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Simultaneous whole-body and breast 18F-FDG PET/MRI examinations in patients with breast cancer: a comparison of apparent diffusion coefficients and maximum standardized uptake values

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Abstract

Purpose

To compare standardized uptake value (SUV) and apparent diffusion coefficient (ADC) values acquired using a PET/MRI scanner in breast cancer patients.

Materials and methods

Whole-body PET/MRI and breast PET/MRI were performed in 108 consecutive patients. Ninety-four patients who had a total of 100 breast cancers were analyzed. SUVmax and ADCmean acquired using breast PET/MRI were compared with pathologic prognostic factors.

Results

All the lesions were visually detectable using PET and diffusion-weighted imaging (DWI) on breast PET/MRI; however, lesions were visually undetectable on whole-body DWI in 13 patients (13%) or on whole-body PET in 7 patients (7%). An analysis of ADCmean and SUVmax demonstrated a statistically significant correlation between whole-body imaging and breast imaging (rho = 0.613, p < 0.001 and rho = 0.928, p < 0.001, respectively). In a univariate analysis, SUVmax was significantly correlated with HER2 status (p < 0.001), Ki-67 (p = 0.014), tumor size (p = 0.0177), and nuclear grade (p = 0.0448). In multiple regression analysis, only tumor size (p = 0.00701) was shown to independently influence SUVmax.

Conclusion

Prone breast imaging was more sensitive than whole-body PET/MRI for detection of breast cancers. Both SUVmax and ADCmean showed limited correlation with pathologic prognostic factors.

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Author information

Authors and Affiliations

  1. Department of Radiology, Sagara Perth Avenue Clinic, 26-13 Shinyashiki-cho, Kagoshima, Kagoshima, 892-0838, Japan

    Michiro Sasaki

  2. Department of Radiology, Sagara Hospital Affiliated Breast Center, 3-28 Tenokuchi-cho, Kagoshima, Kagoshima, 892-0845, Japan

    Mitsuhiro Tozaki & Yoshiaki Sagara

  3. Department of Medical Informatics, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Kazunori Kubota

  4. Department of Radiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042, Japan

    Wakana Murakami

  5. Department of Breast Surgery, Sagara Hospital, 3-31Mtsubara-ch, Kagoshima, Kagoshima, 892-0833, Japan

    Daisuke Yotsumoto & Yasuaki Sagara

  6. Department of Pathology, Sagara Hospital, 3-31Mtsubara-cho, Kagoshima, Kagoshima, 892-0833, Japan

    Yasuyo Ohi

  7. Image Inspection Department, Sagara Perth Avenue Clinic, 26-13 Shinyashiki-cho, Kagoshima, Kagoshima, 892-0838, Japan

    Shunichi Oosako

Authors
  1. Michiro Sasaki
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  2. Mitsuhiro Tozaki
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  3. Kazunori Kubota
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  6. Yasuaki Sagara
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  7. Yasuyo Ohi
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  9. Yoshiaki Sagara
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Corresponding author

Correspondence to Michiro Sasaki.

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Sasaki, M., Tozaki, M., Kubota, K. et al. Simultaneous whole-body and breast 18F-FDG PET/MRI examinations in patients with breast cancer: a comparison of apparent diffusion coefficients and maximum standardized uptake values. Jpn J Radiol 36, 122–133 (2018). https://doi.org/10.1007/s11604-017-0707-y

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  • DOI: https://doi.org/10.1007/s11604-017-0707-y

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