Skip to main content
SpringerLink
Log in

Contrast enhancement in cerebral adrenoleukodystrophy: a comparison of T1 TSE and MPRAGE sequences

  • Original Article
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To compare conventional T1 TSE with MPRAGE for enhancement detection in cerebral adrenoleukodystrophy (CALD).

Materials and methods

Contrast-enhanced T1 TSE and MPRAGE sequences of 34 CALD patients demonstrating enhancement were evaluated. Contrast ratios were calculated by drawing ROIs to the most enhancing part of demyelination and normal-appearing deep white matter on both T1 TSE and MPRAGE. A comparison was performed between ratios using paired T test.

Results

Mean age of 34 included male children was 8 (5–11 years). There was no statistically significant difference between T1 TSE and MPRAGE ratios. However, in 4 out of 34 examinations, minimal contrast enhancement was noted only in T1 TSE sequence.

Conclusion

Our data indicate that both T1 TSE and MPRAGE sequences are valuable in determining contrast enhancement in CALD. Although there is not a statistically significant difference between the two techniques, T1 TSE sequence appears to be more sensitive for low degree of enhancement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Engelen M, Kemp S, De Visser M, van Geel BM, Wanders RJ, Aubourg P. X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management. Orphanet J Rare Dis. 2012;7(1):1–14.

    Article  Google Scholar 

  2. de Beer M, Engelen M, van Geel BM. Frequent occurrence of cerebral demyelination in adrenomyeloneuropathy. Neurology. 2014;83(24):2227–31.

    Article  PubMed  Google Scholar 

  3. Van Geel BM, Bezman L, Loes DJ, Moser HW, Raymond GV. Evolution of phenotypes in adult male patients with X-linked adrenoleukodystrophy. Annal Neurol. 2001;49(2):186–94.

    Article  PubMed  Google Scholar 

  4. Eichler F, Mahmood A, Loes D, Bezman L, Lin D, Moser HW, et al. Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. Arch Neurol. 2007;64(5):659–64.

    Article  PubMed  Google Scholar 

  5. Mahmood A, Raymond GV, Dubey P, Peters C, Moser HW. Survival analysis of haematopoietic cell transplantation for childhood cerebral X-linked adrenoleukodystrophy: a comparison study. Lancet Neurol. 2007;6(8):687–92.

    Article  PubMed  Google Scholar 

  6. Moser H, Loes D, Melhem E, Raymond G, Bezman L, Cox CS, et al. X-Linked adrenoleukodystrophy: overview and prognosis as a function of age and brain magnetic resonance imaging abnormality. A study involving 372 patients. Neuropediatrics. 2000;31(05):227–39.

    Article  CAS  PubMed  Google Scholar 

  7. Mallack EJ, Turk BR, Yan H, Price C, Demetres M, Moser AB, et al. MRI surveillance of boys with X-linked adrenoleukodystrophy identified by newborn screening: Meta-analysis and consensus guidelines. J Inherit Metab Dis. 2021;44(3):728–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Melhem ER, Loes DJ, Georgiades CS, Raymond GV, Moser HW. X-linked adrenoleukodystrophy: the role of contrast-enhanced MR imaging in predicting disease progression. Am J Neuroradiol. 2000;21(5):839–44.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Uysal E, Erturk SM, Yildirim H, Seleker F, Basak M. Sensitivity of immediate and delayed gadolinium-enhanced MRI after injection of 0.5 M and 1.0 M gadolinium chelates for detecting multiple sclerosis lesions. Am J Roentgenol. 2007;188(3):697–702.

    Article  Google Scholar 

  10. Lo C-P, Kao H-W, Chen S-Y, Chu C-M, Hsu C-C, Chen Y-C, et al. Comparison of diffusion-weighted imaging and contrast-enhanced T1-weighted imaging on a single baseline MRI for demonstrating dissemination in time in multiple sclerosis. BMC Neurol. 2014;14(1):1–7.

    Article  Google Scholar 

  11. Meftahi G, PirzadJahromi G, Azari A, Ghaemmaghami P. Detection of active plaques in multiple sclerosis using 3 and 12 directional diffusion-weighted imaging: comparison with gadolinium-enhanced MR imaging. J Biomed Phys Eng. 2020;10(6):737.

    Google Scholar 

  12. Lund TC, Ng M, Orchard PJ, Loes DJ, Raymond GV, Gupta A, et al. Volume of gadolinium enhancement and successful repair of the blood-brain barrier in cerebral adrenoleukodystrophy. Biol Blood Marrow Transplant. 2020;26(10):1894–9.

    Article  CAS  PubMed  Google Scholar 

  13. Orchard PJ, Nascene DR, Miller WP, Gupta A, Kenney-Jung D, Lund TC. Successful donor engraftment and repair of the blood-brain barrier in cerebral adrenoleukodystrophy. Blood. 2019;133(12):1378–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Mugler JP III, Brookeman JR. Three-dimensional magnetization-prepared rapid gradient-echo imaging (3D MP RAGE). Magn Reson Med. 1990;15(1):152–7.

