Abstract
Purpose: The study aimed to unravel abnormal cerebral blood flow (CBF) in patients with Leber’s hereditary optic neuropathy (LHON) using arterial spin labeling (ASL) and to investigate the associations among disrupted CBF, disease duration, and neuro-ophthalmological impairment. Methods: ASL perfusion imaging data was collected from 20 patients with acute LHON, 29 patients with chronic LHON, and 37 healthy controls. We used a one-way analysis of covariance to test the intergroup differences in CBF. Linear and nonlinear curve fit models were applied to explore the associations among CBF, disease duration, and neuro-ophthalmological metrics. Results: Brain regions differed in LHON patients, including the left sensorimotor and bilateral visual areas (p < 0.05, cluster-wise family-wise error correction). Acute and chronic LHON patients demonstrated lower CBF in bilateral calcarine than the healthy controls. Chronic LHON had lower CBF in the left middle frontal gyrus and sensorimotor cortex, and temporal-partial junction than the healthy controls and acute LHON. A significant logarithmic negative correlation was shown between CBF of left middle frontal gyrus and disease duration. A significant linear positive correlation was found between retinal nerve fiber layer thickness and CBF in left middle frontal gyrus, and negative correlations between loss of variance and CBF in left middle frontal gyrus and sensorimotor cortex (p < 0.05, Bonferroni correction). Conclusion: LHON patients exhibited reduced CBF in the visual pathway, sensorimotor and higher-tier cognitive areas. Disease duration and neuro-ophthalmological impairments can influence the metabolism of non-visual areas.
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Data Availability
The individual original MRI data will not be shared with the public because the subjects’ signed permission of personal data spread had not been approved. We promised that the imaging protocols and statistical analysis results would be accessed to public once the draft has been accepted for publication. Any reader can get the shareable data by email to the corresponding author.
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Acknowledgements
We appreciated members of the Department of Radiology & Tianjin Key Lab of Functional Imaging of Tianjin Medical University General Hospital for their technical support. We also appreciated members of the Department of Radiology of Henan Provincial People’s Hospital for data collection.
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This work was supported by the National Natural Science Foundation of China (81971599, 81771818, 82030053, 81271534, 81601473), National Key Research and Development Program of China (2018YFC1314300), Natural Science Foundation of Tianjin City (19JCYBJC25100), and Postdoctoral Research Foundation of China (2017M611175).
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Wen Qin and Chunshui Yu designed research; Yi Ji, Ling Wang and Hao Ding performed research; Yi Ji, Ling Wang, Qin Tian, Dapeng Shi and Ke Fan analyzed data; Yi Ji and Ling Wang wrote the paper. Wen Qin is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
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Wang, L., Ji, Y., Ding, H. et al. Abnormal cerebral blood flow in patients with Leber’s hereditary optic neuropathy. Brain Imaging and Behavior 17, 471–480 (2023). https://doi.org/10.1007/s11682-023-00775-5
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DOI: https://doi.org/10.1007/s11682-023-00775-5