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Thyroid Nodules in Type 2 Diabetes Mellitus

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Summary

The present analysis aims to investigate the prevalence of thyroid nodules in type 2 diabetes mellitus (T2DM) population. We searched PubMed, EMBASE, and Web of Science from inception to the March 1, 2018. The studies were selected to estimate the prevalence of thyroid nodules in T2DM subjects and to compare the prevalence of thyroid nodules in different glucose tolerance status. The random effects model was used, and the outcome was presented as a pooled prevalence proportion with 95% confidence interval (95% CI) or a summary odds ratio (OR) with 95% CI. In the end, 9 studies met the inclusion criteria and were included in the analysis. The pooled prevalence of thyroid nodules was 60% (95% CI: 0.52, 0.68) for T2DM 2 diabetes patients, 50% (95% CI: 0.48, 0.51) for pre-diabetes, and 43% (95% CI: 0.34, 0.52) for normal glucose tolerance population. Compared with patients without diabetes, diabetes subjects are more likely to develop thyroid nodules, adjusted OR for thyroid nodule was 1.78 (95% CI: 1.25, 2.55). Insulin resistance might be involved in thyroid nodule development.

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Author notes

  1. The authors contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200092, China

    Hong-mei Zhang, Qi-wen Feng, Yi-xin Niu & Qing Su

  2. The George Institute for Global Health and Royal Prince Alfred Hospital, the University of Sydney, Sydney, NSW, 2050, Australia

    Xia Wang

Authors
  1. Hong-mei Zhang
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  2. Qi-wen Feng
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  3. Yi-xin Niu
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  4. Qing Su
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  5. Xia Wang
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Corresponding authors

Correspondence to Qing Su or Xia Wang.

Additional information

This project was supported by the National Natural Science Foundation of China (No. 81300642).

Conflict of Interest Statement

The authors declare that they have no conflict of interest.

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Zhang, Hm., Feng, Qw., Niu, Yx. et al. Thyroid Nodules in Type 2 Diabetes Mellitus. CURR MED SCI 39, 576–581 (2019). https://doi.org/10.1007/s11596-019-2076-5

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  • DOI: https://doi.org/10.1007/s11596-019-2076-5

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