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Enhance the Design and Performance Analysis of a Highly Sensitive Twin-Core PCF SPR Biosensor with Gold Plating for the Early Detection of Cancer Cells

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Abstract

Surface plasmon resonance (SPR) technique is an excellent method for providing optical and label-free detection of target bioanalytes. In this research, we suggest a novel SPR biosensor based on a hybrid TiO2/Au layer that offers improved sensitivity and detection capabilities for cancer cells. The biosensor is based on a hybrid TiO2/Au layer, which enhances the performance of the sensor by making the gold coating and fiber more adherent to each other. Our prototype’s fiber is strategically drilled with circular air holes, which enhances the sensor’s performance. To validate the proposed design, numerical analysis was performed using the finite element model (FEM) technique of COMSOL Multiphysics Simulation tool. The refractive index changes of cancer cells are discovered using the wavelength-interrogation and amplitude-interrogation approaches. Based on the numerical findings of spectrum interrogation and amplitude techniques, we found that the greatest sensitivity of this biosensor is 4078.43 nm/RIU for Hela using spectral interrogation and 4285.71 1/RIU for MCF7 cell utilizing amplitude-interrogation techniques. This sensor also displays the highest resolution for basal cells of 4.0 × 10−5 RIU.

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Data Availability Statement

The manuscript contains all the data that was produced or analyzed during the study, ensuring its availability.

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Acknowledgements

The authors gratefully acknowledge that the COMSOL 5.4 Multiphysics (commercial package) software and further help were provided by the MEMS Lab at the National Institute of Technology Nagaland, Chumukedima-797103.

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Authors and Affiliations

  1. Department of Electronics and Instrumentation Engineering, National Institute of Technology, Nagaland, Dimapur-797103, India

    Khalid Mohd Ibrahimi, R. Kumar & Writtick Pakhira

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  1. Khalid Mohd Ibrahimi
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  2. R. Kumar
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  3. Writtick Pakhira
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Contributions

Khalid Mohd Ibrahimi made significant contributions to the research’s idea and design, analysis and investigation of the proposed design, validation of the simulation software, and writing original draft. R. Kumar made significant contributions to the supervision, investigation, reviewing, and editing of the final manuscript. Writtick Pakhira made significant contributions in preparation of the figures and tables.

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Correspondence to Khalid Mohd Ibrahimi.

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Ibrahimi, K.M., Kumar, R. & Pakhira, W. Enhance the Design and Performance Analysis of a Highly Sensitive Twin-Core PCF SPR Biosensor with Gold Plating for the Early Detection of Cancer Cells. Plasmonics 18, 995–1006 (2023). https://doi.org/10.1007/s11468-023-01825-w

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