Abstract
Purpose
Q-space imaging (QSI) is a novel magnetic resonance imaging (MRI) technique that enables assessment of micro-structural changes of white matter. The acquisition time, however, is comparatively long to use for routine clinical assessment. Therefore, the present study investigated the clinically feasible b value combinations to measure the water molecular displacement probability density function (PDF) in healthy subjects.
Methods
The subjects consisted of five healthy volunteers (1 female and 4 male; 40.8 ± 13.2 years). All MRIs were examined at 1.5 T. The QSI was acquired using a single-shot echo-planar imaging and Δ/δ = 142/17 ms. The magnitude of the gradients was incremented in nine steps to reach a maximal b = 10,000 s/mm2. The total acquisition time of this original QSI was 17.4 min. The feasibility of ten alternative b value combinations with the zero-filling or curve fitting technique was assessed. The mean diffusivities (MDs), kurtosis, and zero displacement probability (ZDP) were obtained, and these results were compared in manually segmented regions of interest.
Results
There were alternative b value combinations with a 7.5-min acquisition time and with almost the same PDF.
Conclusion
A few alternative b value combinations with the curve fitting technique were found to be able to shorten the QSI acquisition for its clinical feasibility of MD and ZDP.
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Yamada received a donated course from Siemens Japan K.K. The authors declare that they have no conflict of interest except Yamada.
Appendix
Appendix
Figure 7 shows the result of the Bland-Altman plot for MD with the zero-filling and bi-exponential fitting methods. From the results of the Bland-Altman analysis of these two MD values, there was a statistical difference (P < 0.001, Student’s t test; P = 0.08, F test) between the two MDs. The results of the Bland-Altman analysis are as follows [19]: (1) there was fixed bias because the 95% confidence interval (2.67–3.04) did not include Δ = 0 [μm]; (2) there was proportional bias (t 0.05 < T). The t 0.05 was 1.99 and T was 3.12, where t 0.05 represents the percentage point of the t distribution with n-2 degrees of freedom and T represents the results of a non-correlation test by T = r × sqrt(n − 2/1 − r 2). The r was the correlation coefficient, and n was the number of samples. Therefore, these MDs are not inter-exchangeable with each other.
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Sakai, K., Yamada, K., Akazawa, K. et al. Can we shorten the q-space imaging to make it clinically feasible?. Jpn J Radiol 35, 16–24 (2017). https://doi.org/10.1007/s11604-016-0593-8
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DOI: https://doi.org/10.1007/s11604-016-0593-8