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Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer

  • Biomaterial
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Journal of Wuhan University of Technology-Mater. Sci. Ed. Aims and scope Submit manuscript

Abstract

A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR- mAb were identifed. The in vitro release studies revealed that this drug delivery system was acid-sensitive, and the self-assembled nanoparticles which were spherical. The in vitro results indicated that the dual-receptor targeting nanoparticles could be faster internalized into the Cal-27 cells via receptor-mediated endocytosis, which exhibited better antitumor activity than the one-receptor nanoparticles. The experimental results clearly reveal that CMCS-hyd-CUR-EGFR mAb provides a novel way for drug delivery in oral cancer treatment.

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Authors and Affiliations

  1. Department of Phamaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China

    Shanshan Wu  (吴珊珊), Fuliang Xiong, Xueqiong Zhang & Mingxiu Tang

  2. Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan, 430070, China

    Tong Qiu

  3. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430072, China

    Xiaojing Ye

  4. Department of stomatology, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, China

    Zhijun Chen  (陈芷筠)

  5. Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan, 430072, China

    Gang Zhou  (周刚)

Authors
  1. Shanshan Wu  (吴珊珊)
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  2. Fuliang Xiong
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  3. Xueqiong Zhang
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  4. Tong Qiu
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  5. Mingxiu Tang
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  6. Xiaojing Ye
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  7. Zhijun Chen  (陈芷筠)
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  8. Gang Zhou  (周刚)
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Corresponding authors

Correspondence to Zhijun Chen  (陈芷筠) or Gang Zhou  (周刚).

Additional information

Funded by the National Natural Science Foundation of China (Nos.81771080 and 8131147), the Opening Project of Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients (No. HLPAI 2014006) and the Health Commission of Hubei Province Scientific Research Project (No. WJ2019H275)

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Wu, S., Xiong, F., Zhang, X. et al. Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 34, 1495–1504 (2019). https://doi.org/10.1007/s11595-019-2218-4

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  • DOI: https://doi.org/10.1007/s11595-019-2218-4

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