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Emissive metallacages for biomedical applications

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Abstract

Owing to their appealing three-dimensional structures and tunable photophysical properties, emissive metallacages have been widely applied in recognition and sensing, adsorption and separation, catalysis, etc. Recently, the application of emissive metallacages in biomedical fields has emerged as a hot research topic, because multiple biological functionalities can be facilely integrated into metallacage-based platforms to deliver different functions. In this review, the applications of emissive metallacages in bio-imaging, delivery and cancer theranostics are systematically summarized. The dilemmas and challenges of metallacage-based biomedical materials are also raised at the end of this review. We hope this review would provide some guidance for the construction of novel emissive metallacages with biological functions, and further advance the development of emissive metallacages as biomedical materials.

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References

  1. Inokuma Y, Kawano M, Fujita M. Nat Chem, 2011, 3: 349–358

    Article  CAS  PubMed  Google Scholar 

  2. Cook TR, Stang PJ. Chem Rev, 2015, 115: 7001–7045

    Article  CAS  PubMed  Google Scholar 

  3. Wang W, Wang YX, Yang HB. Chem Soc Rev, 2016, 45: 2656–2693

    Article  CAS  PubMed  Google Scholar 

  4. Brown CJ, Toste FD, Bergman RG, Raymond KN. Chem Rev, 2015, 115: 3012–3035

    Article  CAS  PubMed  Google Scholar 

  5. Clever GH, Punt P. Acc Chem Res, 2017, 50: 2233–2243

    Article  CAS  PubMed  Google Scholar 

  6. Chakraborty S, Newkome GR. Chem Soc Rev, 2018, 47: 3991–4016

    Article  CAS  PubMed  Google Scholar 

  7. Zhang D, Ronson TK, Nitschke JR. Acc Chem Res, 2018, 51: 2423–2436

    Article  CAS  PubMed  Google Scholar 

  8. Rizzuto FJ, von Krbek LKS, Nitschke JR. Nat Rev Chem, 2019, 3: 204–222

    Article  Google Scholar 

  9. Pan M, Wu K, Zhang JH, Su CY. Coord Chem Rev, 2019, 378: 333–349

    Article  CAS  Google Scholar 

  10. Sun Y, Chen C, Liu J, Stang PJ. Chem Soc Rev, 2020, 49: 3889–3919

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Jin Y, Zhang Q, Zhang Y, Duan C. Chem Soc Rev, 2020, 49: 5561–5600

    Article  CAS  PubMed  Google Scholar 

  12. Sun Y, Stang PJ. Aggregate, 2021, 2: e94

    Article  CAS  Google Scholar 

  13. Sheng TP, Wei Y, Jampani P, Li C, Dai FR, Huang S, Wang Z, Chen ZN. Sci China Chem, 2023, 66: 1714–1721

    Article  CAS  Google Scholar 

  14. Gao Z, Han Y, Gao Z, Wang F. Acc Chem Res, 2018, 51: 2719–2729

    Article  CAS  PubMed  Google Scholar 

  15. Sawada T, Saito A, Tamiya K, Shimokawa K, Hisada Y, Fujita M. Nat Commun, 2019, 10: 921

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ward MD, Hunter CA, Williams NH. Acc Chem Res, 2018, 51: 2073–2082

    Article  CAS  PubMed  Google Scholar 

  17. Preston D, Sutton JJ, Gordon KC, Crowley JD. Angew Chem Int Ed, 2018, 57: 8659–8663

    Article  CAS  Google Scholar 

  18. Li SC, Cai LX, Zhou LP, Guo F, Sun QF. Sci China Chem, 2019, 62: 713–718

    Article  CAS  Google Scholar 

  19. Tamura Y, Takezawa H, Fujita M. J Am Chem Soc, 2020, 142: 5504–5508

    Article  CAS  PubMed  Google Scholar 

  20. Hou Y, Zhang Z, Lu S, Yuan J, Zhu Q, Chen WP, Ling S, Li X, Zheng YZ, Zhu K, Zhang M. J Am Chem Soc, 2020, 142: 18763–18768

