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Continuous infusion of recombinant activated factor VII for bleeding control after lobectomy in a patient with inherited factor VII deficiency

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Abstract

Inherited factor VII (FVII) deficiency is a rare recessive inherited coagulation disorder with limited available information, especially in patients undergoing major thoracic surgery. In addition, an optimal management strategy for the disease has not been defined. We herein report a case involving a 61-year-old man with asymptomatic FVII deficiency who underwent a right middle and lower lobectomy to treat lung cancer. To the best of our knowledge, the present report is the first to describe the use of recombinant activated FVII continuous infusion for bleeding control after a major thoracic surgery in a patient with inherited FVII deficiency.

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References

  1. Mannucci PM, Duga S, Peyvandi F. Recessively inherited coagulation disorders. Blood. 2004;104:1243–52.

    Article  CAS  PubMed  Google Scholar 

  2. Mariani G, Bernardi F. Factor VII deficiency. Semin Thromb Hemost. 2009;35:400–6.

    Article  PubMed  Google Scholar 

  3. Ingerslev J, Kristensen HL. Clinical picture and treatment strategies in factor VII deficiency. Hemophilia. 1998;4:689–96.

    Article  CAS  Google Scholar 

  4. Mariani G, Herrmann FH, Dolce A, Batorova A, Etro D, Peyvandi F, et al. Clinical phenotypes and factor VII genotype in congenital factor VII deficiency. Thromb Haemost. 2005;93:481–7.

    CAS  PubMed  Google Scholar 

  5. Giansily-Blaizot M, Biron-Andreani C, Aguilar-Martinez P, de Moeloose P, Briquel ME, Goudemand J, et al. Inherited factor VII deficiency and surgery: clinical data are the best criteria to predict the risk of bleeding. Br J Haematol. 2002;117:172–5.

    Article  PubMed  Google Scholar 

  6. Benlakhal F, Mura T, Schved JF, Giansily-Blaizot M. A retrospective analysis of 157 surgical procedures performed without replacement therapy in 83 unrelated factor VII-deficient patients. J Thromb Haemost. 2011;9:1149–56.

    Article  CAS  PubMed  Google Scholar 

  7. Livnat T, Shenkman B, Spectre G, Tamarin I, Dardik R, Israeli A, et al. Recombinant factor VIIa treatment for asymptomatic factor VII deficient patients going through major surgery. Blood Coagul Fibrinolysis. 2012;23:379–87.

    Article  CAS  PubMed  Google Scholar 

  8. Humphries S, Temple A, Lane A, Green F, Cooper J, Miller G. Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (−323) insertion than the glutamine 353 variant. Thromb Haemost. 1996;75:567–72.

    CAS  PubMed  Google Scholar 

  9. Takamiya O. Genetic polymorphism (Arg353 → Gln) in coagulation factor VII gene and factor VII levels (coagulant activity, antigen and binding ability to tissue factor) in 101 healthy Japanese. Scand J Clin Lab Invest. 1995;55:211–5.

    Article  CAS  PubMed  Google Scholar 

  10. Mariani G, Dolce A, Batorova A, Auerswald G, Schved JF, Siragusa S, et al. Recombinant, activated factor VII for surgery in factor VII deficiency: a prospective evaluation—the surgical STER. Br J Haematol. 2010;152:340–6.

    Article  PubMed  Google Scholar 

  11. Mariani G, Napolitano M, Dolce A, Pérez Garrido R, Batorova A, Karimi M, et al. Replacement therapy for bleeding episodes in factor VII deficiency: a prospective evaluation. Thromb Haemost. 2013;109(2):238–47.

    Article  CAS  PubMed  Google Scholar 

  12. Schulman S, Tjonnfjord GE, Wallensten R, Martinowitz U, Kenet G. Continuous infusion of recombinant factor VII a for surgery in patients with deficiency of factor VII. Thromb Haemost. 2005;94:1177–80.

    CAS  PubMed  Google Scholar 

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Conflict of interest

None declared.

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Authors and Affiliations

  1. Division of Thoracic Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Sunto-gun, Shizuoka, 411-8777, Japan

    Naoko Miyata, Mitsuhiro Isaka, Hideaki Kojima, Tomohiro Maniwa, Shoji Takahashi & Yasuhisa Ohde

  2. Department of Bioscience, Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-Cho, Nagahama, Shiga, 526-0829, Japan

    Osamu Takamiya

Authors
  1. Naoko Miyata
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  2. Mitsuhiro Isaka
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  3. Hideaki Kojima
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  4. Tomohiro Maniwa
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  5. Shoji Takahashi
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  6. Osamu Takamiya
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  7. Yasuhisa Ohde
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Correspondence to Naoko Miyata.

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Miyata, N., Isaka, M., Kojima, H. et al. Continuous infusion of recombinant activated factor VII for bleeding control after lobectomy in a patient with inherited factor VII deficiency. Gen Thorac Cardiovasc Surg 64, 177–180 (2016). https://doi.org/10.1007/s11748-014-0455-1

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  • DOI: https://doi.org/10.1007/s11748-014-0455-1

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