    Article  PubMed  Google Scholar 

  15. Ellingson BM, Wen PY, Cloughesy TF. Modified criteria for radiographic response assessment in glioblastoma clinical trials. Neurotherapeutics. 2017;14(2):307–20.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Danieli L, Riccitelli G, Distefano D, Prodi E, Ventura E, Cianfoni A, et al. Brain tumor-enhancement visualization and morphometric assessment: a comparison of MPRAGE, SPACE, and VIBE MRI techniques. Am J Neuroradiol. 2019;40(7):1140–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Mugler JP III, Brookeman JR. Theoretical analysis of gadopentetate dimeglumine enhancement in T1-weighted imaging of the brain: Comparison of two-dimensional spin-echo and three-dimensional gradient-echo sequences. J Magn Reson Imaging. 1993;3(5):761–9.

    Article  PubMed  Google Scholar 

  18. Blüml S, Schad LR, Scharf J, Wenz F, Knopp MV, Lorenz WJ. A comparison of magnetization prepared 3D gradientecho (MP-RAGE) sequences for imaging of intracranial lesions. Magn Reson Imaging. 1996;14(3):329–35.

    Article  PubMed  Google Scholar 

  19. Downs RK, Bashir MH, Ng CK, Heidenreich JO. Quantitative contrast ratio comparison between T1 (TSE at 1.5 T, FLAIR at 3T), magnetization prepared rapid gradient echo and subtraction imaging at 15 T and 3T. Quantitative Imaging Med Surg. 2013;3(3):141.

    Google Scholar 

  20. Schmitz BL, Aschoff AJ, Hoffmann MH, Grön G. Advantages and pitfalls in 3T MR brain imaging: a pictorial review. Am J Neuroradiol. 2005;26(9):2229–37.

    PubMed  PubMed Central  Google Scholar 

  21. Brant-Zawadzki M, Gillan GD, Nitz WR. MP RAGE: a three-dimensional, T1-weighted, gradient-echo sequence—initial experience in the brain. Radiology. 1992;182(3):769–75.

    Article  CAS  PubMed  Google Scholar 

  22. Seitz J, Held P, Strotzer M, Müller M, Völk M, Lenhart M, et al. Magnetic resonance imaging in patients diagnosed with Papilledema: a comparison of 6 different high-resolution T1-and T2 (*)-weighted 3-dimensional and 2-dimensional sequences. J Neuroimaging. 2002;12(2):164–71.

    Article  PubMed  Google Scholar 

  23. Suh CH, Jung SC, Kim KW, Pyo J. The detectability of brain metastases using contrast-enhanced spin-echo or gradient-echo images: a systematic review and meta-analysis. J Neurooncol. 2016;129(2):363–71.

    Article  PubMed  Google Scholar 

  24. Miller WP, Mantovani LF, Muzic J, Rykken JB, Gawande RS, Lund TC, et al. Intensity of MRI gadolinium enhancement in cerebral adrenoleukodystrophy: a biomarker for inflammation and predictor of outcome following transplantation in higher risk patients. Am J Neuroradiol. 2016;37(2):367–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Loes D, Fatemi A, Melhem E, Gupte N, Bezman L, Moser H, et al. Analysis of MRI patterns aids prediction of progression in X-linked adrenoleukodystrophy. Neurology. 2003;61(3):369–74.

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Hakan Cebeci was supported by a grant from The Scientific and Technical Research Council of Turkey (TUBITAK).

Author information

Authors and Affiliations

  1. Division of Neuroradiology, Department of Radiology, University of Minnesota Medical Center, 420 Delaware Street SE, Minneapolis, USA

    Hakan Cebeci, Mehmet Gencturk, Yasemin Koksel & David Nascene

  2. Department of Radiology, Faculty of Medicine, Selçuk University, Konya, Turkey

    Hakan Cebeci

Authors
  1. Hakan Cebeci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehmet Gencturk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yasemin Koksel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David Nascene
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study’s conception and design. Material preparation, data collection, and analysis were performed by HC, YK, and MG. The first draft of the manuscript was written by HC and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mehmet Gencturk.

Ethics declarations

Conflict of interest

Authors declare they have no competing interests.

Ethical approval

For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case. The study was approved by the University of Minnesota Institutional Review Board.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cebeci, H., Gencturk, M., Koksel, Y. et al. Contrast enhancement in cerebral adrenoleukodystrophy: a comparison of T1 TSE and MPRAGE sequences. Jpn J Radiol 40, 1241–1245 (2022). https://doi.org/10.1007/s11604-022-01309-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-022-01309-7

Keywords

Search

Navigation