    Article  CAS  PubMed  Google Scholar 

  21. Zhao J, Zhou Z, Li G, Stang PJ, Yan X. Natl Sci Rev, 2021, 8: nwab045

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Hou Y, Zhang Z, Ma L, Shi R, Ling S, Li X, He G, Zhang M. CCS Chem, 2022, 4: 2604–2611

    Article  CAS  Google Scholar 

  23. Neelakandan PP, Jiménez A, Nitschke JR. Chem Sci, 2014, 5: 908–915

    Article  CAS  Google Scholar 

  24. Yamashina M, Sartin MM, Sei Y, Akita M, Takeuchi S, Tahara T, Yoshizawa M. J Am Chem Soc, 2015, 137: 9266–9269

    Article  CAS  PubMed  Google Scholar 

  25. Yan X, Cook TR, Wang P, Huang F, Stang PJ. Nat Chem, 2015, 7: 342–348

    Article  CAS  PubMed  Google Scholar 

  26. Chen S, Li K, Zhao F, Zhang L, Pan M, Fan YZ, Guo J, Shi J, Su CY. Nat Commun, 2016, 7: 13169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Yan X, Wang M, Cook TR, Zhang M, Saha ML, Zhou Z, Li X, Huang F, Stang PJ. J Am Chem Soc, 2016, 138: 4580–4588

    Article  CAS  PubMed  Google Scholar 

  28. Feng HT, Yuan YX, Xiong JB, Zheng YS, Tang BZ. Chem Soc Rev, 2018, 47: 7452–7476

    Article  CAS  PubMed  Google Scholar 

  29. Zhang T, Zhang GL, Yan QQ, Zhou LP, Cai LX, Guo XQ, Sun QF. Inorg Chem, 2018, 57: 3596–3601

    Article  CAS  PubMed  Google Scholar 

  30. Sun Y, Yao Y, Wang H, Fu W, Chen C, Saha ML, Zhang M, Datta S, Zhou Z, Yu H, Li X, Stang PJ. J Am Chem Soc, 2018, 140: 12819–12828

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Yan X, Wei P, Liu Y, Wang M, Chen C, Zhao J, Li G, Saha ML, Zhou Z, An Z, Li X, Stang PJ. J Am Chem Soc, 2019, 141: 9673–9679

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Li M, Jiang S, Zhang Z, Hao XQ, Jiang X, Yu H, Wang P, Xu B, Wang M, Tian W. CCS Chem, 2020, 2: 337–348

    Article  CAS  Google Scholar 

  33. Liu H, Guo C, Zhang Z, Mu C, Feng Q, Zhang M. Chem Eur J, 2023, 29: e202203926

    Article  CAS  PubMed  Google Scholar 

  34. Feng Q, Li N, Zhang Z, Gao K, Wang K, Ling S, Yuan H, Zhang Y, Zhang M. Chin Chem Lett, 2023, 108439

  35. Mu C, Hou Y, Zhang Z, Liu H, Guo C, Zhang M. Fundamental Res, 2023, doi: https://doi.org/10.1016/j.fmre.2023.03.012

  36. Yang Z, Wang Y, Liu X, Vanderlinden RT, Ni R, Li X, Stang PJ. J Am Chem Soc, 2020, 142: 13689–13694

    Article  CAS  PubMed  Google Scholar 

  37. Li Y, Yu JG, Ma LL, Li M, An YY, Han YF. Sci China Chem, 2021, 64: 701–718

    Article  CAS  Google Scholar 

  38. Li Y, Rajasree SS, Lee GY, Yu J, Tang JH, Ni R, Li G, Houk KN, Deria P, Stang PJ. J Am Chem Soc, 2021, 143: 2908–2919

    Article  CAS  PubMed  Google Scholar 

  39. Guo Z, Li G, Wang H, Zhao J, Liu Y, Tan H, Li X, Stang PJ, Yan X. J Am Chem Soc, 2021, 143: 9215–9221

    Article  CAS  PubMed  Google Scholar 

  40. Mu C, Zhang Z, Hou Y, Liu H, Ma L, Li X, Ling S, He G, Zhang M. Angew Chem Int Ed, 2021, 60: 12293–12297

    Article  CAS  Google Scholar 

  41. Liu H, Zhang Z, Mu C, Ma L, Yuan H, Ling S, Wang H, Li X, Zhang M. Angew Chem Int Ed, 2022, 61: e202207289

    Article  CAS  Google Scholar 

  42. Zhang Z, Ma L, Fang F, Hou Y, Lu C, Mu C, Zhang Y, Liu H, Gao K, Wang M, Zhang Z, Li X, Zhang M. JACS Au, 2022, 2: 1479–1487

