Abstract
Objective
Ultrasonography (US) is the most commonly used radiological method in the diagnosis of gallbladder polyps (GBPs). Patients diagnosed with GBPs on US are operated on with risk factors that do not have a high level of evidence. Our aim in this study is to determine the sensitivity of US in diagnosis GBPs, to define risk factors for neoplastic (NP) polyps, and to develop the risk scoring system.
Materials and Methods
Between July 2011 and July 2021, 173 patients who were found to have GBPs in the pathology specimens after cholecystectomy were included in the study. Patients were divided into two groups: nonneoplastic and NP groups.
Results
GBPs in patients who underwent abdominal US for any reason was 4.5%. The sensitivity of US in the diagnosis of GBPs was 56.6%. Comparison between groups, age ≥50, presence of symptoms, polyp size >12.5mm, single polyp, concomitant gallstones, and gallbladder wall thickness ≥4mm were statistically in the NP group. A risk scoring system was developed using these values. If the risk score was <4, 0.6% of GBPs was NP polyps. If the risk score was ≥4, 63.2% of GBPs were NP polyps.
Conclusion
Our risk scoring system can prevent unnecessary choelcystectomy. Because the incidence of NP polyps in low-risk patients (risk score <4) is extremely rare.
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References
McCain RS, Diamond A, Jones C, Coleman HG. Current practices and future prospects for the management of gallbladder polyps: A topical review. World J Gastroenterol 2018;24(26):2844.
Metman MJ, Olthof PB, van der Wal JB, van Gulik TM, Roos D, Dekker JW. Clinical relevance of gallbladder polyps; is cholecystectomy always necessary?. Hpb. 2020;22(4):506-10.
Wiles R, Thoeni RF, Barbu ST, Vashist YK, Rafaelsen SR, Dewhurst C, Arvanitakis M, Lahaye M, Soltes M, Perinel J, Roberts SA. Management and follow-up of gallbladder polyps. Eur Radiol 2017 Sep;27(9):3856-66.
Gallahan WC, Conway JD. Diagnosis and management of gallbladder polyps. Gastroenterol Clin 2010;39(2):359-67.
Velidedeoğlu, M., Çitgez, B., Arıkan, A. E., & Ayan, F. (2017). Is it necessary to perform prophylactic cholecystectomy for all symptomatic gallbladder polyps diagnosed with ultrasound? Turkish J Surg, 33(1), 25.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R. Management and follow-up of gallbladder polyps: Updated joint guidelines between the ESGAR, EAES, EFISDS ESGE Eur Radiol 2021 17:1-1.
Aldouri AQ, Malik HZ, Waytt J, Khan S, Ranganathan K, Kummaraganti S, Hamilton W, Dexter S, Menon K, Lodge JP, Prasad KR. The risk of gallbladder cancer from polyps in a large multiethnic series. Eur J Surg Oncol (EJSO) 2009;35(1):48-51.
Myers RP, Shaffer EA, Beck PL. Gallbladder polyps: Epidemiology, natural history and management. Can J Gastroenterol 2002 ;16(3):187-94.
Yang HL, Sun YG, Wang Z. Polypoid lesions of the gallbladder: Diagnosis and indications for surgery. Journal of British surgery 1992;79(3):227-9.
Lee KF, Wong J, Li JC, San Lai PB. Polypoid lesions of the gallbladder. Am J Surg 2004 ;188(2):186-90.
Wennmacker, S. Z., Lamberts, M. P., Di Martino, M., Drenth, J. P., Gurusamy, K. S., & van Laarhoven, C. J. (2018). Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps. Cochrane Database Syst Rev, 8.
Akyürek N, Salman B, İrkörücü O, Şare M, Tatlicioǧlu E. Ultrasonography in the diagnosis of true gallbladder polyps: The contradiction in the literature. Hpb. 2005;7(2):155-8.
Sugiyama M, Atomi Y, Yamato T. Endoscopic ultrasonography for differential diagnosis of polypoid gall bladder lesions: Analysis in surgical and follow up series. Gut. 2000 ;46(2):250-4.
Cheon YK, Cho WY, Lee TH, Cho YD, Moon JH, Lee JS, Shim CS. Endoscopic ultrasonography does not differentiate neoplastic from non-neoplastic small gallbladder polyps. World J Gastroenterol: WJG 2009;15(19):2361.
Zhang, X., Wang, J. C., Wu, B., Li, T., Jin, L., Wu, Y., et al. Zhu C. A nomogram-based model to predict neoplastic risk for patients with gallbladder polyps
Christensen, A. H. (1970). Benign tumors and pseudotumors of the gallbladder. Report of 180 cases. Arch Pathol, 90, 423–432.
