Abstract
This study evaluated the myocardial strain and aortic elasticity in patients with bicuspid aortic valve (BAV) and then investigated the relation between them. Thirty-nine patients (30 males; mean age 44±19 years; range 6 to 75 years) with BAV were recruited as BAV group, and 29 age- and sex-matched healthy controls (21 males; mean age 42±11 years; range 20 to 71 years) served as control group. Aortic strain, distensibility and stiffness index were derived using M-mode echocardiography. Left ventricular global myocardial strain was acquired with speckle-tracking echocardiography. Correlation between aortic elasticity and myocardial strain was also analyzed. The results showed that aortic stiffness was higher (17.5±14.0 vs. 5.3±2.7, P<0.001), and aortic strain (4.9±4.7 vs. 11.0±4.1, P<0.001) and distensibility (1.8±2.1 vs. 3.7±1.6, P<0.001) were lower significantly in BAV group than in control group. Global circumferential strain (–19.1±4.2 vs.–22.5±3.7, P<0.001), radial stain (29.8±14.9 vs. 38.0±8.8, P<0.001) and longitudinal stain (–18.4±3.4 vs.–20.8±3.5, P<0.001) were significantly lower in BAV group than in control group. There was weak association between aortic elasticity and myocardial strain. These findings indicated BAV patients manifest reduced myocardial strain which had weak relationship with aortic elastic lesion.
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Prakash SK, Bosse Y, Muehlschlegel JD, et al. A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium). J Am Coll Cardiol, 2014,64(8):832–839
Siu SC, Silversides CK. Bicuspid aortic valve disease. J Am Coll Cardiol, 2010,55(25):2789–2800
Michelena HI, Prakash SK, Della Corte A, et al. Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon). Circulation, 2014,129(25):2691–2704
Wang Y, Wu B, Dong L, et al. Circulating matrix metalloproteinase patterns in association with aortic dilatation in bicuspid aortic valve patients with isolated severe aortic stenosis. Heart Vessels, 2016,31(2):189–197
Tzemos N, Lyseggen E, Silversides C, et al. Endothelial function, carotid-femoral stiffness, and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aorta. J Am Coll Cardiol, 2010,55(7):660–668
Rabkin SW. Differential expression of MMP-2, MMP-9 and TIMP proteins in thoracic aortic aneurysm— comparison with and without bicuspid aortic valve: a meta-analysis. Vasa, 2014,43(6):433–442
Oulego-Erroz I, Alonso-Quintela P, Mora-Matilla M, et al. Ascending aorta elasticity in children with isolated bicuspid aortic valve. Int J Cardiol, 2013,168(2):1143–1146
Pees C, Michel-Behnke I. Morphology of the bicuspid aortic valve and elasticity of the adjacent aorta in children. Am J Cardiol, 2012,110(9):1354–1360
Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr, 2015,28 (1):1–39
Quinones MA, Otto CM, Stoddard M, et al. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr, 2002,15(2):167–184
Zoghbi WA, Enriquez-Sarano M, Foster E, et al. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr, 2003,16(7):777–802
Wang C, Deng YB, Zhu Y, et al. Evaluation of subtle myocardial noncompaction by contrast echocardiography in patients with hypertrophic cardiomyopathy and its relationship with regional ventricular systolic dysfunction. J Ultrasound Med, 2012,31(10):1551–1557
Santarpia G, Scognamiglio G, Di Salvo G, et al. Aortic and left ventricular remodeling in patients with bicuspid aortic valve without significant valvular dysfunction: a prospective study. Int J Cardiol, 2012,158(3):347–352
Nistri S, Grande-Allen J, Noale M, et al. Aortic elasticity and size in bicuspid aortic valve syndrome. Eur Heart J, 2008,29(4):472–479
Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest, 1975,56(1):56–64
Grotenhuis HB, Ottenkamp J, Westenberg JJ, et al. Reduced aortic elasticity and dilatation are associated with aortic regurgitation and left ventricular hypertrophy in nonstenotic bicuspid aortic valve patients. J Am Coll Cardiol, 2007,49(15):1660–1665
Aicher D, Urbich C, Zeiher A, et al. Endothelial nitric oxide synthase in bicuspid aortic valve disease. Ann Thorac Surg, 2007,83(4):1290–1294
Bloch W, Fleischmann BK, Lorke DE, et al. Nitric oxide synthase expression and role during cardiomyogenesis. Cardiovasc Res, 1999,43(3):675–684
Bloch W, Addicks K, Hescheler J, et al. Nitric oxide synthase expression and function in embryonic and adult cardiomyocytes. Microsc Res Tech, 2001,55(4):259–269
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This project was supported by the National Natural Science Foundation of China (No. 81571695).
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Li, Y., Deng, Yb., Bi, Xj. et al. Evaluation of myocardial strain and aortic elasticity in patients with bicuspid aortic valve. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 36, 747–751 (2016). https://doi.org/10.1007/s11596-016-1656-x
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DOI: https://doi.org/10.1007/s11596-016-1656-x