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Slater AG, Cooper AI. Science, 2015, 348: 988

    Article  CAS  Google Scholar 

  44. Vardhan H, Yusubov M, Verpoort F. Coord Chem Rev, 2016, 306: 171–194

    Article  CAS  Google Scholar 

  45. Saha ML, Yan X, Stang PJ. Acc Chem Res, 2016, 49: 2527–2539

    Article  CAS  PubMed  Google Scholar 

  46. Liu CL, Zhang RL, Lin CS, Zhou LP, Cai LX, Kong JT, Yang SQ, Han KL, Sun QF. J Am Chem Soc, 2017, 139: 12474–12479

    Article  CAS  PubMed  Google Scholar 

  47. Zhang M, Saha ML, Wang M, Zhou Z, Song B, Lu C, Yan X, Li X, Huang F, Yin S, Stang PJ. J Am Chem Soc, 2017, 139: 5067–5074

    Article  CAS  PubMed  Google Scholar 

  48. Zhang Z, Zhao Z, Wu L, Lu S, Ling S, Li G, Xu L, Ma L, Hou Y, Wang X, Li X, He G, Wang K, Zou B, Zhang M. J Am Chem Soc, 2020, 142: 2592–2600

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Dong J, Wee V, Peh SB, Zhao D. Angew Chem Int Ed, 2021, 60: 16279–16292

    Article  CAS  Google Scholar 

  50. Luo D, Wu LX, Zhang Y, Huang YL, Chen XL, Zhou XP, Li D. Sci China Chem, 2022, 65: 1105–1111

    Article  CAS  Google Scholar 

  51. Cook TR, Vajpayee V, Lee MH, Stang PJ, Chi KW. Acc Chem Res, 2013, 46: 2464–2474

    Article  CAS  PubMed  Google Scholar 

  52. Ahmad N, Younus HA, Chughtai AH, Verpoort F. Chem Soc Rev, 2015, 44: 9–25

    Article  CAS  PubMed  Google Scholar 

  53. Sepehrpour H, Fu W, Sun Y, Stang PJ. J Am Chem Soc, 2019, 141: 14005–14020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Tapia L, Alfonso I, Solà J. Org Biomol Chem, 2021, 19: 9527–9540

    Article  CAS  PubMed  Google Scholar 

  55. Tuo W, Xu Y, Fan Y, Li J, Qiu M, Xiong X, Li X, Sun Y. Coord Chem Rev, 2021, 443: 214017

    Article  CAS  Google Scholar 

  56. Wang C, Wang W, Tan J, Zhang X, Yuan D, Zhou HC. Coord Chem Rev, 2021, 438: 213752

    Article  CAS  Google Scholar 

  57. Xu J, Wang J, Ye J, Jiao J, Liu Z, Zhao C, Li B, Fu Y. Adv Sci, 2021, 8: 2101101

    Article  CAS  Google Scholar 

  58. Dou WT, Yang CY, Hu LR, Song B, Jin T, Jia PP, Ji X, Zheng F, Yang HB, Xu L. ACS Mater Lett, 2023, 5: 1061–1082

    Article  CAS  Google Scholar 

  59. Li G, Zhou Z, Yuan C, Guo Z, Liu Y, Zhao D, Liu K, Zhao J, Tan H, Yan X. Angew Chem Int Ed, 2020, 59: 10013–10017

    Article  CAS  Google Scholar 

  60. Li Y, Yang T, Li N, Bai S, Li X, Ma LL, Wang K, Zhang Y, Han YF. CCS Chem, 2022, 4: 732–743

    Article  CAS  Google Scholar 

  61. Lu C, Zhang M, Tang D, Yan X, Zhang ZY, Zhou Z, Song B, Wang H, Li X, Yin S, Sepehrpour H, Stang PJ. J Am Chem Soc, 2018, 140: 7674–7680

