Skip to main content
SpringerLink
Log in

Efficacy observation of Zhi Shen Tiao Sui acupuncture method for depression after ischemic stroke

“治神调髓”针刺法治疗缺血性脑卒中后抑郁疗效观察

  • Special Topic Study
  • Published:
Journal of Acupuncture and Tuina Science Aims and scope Submit manuscript

Abstract

Objective

To observe the clinical efficacy of Zhi Shen Tiao Sui (regulating the mind and marrow) needling in treating depression after ischemic stroke.

Methods

A total of 145 patients with depression after ischemic stroke were recruited between January 2016 and January 2018 and divided into two groups using random number table method, with 72 cases in the control group and 73 cases in the observation group. The control group received conventional treatment for ischemic stroke and medication, while the observation group was given additional Zhi Shen Tiao Sui acupuncture. The two groups were treated for 4 successive weeks. Clinical efficacy was analyzed after treatment. The neurological function pertinent scores [Hamilton depression scale (HAMD), clinical neurological deficit score (CNDS), activities of daily living (ADL), Fugl-Meyer assessment scale (FMA) and Barthel index (BI) scores], as well as the levels of cortisol (CORT) and adrenocorticotropic hormone (ACTH) were recorded in the two groups. Adverse reactions that occurred during treatment were also observed.

Results

The clinical total effective rate was 82.2% in the observation group, significantly higher than 66.7% in the control group (P<0.05). After treatment, the HAMD and CNDS scores were markedly reduced in both groups (all P<0.05), and the ADL, FMA and BI scores were markedly increased (all P<0.05). The HAMD and CNDS scores were significantly lower in the observation group than in the control group after treatment (both P<0.05), and the ADL, FMA and BI scores were significantly higher in the observation group than in the control group (all P<0.05). The levels of CORT and ACTH declined significantly after treatment in the two groups (all P<0.05), and were markedly lower in the observation group than in the control group (both P<0.05). The adverse reaction rate was 2.7% in the observation group, versus 4.2% in the control group, and the between-group difference was statistically insignificant (P>0.05).

Conclusion

Compared with sole use of Western medication, medication combined with Zhi Shen Tiao Sui acupuncture can promote the recovery of neurological function, down-regulate the levels of CORT and ACTH and enhance the clinical efficacy in treating patients with depression after ischemic stroke, with a relatively high safety rating.

【摘要】

目的: 观察“治神调髓”针刺法治疗缺血性脑卒中后抑郁的临床疗效。 方法: 纳入2016年1月至2018年1月的145例缺血性脑卒中后抑郁患者, 按照随机数字表法分为2组, 其中对照组72例, 观察组73例。对照组接受常规缺血性脑卒中治疗加药物治疗, 观察组在对照组干预基础上加用“治神调髓”针刺治疗。两组均连续治疗4周。治疗后分析两组临床疗效。治疗前后比较两组神经功能相关评分[汉密顿抑郁量表(HAMD)、临床神经功能缺损量表(CNDS)、日常生活活动(ADL)、Fugl-Meyer量表(FMA)及巴氏指数(BI)评分], 肾上腺皮质醇(CORT)和促肾上腺皮质激素(ACTH)水平, 并观察治疗期间不良反应发生情况。结果: 观察组临床总有效率为82.2%, 显著高于对照组的66.7%(P<0.05)。两组治疗后HAMD及CNDS评分均较治疗前显著降低(均P<0.05), ADL、FMA及BI评分均较治疗前显著升高(均P<0.05); 观察组治疗后HAMD及CNDS评分显著低于对照组(均P<0.05), ADL、FMA及BI评分显著高于对照组(均P<0.05)。两组治疗后CORT及ACTH水平均较治疗前显著降低(均P<0.05), 观察组治疗后CORT及ACTH水平显著低于对照组(均P<0.05)。观察组不良反应发生率为2.7%, 对照组为4.2%, 两组不良反应发生率差异无统计学意义(P>0.05)。结论: 相比于单独西药治疗,药物加“治神调髓”针刺治疗可促进缺血性脑卒中后抑郁患者神经功能恢复, 降低CORT和ACTH水平, 提高临床疗效,有较高安全性。

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Babkair LA. Risk factors for poststroke depression: an integrative review. J Neurosci Nurs, 2017, 49(2): 73–84.

