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Efficacy observation on Governor Vessel-regulating and brain-unblocking acupuncture for post-stroke depression

调督通脑针刺法治疗中风后抑郁疗效观察

  • Clinical Study
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Abstract

Objective

To observe the clinical effect of Governor Vessel-regulating and brain-unblocking acupuncture on post-stroke depression.

Methods

A total of 70 eligible cases were randomly allocated into an observation group and a control group according to the random number table. Patients in the observation group were treated with Governor Vessel-regulating and brain-unblocking acupuncture, whereas patients in the control group were treated with oral Escitalopram Oxalate tablet. The treatment lasted for 8 weeks. The Hamilton depression scale (HAMD), Montgomery Asberg depression rating scale (MADRS), and Barthel Index (BI) were used to evaluate the patients’ condition before, 4 weeks and 8 weeks after treatment respectively. In addition, adverse reactions were also recorded.

Results

After 4 weeks of treatment, the HAMD and MADRS scores were significantly decreased in both groups (P<0.05); and the BI scores were significantly increased in both groups (P<0.05). There was no between-group statistical difference in HAMD score (P>0.05); the MADRS score in the observation group was significantly lower than that in the control group (P<0.05) and the BI score in the observation group was significantly higher than that in the control group (P<0.05). After 8 weeks of treatment, there were no between-group statistical differences in all aspects (P>0.05); however, the adverse reactions in the observation group were significantly less than those in the control group.

Conclusion

The Governor Vessel-regulating and brain-unblocking acupuncture is safe and effective for post-stroke depression and can obtain similar efficacy as Escitalopram Oxalate tablet. In addition, it can fast alleviate core symptoms of depression and improve the activities of daily living (ADL) and has fewer adverse reactions.

摘要

目的

观察调督通脑针刺法治疗中风后抑郁的临床疗效。

方法

共纳入70 例中风后抑郁患者, 采用随机数字表法随机分为观察组和对照组。观察组患者接受调督通脑针刺法治疗, 对照组患者口服草酸艾司西酞普兰片(Escitalopram Oxalate tablet)治疗, 共治疗8 星期。分别在治疗前、治疗4 星期及8 星期后进行汉密尔顿抑郁量表(Hamilton depression scale, HAMD)、蒙哥马利抑郁评定量表(Montgomery Asberg depression rating scale, MADRS)、Barthel 指数(Barthel Index, BI)评价, 同时统计不良反应。

结果

治疗4 星期后, 两组HAMD 及MADRS 评分均较本组治疗前显著降低(P<0.05), BI 评分较治疗前明显提高(P<0.05); 组间比较, 两组HAMD 评分没有统计学差异(P>0.05), 观察组MADRS 评分明显低于对照组(P<0.05), 观察组BI 评分明显高于对照组(P<0.05)。治疗8 星期后, 两组各项评分均无统计学差异(P>0.05), 但观察组不良反应发生情况明显低于对照组。

结论

调督通脑针刺法治疗中风后抑郁安全有效, 与艾斯西酞普兰总体疗效相当, 但能较快改善抑郁核心症状及日常生活活动(activities of daily living, ADL)能力, 且不良反应少。

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References

  1. Minnerup J, Schäbitz WR. Improving outcome after stroke time to treat new targets. Stroke, 2012, 43(2): 295–296.

    Article  PubMed  Google Scholar 

  2. Chinese Neuroscience Society, Chinese Neurosurgical Society. Key diagnostic points for cerebrovascular diseases. Zhonghua Shenjingke Zazhi, 1996, 29(6): 379–380.

    Google Scholar 

  3. Chinese Society of Psychiatry. Chinese Classification and Diagnostic Criteria of Mental Disorders. 3rd Edition. Jinan: Shandong Science & Technology Press, 2001: 87–88.

    Google Scholar 

  4. Nair A, Vaidya VA. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood? J Biosci, 2006, 31(3): 423–434.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry, 1979, 134: 382–389.

