Skip to main content

Advertisement

Log in

Unhealthy lifestyles are associated with the increased risk of low-energy fracture in Chinese men ≥ 50 years, a population-based survey

  • Original Article
  • Published:
Archives of Osteoporosis Aims and scope Submit manuscript

ABSTRACT

Purpose

This study aims to investigate the incidence of low-energy fractures in men aged 50 years and older in China and to explore associated risk factors.

Methods

All the relevant data were available from the China National Fracture Survey (CNFS), which was a cross-sectional survey carried out in eight Chinese provinces (municipalities) between January and May 2015.

Results

Through 2014, 76,687 men above 50 years participated in this study and 223 participants had low-energy fractures, indicating the incidence rate 290.8 (95%CI, 252.7–328.9)/100,000 men. Over 80% of the fractures occurred at home and on the common road. The fracture incidence rate presented a significant rising trend with advanced age (p = 0.039). Current smoking, alcohol overconsumption, insufficient sleep duration, and history of past fracture were identified as significant risk factors associated with low-energy fracture (p < 0.05).

Conclusions

These results will assist the decisions regarding allocation of healthcare provision to populations of greatest need and aid the design and implementation of strategies to reduce fracture incidence. Accordingly, individuals should be encouraged to reduce alcohol consumption, immediately quit smoking, and get sufficient sleep, especially in those with a history of past fracture. In addition, primary preventives especially home prevention should be emphasized.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Riggs BL, Melton LJ 3rd (1986) Involutional osteoporosis. N Engl J Med 314:1676–1686

    Article  CAS  Google Scholar 

  2. Pinheiro MDM, Camargos BM, Borba VZC, Lazaretticastro M (2009) FRAX TM: building an idea to Brazil. Arq Bras Endocrinol Metab 53:783–790

    Article  Google Scholar 

  3. Pinheiro MM, Eis SR (2010) Epidemiology of osteoporotic fractures in Brazil: what we have and what we need. Arq Bras Endocrinol Metab 54:164–170

    Article  Google Scholar 

  4. Chen W, Lv H, Liu S, Liu B, Zhu Y, Chen X, Yang G, Liu L, Zhang T, Wang H, Yin B, Guo J, Zhang X, Li Y, Smith D, Hu P, Sun J, Zhang Y (2017) National incidence of traumatic fractures in China: a retrospective survey of 512 187 individuals. Lancet Glob Health 5:e807–e817

    Article  Google Scholar 

  5. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005&ndash;2025. J Bone Miner Res Off J Am Soc Bone Miner Res 22:465–475

    Article  Google Scholar 

  6. Statement NIH Consensus (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285: 785–795

  7. Adachi JD, Ioannidis G, Pickard L, Berger C, Prior JC, Joseph L, Hanley DA, Olszynski WP, Murray TM, Anastassiades T, Hopman W, Brown JP, Kirkland S, Joyce C, Papaioannou A, Poliquin S, Tenenhouse A, Papadimitropoulos EA (2003) The association between osteoporotic fractures and health-related quality of life as measured by the health utilities index in the Canadian multicentre osteoporosis study (CaMos). Osteoporos Int 14:895–904

    Article  CAS  Google Scholar 

  8. Johnell O, Kanis J (2006) Epidemiology of osteoporotic fractures. Osteoporos Osteoporos Rheum Dis 16:1–13

    Google Scholar 

  9. Kanis JA, Johnell O, Oden A, Johansson H, Mccloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397

    Article  CAS  Google Scholar 

  10. Lesnyak O, Ershova O, Belova K, Gladkova E, Sinitsina O, Ganert O, Romanova M, Khodirev V, Johansson H, McCloskey E, Kanis JA (2012) Epidemiology of fracture in the Russian Federation and the development of a FRAX model. Arch Osteoporos 7:67–73

    Article  Google Scholar 

  11. Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int 3:120–126

    Article  CAS  Google Scholar 

  12. Ahn SK, Kam S, Chun BY (2014) Incidence of and factors for self-reported fragility fractures among middle-aged and elderly women in rural Korea: an 11-year follow-up study. J Prev Med Public Health 47:289–297

    PubMed  PubMed Central  Google Scholar 

  13. Huang C, Ross PD, Fujiwara S, Davis JW, Epstein RS, Kodama K, Wasnich RD (1996) Determinants of vertebral fracture prevalence among native Japanese women and women of japanese descent living in Hawaii. Bone 18:437–442

