Abstract
Objective
To investigate the effect of Huanshuai Recipe Oral Liquid (缓衰口服液, HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis (ARAS).
Methods
A total of 52 ARAS patients with the Chinese medicine (CM) syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group (36 cases) and the control group (16 cases). Both groups received a basic treatment (high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.). In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function (serum creatinine, blood urea nitrogen and uric acid) and blood lipids (cholesterol, triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular fifiltration rate (eGFR) and CM syndrome score were compared between groups.
Results
After treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were signifificantly decreased (P<0.05 or P<0.01), and the eGFR in the treatment group were significantly increased (P<0.05).
Conclusion
HSR can effectively improve the renal function and clinical symptoms of ARAS patients.
Similar content being viewed by others
References
Seddon M, Saw J. Atherosclerotic renal artery stenosis: review of pathophysiology, clinical trial evidence, and management strategies. Can J Cardiol 2011;27:468–480.
Wang F, Wang M, Wang HY. Patients with atherosclerotic renal artery stenosis prevalence survey. Chin J Nephrol (Chin) 2005;21:139–142.
Mailloux LU, Napolitano B, Bellucci AG, Vernace M, Wilkes BM, Mossey RT. Renal vascular disease causing endstage renal disease, incidence, clinical correlates, and outcomes: a 20-year clinical experience. Am J Kidney Dis 1994;24:622–629.
de Mast Q, Beutler JJ. The prevalence of atherosclerotic renal artery stenosisi in risk groups: a systematic literature review. J Hypertens 2009;27:1333–1340.
Kalra PA, Guo H, Kausz AT, Gilbertson DT, Liu JN, Chen SC, et al. Atherosclerotic renovascular disease in United States patients aged 67 years or older: risk factors, revascularization, and prognosis. Kidney Int 2005;68:293–301.
Rao XR, Zhang NN, Li S. Preliminary research of syndrome of traditional Chinese medicine on atherosclerotic renal artery stenosis. Chin J Integr Tradit West Med (Chin) 2010;11:125–127.
Li S, Rao XR, Song JY, Meng LQ, Qu L, Li XM. Effects of Huanshuai Recipe Oral Liquid on restructuring glomerular microvasculature and expression of vascular endothelial growth factor in subtotal nephrectomized rats. Chin J Integr Med 2010;16:239–246.
Li S, Rao XR, Dai XW. The clinical observation of longterm curative efficacy of Huanshuai Recipe Oral Solution in treating 35 patients with chronic renal failure. J Tradit Chin Med (Chin) 2001;42:164–166.
Rundback JH, Sacks D, Kent KC, Cooper C, Jones D, Murphy T, et al. American Heart Association. Guidelines for the reporting of renal artery revascularization in clinical trials. Circulation 2002;106:1572–1585.
National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002;39(2 Suppl 1):S1-S266.
Zheng XY, ed. Guiding principles for clinical research on new drugs of traditional Chinese medicine (trial). Beijing: China Medical Science Press; 2002:163–168.
Mitch WE, Walser M, Buffington GA, Lemann J Jr. A simple method of estimating progression of chronic renal failure. Lancet 1976;2:1326–1328.
Lerman L, Textor S, Grande J. Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond. Progr Cardiovasc Dis 2009;52:196–203.
The ASTRAL Investigators. Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med 2009;361:1953-1962.
Sos TA. After ASTRAL and STAR—Whither renal artery stenting? Intervent Med Appl Sci 2010;2:153–158.
Dubel G, Murphy T. The role of percutaneous revascularization for renal artery stenosis. Vasc Med 2008;13:141–156.
Adalakha S, Greco B, Dart R, Shepherd A, Murphy T, Jamerson K, et al. Pressure control in patients with renal artery stenosis, preliminary results of the CORAL clinical trial. Circulation 2010;122:A17234.
Zhang NN, Rao XR. Therapy option for renal artery stenosis: percutaneous revascularization or medical treatment? Chin J Integr Tradit West Nephrol (Chin) 2009;10:261–263.
Li XX, Rao XR. Treatment of atherosclerotic renal artery stenosis. Chin J Inform Tradit Chin Med (Chin) 2009;2:90–91.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, Xj., Rao, Xr., Li, S. et al. Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis. Chin. J. Integr. Med. 21, 811–816 (2015). https://doi.org/10.1007/s11655-015-2046-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11655-015-2046-0