    Article  CAS  PubMed  Google Scholar 

  6. Yu DS, Yun XP. Physical Therapy and Occupational Therapy. Beijing: Huaxia Publishing House, 2002: 183.

    Google Scholar 

  7. Liu JL, Du YH, Li B, Xiong J, Hu YC. Quality evaluation on randomized controlled trials of acupuncture and moxibustion for post-stroke depression. Shanghai Zhenjiu Zazhi, 2010, 29(5): 327–329.

    Google Scholar 

  8. Luo RH, Xu K, Huang YS. Clinical observations on acupuncture treatment for depression. Shanghai Zhenjiu Zazhi, 2009, 28(2): 69–71.

    Google Scholar 

  9. Wang YJ, Cui LH, Yuan J, He L, Xie ZQ, Xue WH, Li M, Zhang ZW, Gao YC, Kang SB. Gao Yuchun’s experience of facial paralysis treatment. Zhongguo Zhen Jiu, 2015, 35(5): 479–482.

    PubMed  Google Scholar 

  10. Zhang LH, Zhang S, Li YH, Wang YJ, Zhang YC. Therapeutic efficacy observation on needling Yangming method for facial palsy. J Acupunct Tuina Sci, 2015, 13(6): 339–343.

    Article  Google Scholar 

  11. Yuan J, Li M, Wang YM, Gao YC. Talk about the experience on needle withdrawal techniques. Zhongguo Zhen Jiu, 2003, 23(6): 374.

    Google Scholar 

  12. Robinson RG, Kubos KL, Starr LB, Rao K, Price TR. Mood disorders in stroke patients: importance of location of lesion. Brain 1984, 107(pt 1): 81–93.

    Article  PubMed  Google Scholar 

  13. Hu L, Liang J, Jin SY, Han YJ, Lu J, Tu Y. Progress of researches on mechanisms of acupuncture underlying improvement of depression in the past five years. Zhen Ci Yan Jiu, 2013, 38(3): 253–258.

    CAS  PubMed  Google Scholar 

  14. Stux G, Pomeranz B. Acupuncture: Textbook and Atlas. Berlin: Springer-Verlag, 1987: 57.

    Book  Google Scholar 

  15. Xia JH, Xu CE, Xia WG, Zheng CJ. Clinical observation of acupuncture plus rehabilitation training for post-stroke depression. Shanghai Zhenjiu Zazhi, 2015, 34(8): 724–728.

    Google Scholar 

  16. Xu SF, Zhuang LX, Tang CZ, Yang JJ. Effects of acupuncture and embedding thread on central monoamine neurotransmitters in the depression model rat. Zhongguo Zhen Jiu, 2007, 27(6): 435–437.

    PubMed  Google Scholar 

  17. Liu HJ, He XF, Chen XH. Effects of acupuncture on praxiology and hippocampal amino-neurotransmitter in rats treated with chronic stress. Yixue Yanjiu Zazhi, 2010, 39(3): 79–81.

    Google Scholar 

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Authors and Affiliations

  1. Cangzhou Hospital of Integrated Traditional and Western Medicine, Hebei Province, Cangzhou, 061000, China

    Li-hua Zhang  (张丽华)

  2. Cangzhou Central Hospital, Hebei Province, Cangzhou, 061000, China

    Yan-chun Zhang  (张艳春)

  3. Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, 050011, China

    Yan-jun Wang  (王艳君)

  4. Graduate School of Hebei Medical University, Shijiazhuang, 050011, China

    Yi-xu Han  (韩一栩) & Peng-peng Li  (李朋朋)

Authors
  1. Li-hua Zhang  (张丽华)
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  2. Yan-chun Zhang  (张艳春)
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  3. Yan-jun Wang  (王艳君)
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  4. Yi-xu Han  (韩一栩)
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  5. Peng-peng Li  (李朋朋)
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Correspondence to Yan-jun Wang  (王艳君).

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Zhang, Lh., Zhang, Yc., Wang, Yj. et al. Efficacy observation on Governor Vessel-regulating and brain-unblocking acupuncture for post-stroke depression. J. Acupunct. Tuina. Sci. 14, 175–180 (2016). https://doi.org/10.1007/s11726-016-0920-8

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  • DOI: https://doi.org/10.1007/s11726-016-0920-8

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