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Cerebellar ataxia in patients with Leber's hereditary optic neuropathy

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Abstract

We report the cases of a mother and son with Leber's hereditary optic neuropathy (LHON), where a point mutation of mitochondria DNA from guanine to adenine on nucleotide position 11778 was verified. Both also had cerebellar ataxia and dysarthria and in both cases cerebellar atrophies were detected by computed tomography or magnetic resonance imaging. It was not possible to elucidate the relationship between LHON and the cerebellar atrophy, but it should be kept in mind that various neurological complications may occur in LHON.

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Authors and Affiliations

  1. Division of Neurology, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, 701-01, Kurashiki, Okayama, Japan

    Itaru Funakawa, Hiroshi Kato & Akira Terao

  2. Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, 701-01, Kurashiki, Okayama, Japan

    Kosuke Ichihashi & Sachio Kawashima

  3. Department of Bacteriology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Hyogo, Japan

    Tomoko Hayashi

  4. Department of Ophthalmology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Hyogo, Japan

    Kazumi Mitani & Shigeo Miyazaki

Authors
  1. Itaru Funakawa
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  2. Hiroshi Kato
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  3. Akira Terao
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  4. Kosuke Ichihashi
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  5. Sachio Kawashima
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  6. Tomoko Hayashi
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  7. Kazumi Mitani
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  8. Shigeo Miyazaki
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Funakawa, I., Kato, H., Terao, A. et al. Cerebellar ataxia in patients with Leber's hereditary optic neuropathy. J Neurol 242, 75–77 (1995). https://doi.org/10.1007/BF00887819

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  • DOI: https://doi.org/10.1007/BF00887819

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