    Article  Google Scholar 

  2. Zhang JP, Fan WT, Shi SH. Effect on Xingnao Jieyu decoction in post-stroke depression rats. Xinjiang Yike Daxue Xuebao, 2017, 40(12): 1598–1605.

    Google Scholar 

  3. Zhang DR, Peng X, Zhi Y. Observation on the curative effect of acupuncture combined with medicine in treating post-stroke depression. J Acupunct Tuina Sci, 2019, 17(1): 31–36.

    Article  CAS  Google Scholar 

  4. Guo B, Yue ZH, Xie ZQ, Xie LN, Wang PH, Chen LL, Zhu XS. Study on acupuncture regulating the receptors of nerve excitatory-inhibitory factor in nigral striatum of rats with spasticity of cerebral apoplexy. Zhonghua Zhongyiyao Zazhi, 2019, 34(7): 3201–3203.

    Google Scholar 

  5. Dolkun R, Li YK, Guo H, Liu ZY. Zhishen Tiaosui acupuncture on the unilateral spatial neglect after stroke: a randomized controlled trial. Zhongguo Zhen Jiu, 2019, 39(10): 1041–1045.

    PubMed  Google Scholar 

  6. Huo XC, Gao F. Chinese guideline for endovascular treatment of acute ischemic stroke 2018. Zhongguo Cuzhong Zazhi, 2018, 13(7): 706–729.

    Google Scholar 

  7. Tang L, Gao Y, Zhou L. Study on correlation between syndrome factors and biological indicators in acute stage of ischemic stroke by logistic regression model. Zhongxiyi Jiehe Xinnaoxueguanbing Zazhi, 2019, 17(17): 2584–2587.

    Google Scholar 

  8. Liu L, Huang HB, Lü GY. Diagnosis and differential diagnosis of depression. Zhongguo Linchuang Yisheng Zazhi, 2019, 47(10): 1150–1153.

    Google Scholar 

  9. Guo RJ, Yu M, Wang JL, Han AQ, Lu M, Zhang YL, Chen JX, Xing J. Establishing a TCM pattern element identification scale for depression. Beijing Zhongyiyao Daxue Xuebao, 2015, 38(8): 561–565.

    Google Scholar 

  10. Timmerby N, Andersen JH, Sondergaard S, Ostergaard SD, Bech P. A systematic review of the clinimetric properties of the 6-item version of the Hamilton depression rating scale (HAM-D6). Psychother Psychosom, 2017, 86(3): 141–149.

    Article  CAS  Google Scholar 

  11. Ji M, Li S, Dong Q, Hu W. Impact of early high-protein diet on neurofunctional recovery in rats with ischemic stroke. Med Sci Monit, 2018, 24(4): 2235–2243.

    Article  CAS  Google Scholar 

  12. Furlanis G, Ajčević M, Stragapede L, Lugnan C, Ridolfi M, Caruso P, Naccarato M, Ukmar M, Manganotti P. Ischemic volume and neurological deficit: correlation of computed tomography perfusion with the national institutes of health stroke scale score in acute ischemic stroke. J Stroke Cerebrovasc Dis, 2018, 27(8): 2200–2207.

    Article  Google Scholar 

  13. Zheng HW, Wang LJ, Zhang YL, Liu HM, Liu GW, Deng QE, Yang EM, Zhao D. Clinical observation of EEG biofeedback combined with sertraline in treating depressive disorder. Xinjiang Yike Daxue Xuebao, 2018, 41(8): 979–982.

    Google Scholar 

  14. Wichowicz HM, Gąsecki D, Landowski J, Lass P, Świerkocka M, Wiśniewski G, Nyka WN, Wilkowska A. Clinical utility of chosen factors in predicting post-stroke depression: a one-year follow-up. Psychiatr Pol, 2015, 49(4): 683–693.

    Article  Google Scholar 

  15. Li Y, Zheng H, Gao R, Yue L, Luo DN, Li Y. Effects of electroacupuncture at Back-Shu and Front-Mu points on expression of BDNF in hippocampal and intestinal tissue of intestinal hypermotility rats. Zhonghua Zhongyiyao Xuekan, 2018, 36(9): 2143–2145.