    Article  CAS  Google Scholar 

  14. Abrahamsen B, Jørgensen NR, Schwarz P (2015) Epidemiology of forearm fractures in adults in Denmark: national age- and gender-specific incidence rates, ratio of forearm to hip fractures, and extent of surgical fracture repair in inpatients and outpatients. Osteoporos Int 26:67–76

    Article  CAS  Google Scholar 

  15. Diamantopoulos AP, Rohde G, Johnsrud I, Skoie IM, Hochberg M, Haugeberg G (2012) The epidemiology of low- and high-energy distal radius fracture in middle-aged and elderly men and women in southern Norway. PLoS One 7:e43367

    Article  CAS  Google Scholar 

  16. Tai SY, Wu IC, Wu DC, Su HJ, Huang JL, Tsai HJ, Lu CY, Lee JM, Wu MT (2010) Cigarette smoking and alcohol drinking and esophageal cancer risk in Taiwanese women. World J Gastroenterol 16:1518–1521

    Article  Google Scholar 

  17. Hughes A, Sathe N, Spagnola K (2008) State estimates of substance use from the 2005-2006 National Surveys on Drug Use and Health. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Office of Applied Studies, 2008. [Available at http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.164.510&rep=rep1&type=pdf]

  18. Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733

    Article  CAS  Google Scholar 

  19. Brennan SL, Holloway KL, Williams LJ, Kotowicz MA, Bucki-Smith G, Moloney DJ, Dobbins AG, Timney EN, Pasco JA (2015) The social gradient of fractures at any skeletal site in men and women: data from the Geelong osteoporosis study fracture grid. Osteoporos Int 26:1351–1359

    Article  CAS  Google Scholar 

  20. Wright NC, Saag KG, Curtis JR, Smith WK, Kilgore ML, Morrisey MA, Yun H, Zhang J, Delzell ES (2012) Recent trends in hip fracture rates by race/ethnicity among older US adults. J Bone Miner Res 27:2325–2332

    Article  Google Scholar 

  21. Curtis EM, van der Velde R, Moon RJ, van den Bergh JPW, Geusens P, de Vries F, van Staa TP, Cooper C, Harvey NC (2016) Epidemiology of fractures in the United Kingdom 1988-2012: variation with age, sex, geography, ethnicity and socioeconomic status. Bone 87:19–26

    Article  Google Scholar 

  22. Amin S, Achenbach SJ, Atkinson EJ, Khosla S, Melton LJ 3rd. (2014) Trends in fracture incidence: a population-based study over 20 years. J Bone Miner Res 29:581–589. https://doi.org/10.1002/jbmr.2072

    Article  PubMed  PubMed Central  Google Scholar 

  23. Dettoni F, Peveraro A, Dettoni A, Rossi R, Castoldi F, Zareh A, Amberti F, Giai Via A, Bonasia D (2012) Erratum to: epidemiology of hip fractures in northwestern Italy: a multicentric regional study on incidence of hip fractures and their outcome at 3-year follow-up. Musculoskelet Surg 96:47–47

    Article  Google Scholar 

  24. Høiberg MP, Gram J, Hermann P, Brixen K, Haugeberg G (2014) The incidence of hip fractures in Norway –accuracy of the national Norwegian patient registry. BMC Musculoskelet Dis 15:372

    Article  Google Scholar 

  25. Icks A et al (2013) Incidence of hip fractures in Germany, 1995-2010. Arch Osteoporos 8:1–7

    Article  Google Scholar 

  26. Hagino H (2007) Features of limb fractures: a review of epidemiology from a Japanese perspective. J Bone Miner Metab 25:261–265

    Article  Google Scholar 

  27. Hagino H, Katagiri H, Okano T, Yamamoto K, Teshima R (2005) Increasing incidence of hip fracture in Tottori prefecture, Japan: trend from 1986 to 2001. Osteoporos Int 16:1963–1968

    Article  Google Scholar 

  28. Yoon BH, Lee YK, Kim SC, Kim SH, Ha YC, Koo KH (2013) Epidemiology of proximal femoral fractures in South Korea. Arch Osteoporos 8:157

    Article  Google Scholar 

  29. Sang-Rim K et al (2010) Incidence of hip fractures in Jeju Island, South Korea: a prospective study (2002-2006). Clin Orthop Surg 2:64–68

