google Scholar 

  68. Ziyao L, Deyong Y, Xiangyu C, Huafeng Z, Hafeez A, Jianbo W, et al. Clinical research of holmium laser therapy in extramammary Paget’s disease. Lasers Med Sci. 2014;29:1907–12.

    Article  PubMed  Google Scholar 

  69. Nitecki R, Davis M, Watkins JC, Wu YE, Vitonis AF, Muto MG, et al. Extramammary Paget disease of the vulva: a case series examining treatment, recurrence, and malignant transformation. Int J Gynecol Cancer. 2018;28:632–8.

    Article  PubMed  Google Scholar 

  70. Long B, Schmitt AR, Weaver AL, McGree M, Bakkum-Gamez JN, Brewer J, et al. A matter of margins: surgical and pathologic risk factors for recurrence in extramammary Paget’s disease. Gynecol Oncol. 2017;147:358–63.

    Article  PubMed  Google Scholar 

  71. Bae JM, Choi YY, Kim H, Oh BH, Roh MR, Nam KA, et al. Mohs micrographic surgery for extramammary Paget disease: a pooled analysis of individual patient data. J Am Acad Dermatol. 2013;68:632–7.

    Article  PubMed  Google Scholar 

  72. Kim SJ, Thompson AK, Zubair AS, Otley CC, Arpey CJ, Baum CL, et al. Surgical treatment and outcomes of patients with extramammary Paget disease: a cohort study. Dermatol Surg. 2017;43:708–14.

    Article  PubMed  CAS  Google Scholar 

  73. Hendi A, Brodland DG, Zitelli JA. Extramammary Paget’s disease: surgical treatment with Mohs micrographic surgery. J Am Acad Dermatol. 2004;51:767–73.

    Article  PubMed  Google Scholar 

  74. Wollina U. Extensive invasive extramammary Paget’s disease: surgical treatment. J Cutan Aesthet Surg. 2013;6:41–4.

    Article  PubMed  PubMed Central  Google Scholar 

  75. • Fujisawa Y, Yoshino K, Kiyohara Y, Kadono T, Murata Y, Uhara H, et al. The role of sentinel lymph node biopsy in the management of invasive extramammary Paget’s disease: multi-center, retrospective study of 151 patients. J Dermatol Sci. 2015;79:38–42. Multicenter trial on sentinel lymph node biopsy in invasive EMPD.

    Article  PubMed  Google Scholar 

  76. Ogata D, Kiyohara Y, Yoshikawa S, Tsuchida T. Usefulness of sentinel lymph node biopsy for prognostic prediction in extramammary Paget’s disease. Eur J Dermatol. 2016;26:254–9.

    PubMed  Google Scholar 

  77. Li B, Li L, Wang X, Xu K, Fang Z, Ding Q. Frozen section-guided wide local excision in the treatment of recurrent scrotal extramammary Paget’s disease. Dermatology. 2012;224:231–5.

    Article  PubMed  Google Scholar 

  78. Choi JH, Jue MS, Kim EJ, Joh OJ, Song KY, Park HJ. Extramammary Paget disease: minimal surgical therapy. Ann Dermatol. 2013;25:213–7.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Hata M, Koike I, Wada H, Miyagi E, Kasuya T, Kaizu H, et al. Postoperative radiation therapy for extramammary Paget’s disease. Br J Dermatol. 2015;172:1014–20.

    Article  PubMed  CAS  Google Scholar 

  80. • Padrnos L, Karlin N, Halfdanarson TR. Mayo Clinic Cancer Center experience of metastatic extramammary Paget disease 1998-2012. Rare Tumors. 2016;8:6804. Very large trial of EMPD.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Wollina U, Tilp M, Meseg A, Schönlebe J, Heinig B, Nowak A. Management of severe anogenital acne inversa (hidradenitis suppurativa). Dermatol Surg. 2012;38:110–7.

    Article  PubMed  CAS  Google Scholar 

  82. Narducci F, Samouelian V, Marchaudon V, Koenig P, Fournier C, Phalippou J, et al. Vacuum-assisted closure therapy in the management of patients undergoing vulvectomy. Eur J Obstet Gynecol Reprod Biol. 2012;161:199–201.

    Article  PubMed  Google Scholar 

  83. Xu XY, Shao N, Qiao D, Li Q, Yin CJ, Hua LX, et al. Reconstruction of defects in 11 patients with penile Paget’s diseases with split-thickness skin graft. Int Urol Nephrol. 2013;45:413–20.

    Article  PubMed  Google Scholar 

  84. Sakamoto Y, Nakajima H, Imanishi N, Kishi K. The interrupted V-Y advancement flap for the reconstruction of the vulvovaginal defect. Int J Dermatol. 2013;52:1125–8.

    Article  PubMed  Google Scholar 

  85. Chen Q, Chen YB, Wang Z, Cai ZK, Peng YB, Zheng DC, et al. Penoscrotal extramammary Paget’s disease: surgical techniques and follow-up experiences with thirty patients. Asian J Androl. 2013;15:508–12.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Carbotta G, Sallustio P, Prestera A, Laforgia R, Lobascio P, Palasciano N. Perineal Paget’s disease: a rare disorder and review of literature. Ann Med Surg (Lond). 2016;9:50–2.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Friedrichstrasse 41, 01067, Dresden, Germany

    Uwe Wollina MD

  2. Clinica Goldman and Hospital Moinhos de Vento, Porto Alegre, RS, Brazil

    Alberto Goldman MD

  3. Centrum Medyczne Bieniek, ul. Czechowicka 11, 52-016, Wrocław, Poland

    Andrzej Bieneck MD

  4. Department of Dermatology and Venereology, Ain Shams University Hospital, Cairo, Egypt

    Mohamed Badawy Abdel-Naser MD

  5. General and Visceral Surgery, Asklepios Klinik Altona, Paul-Ehrlich-Straße 1, 22673, Hamburg, Germany

    Sven Petersen MD

Authors
  1. Uwe Wollina MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alberto Goldman MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andrzej Bieneck MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mohamed Badawy Abdel-Naser MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sven Petersen MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Uwe Wollina MD.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Skin Cancer

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wollina, U., Goldman, A., Bieneck, A. et al. Surgical Treatment for Extramammary Paget’s Disease. Curr. Treat. Options in Oncol. 19, 27 (2018). https://doi.org/10.1007/s11864-018-0545-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11864-018-0545-x

Keywords

Search

Navigation