    Google Scholar 

  16. Luo XZ, Jin XQ, Wen XP, Luo L, Tang CZ. Effect of acupuncture at Taichong and Taixi on pathological morphology of hypothalamus in spontaneously hypertensive rats. Zhonghua Zhongyiyao Xuekan, 2019, 37(4): 781–787.

    Google Scholar 

  17. Jiao DY, Deng HP, Gu HY, Wang L, Zhang RC. Research of acupuncture on early interfering stroke and preventing post-stroke depression. Zhongguo Zhongyi Jichu Yixue Zazhi, 2017, 23(11): 1605–1621.

    Google Scholar 

  18. Lu XM, Ma TM. Literature study of acupoint selection rules in acupuncture-moxibustion treatment of post-stroke depression. Zhongguo Yiyao Zhinan, 2019, 17(16): 175–176.

    Google Scholar 

  19. Zhang HJ, Wang YJ, Xu TS. Effects of electroacupuncture at Baihui (GV 20) and Zusanli (ST 36) on the behaviors in post-stroke depressive mice. Zhonghua Zhongyiyao Zazhi, 2018, 33(1): 340–342.

    Google Scholar 

  20. Poretti MB, Sawant RS, Rask-Andersen M, de Cuneo MF, Schiöth HB, Perez MF, Carlini VP. Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression. Psychopharmacology, 2015, 233(6): 1077–1086.

    Article  Google Scholar 

  21. Song XJ. Comparative Study of the Effects of Acupuncture at Different Acupoint Groups on Behaviors and HPA Axis-related Hormones in Rat Models of Depression. Beijing: Master Thesis of Beijing University of Chinese Medicine, 2016.

    Google Scholar 

  22. Wu YF. Clinical Observation on Pei Yuan Jie Yu Acupuncture Treatment and the Influence of ACTH and Cort in the Blood of Post-stroke Depression. Fuzhou: Master Thesis of Fujian University of Traditional Chinese Medicine, 2017.

    Google Scholar 

  23. Deng R, Pi M, Yang ZX, Lin WS, Yu HB. Effect of electroacupuncture at Conception Vessel and Governor Vessel on correlative signals of stress-injury-repair in cerebral ischemia reperfusion rats. Shijie Zhenjiu Zazhi, 2016, 26(3): 22–30.

    Google Scholar 

  24. Meng HB. Clinical effect of Zhuyu Kaiyu Huatan decoction in treatment of post-stroke depression and its effect on neuroloqical function and monoamine neurotransmitters. Hunan Zhongyi Zazhi, 2019, 35(4): 1–3, 8.

    Google Scholar 

  25. Nie RR, Mo BW, Zeng WX, Pan HH, Li XZ, Jiang W, Qi L. Effects of acupuncture and moxibustion on serum 5-HT, NE and BDNF in patients with post-stroke depression. Xibu Yixue, 2017, 29(6): 808–812, 816.

    Google Scholar 

Download references

Acknowledgments

This work was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (新疆维吾尔自治区自然科学基金, No. 2018D01C163); National Natural Science Foundation of China (国家自然科学基金, No. 82060894).

Author information

Authors and Affiliations

  1. Xinjiang Medical University Institute of Traditional Chinese Medicine, Urumchi, 830011, China

    Zhi Yong  (智勇), Huo Xin-hui  (霍新慧) & Li Pan  (李盼)

Authors
  1. Zhi Yong  (智勇)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Huo Xin-hui  (霍新慧)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li Pan  (李盼)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhi Yong  (智勇).

Additional information

Author: Zhi Yong, M.M., lecturer, attending physician.

Conflict of Interest

The authors declare that there is no potential conflict of interest in this article.

Statement of Informed Consent

This study had been approved by the Medical Ethics Committee of Hospital of Traditional Chinese Medicine of Xinjiang Uygur Autonomous Region (Approval No. 2016XE0106-8). Informed consent was obtained from all individual participants.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yong, Z., Xin-hui, H. & Pan, L. Efficacy observation of Zhi Shen Tiao Sui acupuncture method for depression after ischemic stroke. J. Acupunct. Tuina. Sci. 19, 180–186 (2021). https://doi.org/10.1007/s11726-021-1244-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11726-021-1244-x

Keywords

【关键词】

【中图分类号】

【文献标志码】

Search

Navigation