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The Latest Research Advances of Danggui Buxue Tang as an Effective Prescription for Various Diseases: A Comprehensive Review

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Abstract

Danggui Buxue Tang (DBT) is composed of Astragali Radix and Angelicae Sinensis Radix in a weight ratio of 5:1. The recipe of the decoction is simple, and DBT has been widely used in the treatment of blood deficiency syndrome for more than 800 years in China. Studies on its chemical constituents show that saponins, flavonoids, volatile oils, organic acids, and polysaccharides are the main components of DBT. Many techniques such as third-generation sequencing, PCR-denaturing gradient gel electrophoresis, and HPLC-MS have been used for the quality control of DBT. DBT has a wide range of biological activities, including blood enhancement, antagonizing diabetic nephropathy, cardiovascular protection, immunity stimulation, estrogen-like effect, and antifibrosis, among others. In this paper, we summarize the recent research advances of DBT in terms of its components, pharmacological activities, and possible mechanisms of action as well as provide suggestions for further research.

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Authors and Affiliations

  1. Central Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China

    Chen-chen Ma & Yue-hua Jiang

  2. Department of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China

    Yan Wang & Rui-rong Xu

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  1. Chen-chen Ma
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  4. Rui-rong Xu
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Correspondence to Rui-rong Xu.

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On behalf of all authors, the corresponding author states that there are no conflicts of interest.

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This work was supported by grants from the National Natural Science Foundation of China (No. 81473511 and 81974547), the Science and Technology Plan of Jinan (No. 201704073) and Natural Science Foundation of Shandong Province (No. ZR2020KH023).

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Ma, Cc., Jiang, Yh., Wang, Y. et al. The Latest Research Advances of Danggui Buxue Tang as an Effective Prescription for Various Diseases: A Comprehensive Review. CURR MED SCI 42, 913–924 (2022). https://doi.org/10.1007/s11596-022-2642-0

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  • DOI: https://doi.org/10.1007/s11596-022-2642-0

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