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Single center experience with intralesional bleomycin sclerotherapy for lymphatic malformations

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

The purpose of our study was to evaluate the efficacy of percutaneous sclerotherapy using bleomycin in treatment of lymphatic malformations.

Methods

Between January 2009 and January 2013, ten patients with lymphatic malformations who were admitted to the interventional radiology department were included in this retrospective study. Intralesional bleomycin was administered by percutaneous injection through 21–23 Gauge needles with a dose of 1 mg/kg body weight. Patients were clinically and radiologically assessed at baseline and followed at first and third months after treatment. Response to treatment was measured visually by using photographs and by radiological images. Symptomatic improvement was also evaluated either by patients or parents.

Results

Excellent resolution was obtained visually in 80% of patients with lymphatic malformation. Significant resolution was achieved in 20% of patients. The percentage of radiographic resolution in size and the improvement in symptoms evaluated by patients or parents were similar with visual outcomes. No side effects were recorded except for fever in one patient and transient erythema in another patient.

Conclusion

Intralesional bleomycin is a safe and effective treatment for patients with lymphatic malformations.

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Author information

Authors and Affiliations

  1. Department of Radiology, Hitit University, Çorum Training and Research Hospital, Çorum, Turkey

    Hakan Yılmaz

  2. Department of Dermatology, Hitit University, Çorum Training and Research Hospital, 19200, Çorum, Turkey

    Özlem Yılmaz

  3. Department of Radiology, Ondokuz Mayıs University, 55139, Kurupelit/Samsun, Turkey

    İlkay Çamlıdağ, Ümit Belet & Hüseyin Akan

  4. Cumhuriyet M., Adnan Menderes Bulv., Zeren Sitesi, C Blok Kat:4 No:8, 55200, Atakum/Samsun, Turkey

    İlkay Çamlıdağ

Authors
  1. Hakan Yılmaz
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  2. Özlem Yılmaz
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  3. İlkay Çamlıdağ
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  4. Ümit Belet
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  5. Hüseyin Akan
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Corresponding author

Correspondence to İlkay Çamlıdağ.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical statement

The Institutional Review Board approved the study.

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Cite this article

Yılmaz, H., Yılmaz, Ö., Çamlıdağ, İ. et al. Single center experience with intralesional bleomycin sclerotherapy for lymphatic malformations. Jpn J Radiol 35, 590–596 (2017). https://doi.org/10.1007/s11604-017-0672-5

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  • DOI: https://doi.org/10.1007/s11604-017-0672-5

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