    Google Scholar 

  30. Kanis JA, Johnell O, Oden A, Johansson H, de Laet C, Eisman JA, Fujiwara S, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Pols H, Reeve J, Silman A, Tenenhouse A (2005) Smoking and fracture risk: a meta-analysis. Osteoporos Int 16:155–162

    Article  CAS  Google Scholar 

  31. Lutfy K, Aimiuwu O, Mangubat M, Shin CS, Nerio N, Gomez R, Liu Y, Friedman TC (2012) Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. J Neurochem 120:1108–1116

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Rasmussen DD (1998) Effects of chronic nicotine treatment and withdrawal on hypothalamic proopiomelanocortin gene expression and neuroendocrine regulation. Psychoneuroendocrinology 23:245–259

    Article  CAS  Google Scholar 

  33. Scholes S, Panesar S, Shelton NJ, Francis RM, Mirza S, Mindell JS, Donaldson LJ (2014) Epidemiology of lifetime fracture prevalence in England: a population study of adults aged 55 years and over. Age Ageing 43:234–240. https://doi.org/10.1093/ageing/aft167

    Article  PubMed  Google Scholar 

  34. Kanis JA, Johansson H, Johnell O, Oden A, de Laet C, Eisman JA, Pols H, Tenenhouse A (2005) Alcohol intake as a risk factor for fracture. Osteoporos Int 16:737–742

    Article  Google Scholar 

  35. Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, Hillier TA, Schneider J, Claman D, Cummings SR (2008) Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med 168:1768–1775

    Article  Google Scholar 

  36. Holmberg AH, Johnell O, Nilsson PM, Nilsson J, Berglund G, Åkesson K (2006) Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women. Osteoporos Int 17:1065–1077

    Article  CAS  Google Scholar 

  37. Kanis JA, Johnell O, de Laet C, Johansson H, Oden A, Delmas P, Eisman J, Fujiwara S, Garnero P, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Pols H, Reeve J, Silman A, Tenenhouse A (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375–382. https://doi.org/10.1016/j.bone.2004.03.024

    Article  CAS  PubMed  Google Scholar 

  38. Klotzbuecher CM, Ross PD, Landsman PB, Berger M (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–739

    Article  CAS  Google Scholar 

  39. Wilsgaard T, Emaus N, Ahmed LA, Grimnes G, Joakimsen RM, Omsland TK, Berntsen GR (2009) Lifestyle impact on lifetime bone loss in women and men: the Tromsø study. Am J Epidemiol 169:877–886

    Article  Google Scholar 

  40. Lu X, Siu KC, Fu SN, Hui-Chan CW, Tsang WW (2016) Effects of Tai chi training on postural control and cognitive performance while dual tasking - a randomized clinical trial. J Complement Integr Med 13:181–187

    PubMed  Google Scholar 

Download references

Acknowledgments

We are grateful to Q Zhang and H Wang of the Department of Orthopedics, and to X Zhang of the Department of statistics and epidemiology for their kind assistance.

Funding

This study was funded by the Hebei Province Medical Science Special Major Projects Research Fund.

Author information

Authors and Affiliations

Authors

Contributions

Y Zhang conceived the idea for the study. Y Zhang, Y Zhang, YL, YZ, SL, WC, and HL and designed the study. JS, YZ and XZ performed the statistical analyses. XX, YL, YZ, and CJ prepared the figures and tables. YL, YZ, JS, SL, WC, HL, and CJ interpreted the data and contributed to preparation of the manuscript. GL, YL, and YZ contributed equally to this manuscript.

Corresponding author

Correspondence to Yingze Zhang.

Ethics declarations

The CNFS was approved by the Institutional Review Board of the 3rd Hospital of Hebei Medical University. Written informed consent was obtained from each participant before data collection.

Conflict of interest

The authors declare that they have no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This study is registered with the Chinese Clinical Trial Registry, number ChiCTR-EPR-15005878.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, G., Li, Y., Zhu, Y. et al. Unhealthy lifestyles are associated with the increased risk of low-energy fracture in Chinese men ≥ 50 years, a population-based survey. Arch Osteoporos 14, 57 (2019). https://doi.org/10.1007/s11657-019-0600-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11657-019-0600-7

Keywords

Navigation