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Identifying Metal Nanoparticle Size Effect on Sensing Common Human Plasma Protein by Counting the Sensitivity of Optical Absorption Spectra Damping

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Abstract

Colloidal nanoparticles (NPs) interact with biological fluids such as human plasma to form a protein coating (corona) on the surface of NPs (NP-protein complex). However, the impact of size and type of NPs on binding of the hard corona to the surface of NPs as well as damping of their optical spectra has not been systematically explored. To elucidate the interaction between biological environment (human plasma) and NPs, a photophysical measurement was conducted to quantify the interaction of two different types of NPs (gold (Au) and silver (Ag)) with common human plasma proteins. The colloidal AuNPs and AgNPs were electrostatically stabilized and varied in diameter from 10 to 80 nm in the presence of common human plasma. The sizes of the NPs were determined using transmission electron microscopy (TEM). Optical absorption spectra were obtained for the complexes. Dynamic light scattering (DLS) measurement and zeta potential were used to characterize the sizes, hydrodynamic diameters, and surface charges of the protein-NPs complexes. Protein separation was performed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to isolate and identify the protein bands. The absorption of proteins to the NPs was found to be strongly dependent on the size and type of NPs. The distance between surface of NPs by absorbed protein bound to the NPs gradually increased with size of NPs, particularly for AgNPs with primary diameter of < 50 nm. The chi-square test proved that AgNPs are a good candidate in sensing the protein complex in human plasma compared with AuNPs mainly for the AgNPs with diameter sized 50 nm.

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Funding

The authors would like to thank Universiti Sains Malaysia for funding this research work through its Transdisciplinary Research Grant Scheme (203.PFIZIK.6763003).

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Authors and Affiliations

  1. School of Physics, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia

    B. Mehrdel, A. Abdul Aziz, P. Moradi Khaniabadi, M. Subhi Jameel & M. Ali Dheyab

  2. Nano-Biotechnology Research and Innovation Lab (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia

    N. Othman & A. Abdul Aziz

  3. Computational Optics Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam

    I. S. Amiri

  4. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam

    I. S. Amiri

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  1. B. Mehrdel
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  2. N. Othman
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  4. P. Moradi Khaniabadi
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  5. M. Subhi Jameel
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Correspondence to B. Mehrdel or A. Abdul Aziz.

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Mehrdel, B., Othman, N., Aziz, A.A. et al. Identifying Metal Nanoparticle Size Effect on Sensing Common Human Plasma Protein by Counting the Sensitivity of Optical Absorption Spectra Damping. Plasmonics 15, 123–133 (2020). https://doi.org/10.1007/s11468-019-01007-7

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  • DOI: https://doi.org/10.1007/s11468-019-01007-7

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