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Menarche age exceed 17 years and menopausal age smaller than 48 years may affect prevalence of osteoporosis for Chinese women

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Abstract

Summary

In this work, we used a cross-sectional study to evaluate influence of menarche age, menstrual cycle, menstrual period, menopausal age, and menopause years for osteoporosis in women from China. We found that different menarche age, menstrual cycle, menopausal years, and menopausal age are related with the prevalence of osteoporosis. However, menarche age exceeds 17 years and menopausal age smaller than 48 years are risk factors for osteoporosis in women.

Study design

A cross-sectional, population-based study.

Purpose

The purpose of this study was to explore relationship between prevalence of osteoporosis and menarche age, menstrual cycle, menstrual period, menopausal age, and menopause years for women.

Methods

From March to October 2016, the cluster sampling method was used to conduct an osteoporosis-related questionnaire survey on women aged 40–80 in two communities in Lanzhou City, Gansu, China, and bone mineral density(BMD)was carried out using the DTX-200 dual-energy X-ray absorptiometer produced by the US OSTEOMETER company. The relationship between prevalence of osteoporosis and menarche age, menstrual cycle, menstrual period, menopausal age, and menopause years were analyzed using logistic regression analysis.

Results

There were 2224 female participates enrolled in this study and average age was 61.60 ± 8.05 years and total rate of prevalence was 32.73%; among them, different menarche age, menstrual cycle, menopausal years, and menopausal age have statistical differences with the prevalence of osteoporosis, but there is no statistical difference between different menstruation and the prevalence of osteoporosis. Single logistic regression analysis found that older menarche age, earlier menopausal age, and longer menopausal years were related factors for the prevalence of osteoporosis, while menarche age exceed 17 years and menopausal age smaller than 48 years are risk factors for osteoporosis for women in multivariate regression analysis.

Conclusions

In China, ages at menarche and menopause are associated with prevalence of osteoporosis. Later, menarche and earlier menopause are associated with higher osteoporosis risk. Menarche and menopause history may help identify women with increased risk of developing osteoporosis.

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Funding

This study was supported by National Administration of Traditional Chinese Medicine, China.

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Authors and Affiliations

  1. Department of Orthopedics, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, China

    Yong He, Jin Huang, Guopeng Jiang, Huaming Wang, Jun Zhao, Zhilong Chen, Chen Zhang, Shihai Chen & Weiping Li

  2. Second Provincial People’s Hospital of Gan Su, Lanzhou, Gansu, China

    Dingpeng Li & Xingwen Xie

Authors
  1. Yong He
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  2. Jin Huang
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  3. Guopeng Jiang
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  4. Huaming Wang
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  5. Jun Zhao
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  6. Zhilong Chen
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  7. Chen Zhang
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  8. Shihai Chen
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  9. Weiping Li
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  10. Dingpeng Li
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  11. Xingwen Xie
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Contributions

All authors make the same contribution. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to Yong He.

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Ethics approval and consent to participate

Ethics approval was granted through Gansu Provincial Hospital of Traditional Chinese Medicine (2016–047-01) and all centers’ ethics review boards.

All participants gave written informed consent and the study is conducted in accordance with the Helsinki Declaration.

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None.

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He, Y., Huang, J., Jiang, G. et al. Menarche age exceed 17 years and menopausal age smaller than 48 years may affect prevalence of osteoporosis for Chinese women. Arch Osteoporos 16, 123 (2021). https://doi.org/10.1007/s11657-021-00959-w

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