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The influence of interoceptive awareness on functional connectivity in patients with irritable bowel syndrome

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Abstract

Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity likely related to altered processing of sensory stimuli along the brain-gut axis. Previous neuroimaging studies demonstrated structural and functional alteration of several brain areas involved in bodily representation, e.g. the insula, in patients with IBS. By means of resting-state functional magnetic resonance imaging (rs-fMRI) we searched for alteration of functional connectivity within the network involved in self-bodily consciousness. We found significant inverse correlation between hypochondriasis assessed through a clinical questionnaire and connectivity between posterior cingulate cortex and left supramarginal gyrus, extending into the adjacent superior temporal gyrus. Moreover, we observed a significant and positive correlation between a clinical questionnaire assessing interoception and connectivity between left anterior ventral insula and two clusters located in supramarginal gyrus bilaterally.

Our findings highlight an “abnormal network synchrony” reflecting functional alteration, in the absence of structural and micro-structural changes, which might represent a possible therapeutic target for Irritable Bowel Syndrome.

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Abbreviations

IBS:

Irritable Bowel Syndrome

RS-FMRI:

Resting-State Functional Magnetic Resonance Imaging

RS-FC:

Resting State Functional Connectivity

PCC:

Posterior Cingulate Cortex

TPJ:

Temporo Parietal Junction

lVAIC:

Left Ventral Anterior Insular Cortex

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Authors and Affiliations

  1. Department of Psychology, Second University of Naples, Viale Ellittico, 31, Caserta, Italy

    Mariachiara Longarzo, C. Cimminiello, L. Trojano & D. Grossi

  2. National Research Council, Institute of Biostructure and Bioimaging, Naples, Italy

    M. Quarantelli

  3. IRCCS SDN, Naples, Italy

    M. Aiello

  4. Division of Hepato-Gastroenterology Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy

    M. Romano, A. Del Prete & C. Loguercio

  5. Department of Advanced Biomedical Sciences, University “Federico II, Naples, Italy

    S. Cocozza & G. Olivo

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  1. Mariachiara Longarzo
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  2. M. Quarantelli
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  3. M. Aiello
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  11. D. Grossi
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Correspondence to Mariachiara Longarzo.

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Funding

This study did not receive any external funding.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Local Ethics Committee (Second University of Naples).

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Informed consent was obtained from all individual participants included in the study.

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Longarzo, M., Quarantelli, M., Aiello, M. et al. The influence of interoceptive awareness on functional connectivity in patients with irritable bowel syndrome. Brain Imaging and Behavior 11, 1117–1128 (2017). https://doi.org/10.1007/s11682-016-9595-5

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