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Design and analysis of a dual-core PCF biosensor based on SPR for cancerous cells detection

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Abstract

The present investigation examines a novel dual-core photonic crystal fiber (PCF) for early cancer cell detection that is based on a surface plasmon resonance (SPR) biosensor. The PCF is coated with Au/TiO2 layers to boost sensor effectiveness by enhancing the adhesion between the fiber and gold layers. The sensor was simulated and analyzed using the COMSOL Multiphysics software, which is based on the finite element method (FEM). Spectral and amplitude interrogations were used to explore the RI fluctuations of various cancer cells. The observed RI values varied within the range of 1.36–1.401. The biosensor’s highest sensitivity was found to be 11,429 nm/RIU for MCF-7 cells using spectral interrogation and 1251.18 RIU−1 for MDA-MB231 cells utilizing amplitude interrogation techniques. Additionally, the sensor shows the maximum resolution for basal cells, which is 8.75 × 10−6 RIU.

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Authors and Affiliations

  1. Department of Physics, College of Science, Al-Nahrain University, P.O. Box 64055, Jadriya, Baghdad, Iraq

    Mohammed F. Majeed

  2. Remote Sensing Unit, Baghdad University, Jadriya, Baghdad, Iraq

    Mohammed F. Majeed

  3. Department of Laser and Optoelectronics Engineering, College of Engineering, Al-Nahrain University, P.O. Box 64044, Jadriya, Baghdad, Iraq

    Ahmad K. Ahmad

Authors
  1. Mohammed F. Majeed
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  2. Ahmad K. Ahmad
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Contributions

MFM and AK: Conceptualization, Methodology MFM: Data curation, writing, original draft preparation. MFM: visualization, investigation. AKA: supervision. MFM: Software, Validation. AKA and MFM: writing, reviewing, and editing.

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Correspondence to Mohammed F. Majeed or Ahmad K. Ahmad.

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Majeed, M.F., Ahmad, A.K. Design and analysis of a dual-core PCF biosensor based on SPR for cancerous cells detection. Opt Quant Electron 56, 1030 (2024). https://doi.org/10.1007/s11082-024-06566-6

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