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Zhang Z, Zhao Z, Hou Y, Wang H, Li X, He G, Zhang M. Angew Chem Int Ed, 2019, 58: 8862–8866

    Article  CAS  Google Scholar 

  63. Vij V, Bhalla V, Kumar M. Chem Rev, 2016, 116: 9565–9627

    Article  CAS  PubMed  Google Scholar 

  64. Dong J, Pan Y, Wang H, Yang K, Liu L, Qiao Z, Yuan YD, Peh SB, Zhang J, Shi L, Liang H, Han Y, Li X, Jiang J, Liu B, Zhao D. Angew Chem Int Ed, 2020, 59: 10151–10159

    Article  CAS  Google Scholar 

  65. Hagiwara K, Akita M, Yoshizawa M. Chem Sci, 2015, 6: 259–263

    Article  CAS  PubMed  Google Scholar 

  66. Okazawa Y, Kondo K, Akita M, Yoshizawa M. J Am Chem Soc, 2015, 137: 98–101

    Article  CAS  PubMed  Google Scholar 

  67. Roy B, Ghosh AK, Srivastava S, D’Silva P, Mukherjee PS. J Am Chem Soc, 2015, 137: 11916–11919

    Article  CAS  PubMed  Google Scholar 

  68. Bhat IA, Jain R, Siddiqui MM, Saini DK, Mukherjee PS. Inorg Chem, 2017, 56: 5352–5360

    Article  CAS  PubMed  Google Scholar 

  69. Cao L, Hettiarachchi G, Briken V, Isaacs L. Angew Chem Int Ed, 2013, 52: 12033–12037

    Article  CAS  Google Scholar 

  70. Yu HJ, Zhou Q, Dai X, Shen FF, Zhang YM, Xu X, Liu Y. J Am Chem Soc, 2021, 143: 13887–13894

    Article  CAS  PubMed  Google Scholar 

  71. Pun SH, Davis ME. Bioconjugate Chem, 2002, 13: 630–639

    Article  CAS  Google Scholar 

  72. Heidel JD, Yu Z, Liu YC, Rele SM, Liang Y, Zeidan RK, Kornbrust DJ, Davis ME. Proc Natl Acad Sci USA, 2007, 104: 5715–5721

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Davis ME, Zuckerman JE, Choi CHJ, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. Nature, 2010, 464: 1067–1070

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Lewis JEM, Gavey EL, Cameron SA, Crowley JD. Chem Sci, 2012, 3: 778–784

