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Effect of Progestin-primed Ovarian Stimulation Protocol on Outcomes of Aged Infertile Women Who Failed to Get Pregnant in the First IVF/ ICSI Cycle: A Self-controlled Study

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Summary

This study aimed to explore the outcomes of progestin-primed ovarian stimulation protocol (PPOS) in aged infertile women who failed to get pregnant in the first IVF/ICSI-ET cycles with GnRH-a long protocol. A self-controlled study was conducted to retrospectively investigate the clinical outcomes of 104 aged infertile patients who didn't get pregnant in the first IVF/ICSI-ET treatment by stimulating with GnRH-a long protocol (non-PPOS group), and underwent PPOS protocol (PPOS group) in the second cycle between January 2016 and December 2016 in the Center for Reproductive Medicine, Renmin Hospital of Wuhan University. The primary outcomes included clinical pregnancy rate of frozen-thawed embryos transfer (FET) in PPOS group, and good-quality embryo rate in both groups. The secondary outcomes were fertilization rate, egg utilization rate and cycle cancellation rate. The results showed that there were no significant differences in basal follicle stimulating hormone (bFSH), antral follicle count (AFC), duration and total dosage of gonadotropin (Gn), number of oocytes retrieved, intracytoplasmic sperm injection (ICSI) rate, fertilization rate, and cycle cancellation rate between the two groups (P>0.05). However, the oocyte utilization rate and good-quality embryo rate in PPOS group were significantly higher than those in non-PPOS group (P<0.05). By the end of April 2017,62 FET cycles were conducted in PPOS group. The clinical pregnancy rate and embryo implantation rate were 22.58% and 12.70%, respectively. In conclusion, PPOS protocol may provide better clinical outcomes by improving the oocyte utilization rate and good-quality embryo rate for aged infertile patients who failed to get pregnant in the first IVF/ICSI-ET cycles.

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Acknowledgments

We are grateful to all the staff in the Center for Reproductive Medicine, Renmin Hospital of Wuhan University for their assistance in the collection and processing of data.

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Authors and Affiliations

  1. Center for Reproductive Medicine, Renmin Hospital of Wuhan University, Hubei Clinical Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, 430060, China

    Yin-mei Chen, Qian-rong Qi, Qing-zhen Xie, Yi-fan Yang, Yi Xia & Xiao-dan Zhou

Authors
  1. Yin-mei Chen
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  2. Qian-rong Qi
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  3. Qing-zhen Xie
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  4. Yi-fan Yang
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  5. Yi Xia
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  6. Xiao-dan Zhou
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Corresponding author

Correspondence to Qing-zhen Xie.

Additional information

This work was supported by the National Natural Science Foundation of China (No.l471456), and Guidance Foundation of Renmin Hospital of Wuhan University (No. RMYD2018Zl3).

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Chen, Ym., Qi, Qr., Xie, Qz. et al. Effect of Progestin-primed Ovarian Stimulation Protocol on Outcomes of Aged Infertile Women Who Failed to Get Pregnant in the First IVF/ ICSI Cycle: A Self-controlled Study. CURR MED SCI 38, 513–518 (2018). https://doi.org/10.1007/s11596-018-1908-z

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  • DOI: https://doi.org/10.1007/s11596-018-1908-z

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