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Does integrated shimming improve lesion detection in whole-body diffusion-weighted examinations of patients with breast cancer?

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Abstract

Purpose

To evaluate the feasibility of proposed integrated slice-by-slice shimming (iShim) for whole-body diffusion weighted imaging (WB-DWI) in comparison to conventional 3D shim in patients with breast cancer.

Materials and methods

Retrospective analysis of 116 consecutive patients (116 lesions) who underwent whole-body PET/MR using iShim (iShim group) were performed and compared with historical control of 103 patients (105 lesions) using 3D Shim (3D Shim group).

Results

As compared with dynamic contrast-enhanced (DCE) breast MRI, the apparent diffusion coefficient (ADC) value could not be determined for 15 (14%) of the 105 lesions of the 3D shim group and for 10 (9%) of the 116 lesions on iShim group. The intergroup difference failed to reach statistical significance (P = 0.1843). On the other hand, there was a significant difference in the frequencies of PET-positive and DWI-negative lesions between the 3D shim and iShim group (8.6% vs. 1.7%, respectively, P = 0.01942).

Conclusion

In regard to detectability of breast cancers by DWI, iShim may allow improved detectability as compared to conventional 3D shim.

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Author information

Authors and Affiliations

  1. Department of Radiology, Sagara Perth Avenue Clinic, 26-13 Shinyashiki-cho, Kagoshima city, 892-0838, Kagoshima, Japan

    Michiro Sasaki

  2. Department of Radiology, Sagara Hospital Affiliated Breast Center, 3-28 Tenokuchi-cho, Kagoshima city, 892-0845, Kagoshima, Japan

    Mitsuhiro Tozaki & Yoshiaki Sagara

  3. MR Research & Collaboration Dpt. Diagnostic Imaging Business Area, Siemens Healthcare K.K, Erlangen, Germany

    Katsuya Maruyama

  4. Siemens Healthcare GmbH, Erlangen, Germany

    Thomas Benkert

  5. Department of Radiology, National Defense Medical College, 3-2 Namiki, Tokorozawa city, Saitama, 359-0042, Japan

    Wakana Murakami

  6. Department of Breast Surgery, Sagara Hospital, 3-31Matsubara-cho, Kagoshima city, 892-0833, Kagoshima, Japan

    Daisuke Yotsumoto

  7. Image Inspection Department, Sagara Perth Avenue Clinic, 26-13 Shinyashiki-cho, Kagoshima city, 892-0838, Kagoshima, Japan

    Shunichi Oosako

Authors
  1. Michiro Sasaki
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  2. Mitsuhiro Tozaki
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  3. Katsuya Maruyama
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  4. Thomas Benkert
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  5. Wakana Murakami
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  6. Daisuke Yotsumoto
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  7. Shunichi Oosako
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  8. Yoshiaki Sagara
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Corresponding author

Correspondence to Michiro Sasaki.

Ethics declarations

Conflict of interest

Thomas Benkert and Katsuya Maruyama are employees of Siemens Healthcare, who provided crucial technical support with the MR sequence but were not involved in data acquisition and analysis. The authors declare that they have no conflict of interest.

Ethical approval

This retrospective study was conducted with the approval of our institutional review board. All the patients provided written informed consent for our review of their medical records and images.

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Cite this article

Sasaki, M., Tozaki, M., Maruyama, K. et al. Does integrated shimming improve lesion detection in whole-body diffusion-weighted examinations of patients with breast cancer?. Jpn J Radiol 36, 736–743 (2018). https://doi.org/10.1007/s11604-018-0781-9

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  • DOI: https://doi.org/10.1007/s11604-018-0781-9

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