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Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index

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Abstract

The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (r = 0.326, P = 0.002), NOx (r = −0.249, P = 0.021), urinary albumin (r = 0.270, P = 0.008), and IMA (r = 0.286, P = 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.

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Acknowledgments

E. Tatsch is a recipient of the CAPES Doctorate degree fellowship. G. V. Bochi is a recipient of the CAPES Master degree fellowship. R. N. Moresco, M. B. Moretto, and I. B. M. da Cruz are recipients of the CNPq research fellowship.

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Authors and Affiliations

  1. Laboratório de Pesquisa em Bioquímica Clínica, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Avenida Roraima 1000, Prédio 26, Sala 1401, 97105-900, Santa Maria, Rio Grande do Sul, Brazil

    Sílvia Juliane Piva, Etiane Tatsch, José Antonio Mainardi De Carvalho, Guilherme Vargas Bochi, Helena Kober, Thiago Duarte & Rafael Noal Moresco

  2. Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil

    Sílvia Juliane Piva, Etiane Tatsch, José Antonio Mainardi De Carvalho, Maria Beatriz Moretto & Rafael Noal Moresco

  3. Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil

    Guilherme Vargas Bochi, Helena Kober, Ivana Beatrice Mânica da Cruz, Maria Beatriz Moretto & Rafael Noal Moresco

  4. Departamento de Ciências da Saúde, Universidade Luterana do Brasil, Santa Maria, Rio Grande do Sul, Brazil

    Marta Maria Medeiros Frescura Duarte

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  1. Sílvia Juliane Piva
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  10. Rafael Noal Moresco
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Correspondence to Rafael Noal Moresco.

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Piva, S.J., Tatsch, E., De Carvalho, J.A.M. et al. Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index. Inflammation 36, 226–231 (2013). https://doi.org/10.1007/s10753-012-9538-2

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  • DOI: https://doi.org/10.1007/s10753-012-9538-2

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