Dilek ON, Karasu S, Dilek FH. Diagnosis and treatment of gallbladder polyps: Current perspectives. Euroasian J Hepato-Gastroenterol 2019 Jan;9(1):40.
Andrén-Sandberg Å. Diagnosis and management of gallbladder polyps. N Am J Med Sci 2012 ;4(5):203.
Elmasry M, Lindop D, Dunne DF, Malik H, Poston GJ, Fenwick SW. The risk of malignancy in ultrasound detected gallbladder polyps: A systematic review. Int J Surg 2016 Sep 1;33:28-35.
Jones-Monahan KS, Gruenberg JC, Finger JE, Tong GK. Isolated small gallbladder polyps: An indication for cholecystectomy in symptomatic patients. Am Surg 2000;66(8):716.
French DG, Allen PD, Ellsmere JC. The diagnostic accuracy of transabdominal ultrasonography needs to be considered when managing gallbladder polyps. Surg Endosc 2013;27(11):4021-5.
Terzi C, Sökmen S, Seçkin S, Albayrak L, UĞurlu M. polypoid lesions of the gallbladder: Report of 100 cases with special reference to operative indications. Surgery 2000;127(6):622-7.
Kwon W, Jang JY, Lee SE, Hwang DW, Kim SW. Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer. J Korean Med Sci 2009;24(3):481-7.
Park JK, Yoon YB, Kim YT, Ryu JK, Yoon WJ, Lee SH, Yu SJ, Kang HY, Lee JY, Park MJ. Management strategies for gallbladder polyps: Is it possible to predict malignant gallbladder polyps?. Gut and liver 2008;2(2):88.
Bhatt NR, Gillis A, Smoothey CO, Awan FN, Ridgway PF. Evidence based management of polyps of the gall bladder: A systematic review of the risk factors of malignancy. Surgeon 2016 ;14(5):278-86.
Shin SR, Lee JK, Lee KH, Lee KT, Rhee JC, Jang KT, Kim SH, Choi DW. Can the growth rate of a gallbladder polyp predict a neoplastic polyp?. J Clin Gastroenterol 2009 ;43(9):865-8.
Kozuka S, Tsubone M, Yasui A, Hachisuka K. Relation of adenoma to carcinoma in the gallbladder. Cancer 1982; 50(10):2226-34.
Zhu JQ, Han DD, Li XL, Kou JT, Fan H, He Q. Predictors of incidental gallbladder cancer in elderly patients. Hepatobiliary Pancreatic Dis Int 2015;14(1):96-100.
Zielinski MD, Atwell TD, Davis PW, Kendrick ML, Que FG. Comparison of surgically resected polypoid lesions of the gallbladder to their pre-operative ultrasound characteristics. J Gastrointest Surg 2009; 13(1):19-25.
Kubota K, Bandai Y, Noie T, Ishizaki Y, Teruya M, Makuuchi M. How should polypoid lesions of the gallbladder be treated in the era of laparoscopic cholecystectomy?. Surgery. 1995; 117(5):481-7.
Lee SR, Kim HO, Shin JH. Reasonable cholecystectomy of gallbladder polyp–10 years of experience. Asian J Surg 2019;42(1):332-7.
Matos AS, Baptista HN, Pinheiro C, Martinho F. Gallbladder polyps: how should they be treated and when?. Revista da Associacao Medica Brasileira (1992). 2010;56(3):318-21.
Koga A, Watanabe K, Fukuyama T, Takiguchi S, Nakayama F. Diagnosis and operative indications for polypoid lesions of the gallbladder. Arch Surg 1988 ;123(1):26-9.
Onda, S., Futagawa, Y., Gocho, T., Shiba, H., Ishida, Y., Okamoto, T., & Yanaga, K. (2020). A preoperative scoring system to predict carcinoma in patients with gallbladder polyps. Dig Surg, 37(4), 275–281.
Szpakowski JL, Tucker LY. Outcomes of gallbladder polyps and their association with gallbladder cancer in a 20-year cohort. JAMA Netw Open 2020 ;3(5):e205143.
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Güneş, Y., Taşdelen, İ., Ergin, A. et al. A New Risk Scoring System to Predict Malignancy in Gallbladder Polyps: a Single-Center Study. J Gastrointest Surg 26, 1846–1852 (2022). https://doi.org/10.1007/s11605-022-05351-8
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DOI: https://doi.org/10.1007/s11605-022-05351-8