Abstract
In this work, a simple and green method for the convenient synthetic protocol of 2-substituted-1H-4-carboxamide benzimidazole was reported from 2,3-diaminobenzamide and a variety of aldehydes by condensation. The results showed that 2,3-diaminobenzamide and aldehydes could react under visible light irradiation at ambient temperature in the presence of PYTZ and pumping air (or other oxidant) to obtain the desired compound with simple workup. The structures of 20 synthesized compounds were determined by NMR, IR and HRMS (new compound) techniques. The method was efficient, metal free, green, and selective.
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Project supported by the Jiangsu Prospective Joint Research Project (No. BY2016066-02) and College Students Innovation Project (No. 201410324014Z).
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Zhang, LJ., Yang, K., Li, CY. et al. A simple and metal-free one-pot synthesis of 2-substituted-1H-4-carboxamide benzimidazole using 3,6-di(pyridin-2-yl)-1,2,4,5-tetrazine(PYTZ) as catalyst. Chem. Pap. 73, 2697–2705 (2019). https://doi.org/10.1007/s11696-019-00821-x
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DOI: https://doi.org/10.1007/s11696-019-00821-x