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Surgical Treatment of Cutaneous Extramammary Paget’s Disease

  • Medical Surgery (M Alam, Section Editor)
  • Published:
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Abstract

Extramammary Paget’s disease (EMPD) is a rare and difficult-to-treat skin cancer found in apocrine-rich body regions including the genital, perianal, and axillary skin. Wide local excision (WLE), which has been the standard of care, demonstrates high rates of local recurrence due to the tendency of EMPD to exhibit wide subclinical spread. Mohs micrographic surgery (MMS) has been shown to have lower local recurrence rates compared with WLE but higher than for more common forms of skin cancer. Techniques to preoperatively delineate clinical tumor margins or improve the accuracy of histopathological tumor identification have been reported and show promise to reduce local recurrence rates. The combination of surgical and non-surgical therapeutic options has also been encouraging, although data is limited. The development of an optimized surgical treatment strategy could improve surgical outcomes by reducing local recurrence rates and patient morbidity.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Division of Dermatologic Surgery, Hospital of the University of Pennsylvania, 3400 Civic Center Boulevard, Suite 1-330S, Philadelphia, PA, 19104, USA

    Ali Alexander Damavandy

  2. Department of Dermatology, Georgetown University Hospital, 5454 Wisconsin Avenue, Suite 725, Chevy Chase, MD, 20815, USA

    Ali Hendi

  3. Zitelli and Brodland Skin Cancer Center, Shadyside Medical Building, 5200 Centre Avenue, Suite 303, Pittsburgh, PA, 15232, USA

    John A. Zitelli

Authors
  1. Ali Alexander Damavandy
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  2. Ali Hendi
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  3. John A. Zitelli
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Correspondence to Ali Alexander Damavandy.

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Conflict of Interest

Dr. Ali Alexander Damavandy, Dr. Ali Hendi, and Dr. John A. Zitelli declare that they have no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Medical Surgery

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Damavandy, A.A., Hendi, A. & Zitelli, J.A. Surgical Treatment of Cutaneous Extramammary Paget’s Disease. Curr Derm Rep 5, 166–171 (2016). https://doi.org/10.1007/s13671-016-0142-9

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  • DOI: https://doi.org/10.1007/s13671-016-0142-9

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