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La profilassi antibiotica nelle fratture esposte: la proposta per un nuovo PDTA

Antibiotic prophylaxis in open fractures: our proposal for a new diagnostic-therapeutic protocol

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LO SCALPELLO-OTODI Educational

Abstract

As shown by the studies of Gustilo–Anderson, infections are one of the most frequent complications in open fractures, owing to the heavy contamination of tissue during the trauma. Therefore, an immediate antibiotic prophylaxis capable of covering the majority of microbes involved in this type of contamination is needed. In this paper we address this need by proposing a diagnostic-therapeutic protocol.

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Bibliografia

  1. Gustilo RB, Anderson JT (1976) Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Jt Surg, Am 58(4):453–458

    Article  CAS  Google Scholar 

  2. Carver DC, Kuehn SB, Weinlein JC (2017) Role of systemic and local antibiotics in the treatment of open fractures. Orthop Clin N Am 48(2):137–153

    Article  Google Scholar 

  3. Isaac SM, Woods A, Danial IN, Mourkus H (2016) Antibiotic prophylaxis in adults with open tibial fractures: what is the evidence for duration of administration? A systematic review. J Foot Ankle Surg 55(1):146–150

    Article  PubMed  Google Scholar 

  4. Dunkel N, Pittet D, Tovmirzaeva L et al. (2013) Short duration of antibiotic prophylaxis in open fractures does not enhance risk of subsequent infection. Bone Jt J 95-B(6):831–837

    Article  CAS  Google Scholar 

  5. Giesecke MT, Schwabe P, Wichlas F et al. (2014) Impact of high prevalence of pseudomonas and polymicrobial gram-negative infections in major sub-/total traumatic amputations on empiric antimicrobial therapy: a retrospective study. World J Emerg Surg 9:55

    Article  PubMed  PubMed Central  Google Scholar 

  6. Chen AF, Schreiber VM, Washington W et al. (2013) What is the rate of methicillin-resistant staphylococcus aureus and gram-negative infections in open fractures? Clin Orthop Relat Res 471(10):3135–3140

    Article  PubMed  PubMed Central  Google Scholar 

  7. Andreoni F, Zürcher C, Tarnutzer A et al. (2017) Clindamycin affects group A Streptococcus virulence factors and improves clinical outcome. J Infect Dis 215(2):269–277

    CAS  PubMed  Google Scholar 

  8. Schintler MV, Traunmüller F, Metzler J et al. (2009) High fosfomycin concentrations in bone and peripheral soft tissue in diabetic patients presenting with bacterial foot infection. J Antimicrob Chemother 64(3):574–578

    Article  CAS  PubMed  Google Scholar 

  9. Naique SB (2006) Management of severe open tibial fractures: the need for combined orthopaedic and plastic surgical treatment in specialist centres. J Bone Jt Surg, Br 88(3):351–357

    Article  CAS  Google Scholar 

  10. Otchwemah R, Grams V, Tjardes T et al. (2015) Bacterial contamination of open fractures—pathogens, antibiotic resistances and therapeutic regimes in four hospitals of the trauma network Cologne, Germany. Injury 46(Suppl 4):104–108

    Article  Google Scholar 

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Correspondence to E. Zamparini.

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Gli autori E. Zamparini, E. Castiello, E. Marchionni, N. Rossi, G. Fornaro, C. Pungetti, D. Tigani e P. Viale dichiarano di non aver alcun conflitto di interesse.

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Tutte le procedure descritte nello studio e che hanno coinvolto esseri umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Essendo uno studio puramente descrittivo, non è stato necessario acquisire il consenso informato dei pazienti.

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Zamparini, E., Castiello, E., Marchionni, E. et al. La profilassi antibiotica nelle fratture esposte: la proposta per un nuovo PDTA. LO SCALPELLO 33, 12–15 (2019). https://doi.org/10.1007/s11639-019-00306-2

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  • DOI: https://doi.org/10.1007/s11639-019-00306-2

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