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Evaluation of the ischemia modified albumin levels in familial Mediterranean fever patients

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Abstract

Background

Familial Mediterranean fever (FMF) is an autoimmune disease with periodic fever attacks recurring with mutations in the MEFV gene and chronic inflammation. The new molecule which is formed as a result of the chemical changes made by oxidative free radicals in the albumin molecule during ischemic events is called ischemia modified albumin (IMA).

Aim

The aim of this study is to evaluate the IMA levels as a predictor of the cardiovascular risk factor in FMF patients in the attack-free period and to evaluate the relationship between IMA and inflammation markers.

Methods

Forty FMF patients without any additional disease, non-smokers, and in their attacks-free period, 40 ankylosing spondylitis patients whose disease activity criteria is less than 4 from Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and 39 healthy adults were included in the cross-sectional analytical research.

Results

The value of IMA was statistically significantly higher in the AS group compared to the control group (p = 0.01). The positive correlations between IMA and ESR, LDL, total cholesterol, triglyceride, CRP, and fibrinogen were statistically significantly determined in FMF patients (respectively; r = 0.594; p < 0.001, r = 0.382; p = 0.015, r = 0.335; p = 0.034, r = 0.363; p = 0.021, r = 0.597; p < 0.001, r = 0.656; p < 0.001). The positive correlations between IMA and ESR, CRP were found in AS patients (respectively; r = 0.383; p = 0.015, r = 0.382; p = 0.015).

Conclusion

IMA can be used as a predictor similar to cardiovascular risk factors and it is a precious marker for inflammation. The use of IMA in these fields and the multi-centred and comparative studies about predictability of it may contribute to science.

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Authors and Affiliations

  1. Department of Internal Medicine, Tepecik Training and Research Hospital, Izmir, Turkey

    Yusuf Atabay, Zeynep Altın & Harun Akar

  2. Department of Medical Biochemistry, Tepecik Training and Research Hospital, Izmir, Turkey

    Ayfer Çolak

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  1. Yusuf Atabay
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  2. Zeynep Altın
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  3. Ayfer Çolak
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  4. Harun Akar
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Correspondence to Zeynep Altın.

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Atabay, Y., Altın, Z., Çolak, A. et al. Evaluation of the ischemia modified albumin levels in familial Mediterranean fever patients. Ir J Med Sci 192, 1183–1188 (2023). https://doi.org/10.1007/s11845-022-03138-z

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  • DOI: https://doi.org/10.1007/s11845-022-03138-z

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