Abstract
β-Methoxycarbonyl-γ-butyrolactones bearing a γ-aromatic substituent were prepared via copper-catalyzed reductive aldol addition/lactonization domino reactions of ketones with α,β-unsaturated dicarboxylate esters and a silane under ambient temperature. The reaction has advantage of using readily available reagents, mild conditions and high efficiency.
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Funding was provided by Natural Science Foundation of Liaoning Province (CN) (Grant No: 2015020678).
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Li, R., Li, Z., Jiang, L. et al. An efficient synthesis of β-methoxycarbonyl-γ-butyrolactones. Chem. Pap. 71, 1825–1828 (2017). https://doi.org/10.1007/s11696-017-0175-y
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DOI: https://doi.org/10.1007/s11696-017-0175-y