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The Short-Term Effects of Roux-en-Y Gastric Bypass on Renal Excretion of Sodium and Its Association with Blood Pressure

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Abstract

Introduction

Bariatric surgery has been shown to be effective in reducing weight and has benefits, such as lowering blood pressure. An increase in urinary sodium excretion has been suggested as a possible mechanism. This study explored changes in sodium excretion and their correlation with blood pressure after Roux-en-Y gastric bypass.

Materials and Methods

This study was conducted on 28 obese participants with body mass index (BMI) of 44.54 ± 7.81 kg/m2 who underwent gastric bypass. Before surgery and at the third and sixth months after gastric bypass, blood pressure, urinary sodium concentration, 24-hour (24-h) urinary sodium excretion, and fractional excretion of sodium were evaluated. In addition, serum sodium and potassium levels were determined. Nonparametric tests were used to analyze the data.

Results

Blood pressure decreased after surgery and remained at low levels over the 3- and 6-month periods. The urinary sodium concentration increased at 3 months after surgery; however, the 24-h urinary sodium excretion and urine volume decreased. Interestingly, although some associations between variables were observed, significant correlations between the 24-h urinary sodium excretion and the systolic, diastolic, and mean blood pressures were found. In addition, the urine volume was higher in the sixth month than in the third month following surgery.

Conclusions

In the months immediately following surgery, a low-salt and low-volume diet favors decreases in urine volume and 24-h urinary sodium excretion. In addition, in the sixth month after surgery, an association between blood pressure and 24-h urinary sodium excretion was observed.

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Authors and Affiliations

  1. Department of Continuous Admission Service, Hospital of Specialties at La Raza National Medical Center, IMSS, Seris y Zaachila Col La Raza Del Azcapotzalco, 23065, Mexico City, Mexico

    Josue Emiliano López-Martínez

  2. Director of Education and Research in Health, Hospital of Specialties at XXI Century National Medical Center, IMSS, Cuauhtémoc 330, Colonia Doctores, 02070, Mexico City, Mexico

    Adolfo Chávez-Negrete

  3. Department of General and Bariatric Surgery, Hospital of Specialties at XXI Century National Medical Center, IMSS, Cuauhtémoc 330, Colonia Doctores, 02070, Mexico City, Mexico

    Arturo Abraham Rodríguez-González

  4. Department of Endocrinology and Obesity Clinic, Hospital of Specialties at XXI Century National Medical Center, IMSS, Cuauhtémoc 330, Colonia Doctores, 02070, Mexico City, Mexico

    Mario Antonio Molina-Ayala

  5. Central Chemistry Laboratories, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico

    Silvia Villanueva-Recillas

  6. Department of Clinical Investigation, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico

    Pablo Maravilla

  7. Obesity and Metabolic Clinic, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico

    Aida Monserrat Reséndiz-Barragán

  8. Department of General and Endoscopic Surgery, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico

    Enrique Rentería-Palomo

  9. Department of Endoscopic, Minimally Invasive Gastrointestinal and Bariatric Surgery, General Hospital Dr. Manuel Gea González, CdMX. Calzada de Tlalpan 4800. Col. Sección XVI, 14050, Mexico City, Mexico

    Martín Edgardo Rojano-Rodríguez

Authors
  1. Josue Emiliano López-Martínez
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  2. Adolfo Chávez-Negrete
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  3. Arturo Abraham Rodríguez-González
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  4. Mario Antonio Molina-Ayala
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  5. Silvia Villanueva-Recillas
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  6. Pablo Maravilla
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  7. Aida Monserrat Reséndiz-Barragán
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  8. Enrique Rentería-Palomo
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  9. Martín Edgardo Rojano-Rodríguez
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Corresponding author

Correspondence to Martín Edgardo Rojano-Rodríguez.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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López-Martínez, J.E., Chávez-Negrete, A., Rodríguez-González, A.A. et al. The Short-Term Effects of Roux-en-Y Gastric Bypass on Renal Excretion of Sodium and Its Association with Blood Pressure. OBES SURG 30, 102–110 (2020). https://doi.org/10.1007/s11695-019-04134-6

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  • DOI: https://doi.org/10.1007/s11695-019-04134-6

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