    Article  CAS  Google Scholar 

  75. Samanta SK, Moncelet D, Vinciguerra B, Briken V, Isaacs L. Helv Chim Acta, 2018, 101: e1800057

    Article  PubMed  PubMed Central  Google Scholar 

  76. Feng Q, Yang T, Ma L, Li X, Yuan H, Zhang M, Zhang Y, Fan L. ACS Appl Mater Interfaces, 2022, 14: 38594–38603

    Article  CAS  PubMed  Google Scholar 

  77. Howlader P, Mondal B, Purba PC, Zangrando E, Mukherjee PS. J Am Chem Soc, 2018, 140: 7952–7960

    Article  CAS  PubMed  Google Scholar 

  78. Saha R, Devaraj A, Bhattacharyya S, Das S, Zangrando E, Mukherjee PS. J Am Chem Soc, 2019, 141: 8638–8645

    Article  CAS  PubMed  Google Scholar 

  79. Purba PC, Maity M, Bhattacharyya S, Mukherjee PS. Angew Chem Int Ed, 2021, 60: 14109–14116

    Article  CAS  Google Scholar 

  80. Zheng YR, Suntharalingam K, Johnstone TC, Lippard SJ. Chem Sci, 2015, 6: 1189–1193

    Article  CAS  PubMed  Google Scholar 

  81. Judge N, Wang L, Ho YYL, Wang Y. Macromol Res, 2018, 16: 1074–1084

    Article  Google Scholar 

  82. Lewis JEM, John McAdam C, Gardiner MG, Crowley JD. Chem Commun, 2013, 49: 3398–3400

    Article  CAS  Google Scholar 

  83. Lewis JEM, Elliott ABS, McAdam CJ, Gordon KC, Crowley JD. Chem Sci, 2014, 5: 1833–1843

    Article  CAS  Google Scholar 

  84. Elliott ABS, Lewis JEM, van der Salm H, McAdam CJ, Crowley JD, Gordon KC. Inorg Chem, 2016, 55: 3440–3447

    Article  CAS  PubMed  Google Scholar 

  85. van Hilst QVC, Lagesse NR, Preston D, Crowley JD. Dalton Trans, 2018, 47: 997–1002

    Article  CAS  PubMed  Google Scholar 

  86. Aikman B, Bonsignore R, Woods B, Doellerer D, Scotti R, Schmidt C, Heidecker AA, Pöthig A, Sayers EJ, Jones AT, Casini A. Dalton Trans, 2022, 51: 7476–7490

    Article  CAS  PubMed  Google Scholar 

  87. Samanta SK, Moncelet D, Briken V, Isaacs L. J Am Chem Soc, 2016, 138: 14488–14496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Samanta SK, Quigley J, Vinciguerra B, Briken V, Isaacs L. J Am Chem Soc, 2017, 139: 9066–9074

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Castano AP, Mroz P, Hamblin MR. Nat Rev Cancer, 2006, 6: 535–545

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Ethirajan M, Chen Y, Joshi P, Pandey RK. Chem Soc Rev, 2011, 40: 340–362

    Article  CAS  PubMed  Google Scholar 

  91. Sun Z, Zhang LP, Wu F, Zhao Y. Adv Funct Mater, 2017, 27: 1704079

    Article  Google Scholar 

  92. Hu W, He T, Zhao H, Tao H, Chen R, Jin L, Li J, Fan Q, Huang W, Baev A, Prasad PN. Angew Chem Int Ed, 2019, 58: 11105–11111

    Article  CAS  Google Scholar 

  93. Therrien B, Süss-Fink G, Govindaswamy P, Renfrew A, Dyson P. Angew Chem Int Ed, 2008, 47: 3773–3776

    Article  CAS  Google Scholar 

  94. Schmitt F, Freudenreich J, Barry NPE, Juillerat-Jeanneret L, Süss-Fink G, Therrien B. J Am Chem Soc, 2012, 134: 754–757

    Article  CAS  PubMed  Google Scholar 

  95. Galstyan A. Chem Eur J, 2021, 27: 1903–1920

    Article  CAS  PubMed  Google Scholar 

  96. Zheng BD, Ye J, Zhang XQ, Zhang N, Xiao MT. Coord Chem Rev, 2021, 447: 214155

    Article  CAS  Google Scholar 

  97. Abdul Rinshad V, Sahoo J, Venkateswarulu M, Hickey N, De M, Mukherjee P S. Angew Chem Int Ed, 2023, 62: e202218226

    Article  CAS  Google Scholar 

  98. Zhang Z, Shen W, Ling J, Yan Y, Hu J, Cheng Y. Nat Commun, 2018, 9: 1377

    Article  PubMed  PubMed Central  Google Scholar 

  99. Liu J, Luo T, Xue Y, Mao L, Stang PJ, Wang M. Angew Chem Int Ed, 2021, 60: 5429–5435

    Article  CAS  Google Scholar 

  100. Liu J, Sheng J, Shao L, Zheng Q, Li W, Chen X, Mao L, Wang M. Angew Chem Int Ed, 2021, 60: 26740–26746

    Article  CAS  Google Scholar 

  101. Ma L, Yang T, Zhang Z, Yin S, Song Z, Wen S, Chu D, Zhang Y, Zhang M. Chin Chem Lett, 2019, 30: 2459–2463

    Google Scholar 

  102. Samanta SK, Isaacs L. Coord Chem Rev, 2020, 410: 213181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Ahmedova A. Front Chem, 2018, 6: 620

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Vajpayee V, Yang YJ, Kang SC, Kim H, Kim IS, Wang M, Stang PJ, Chi KW. Chem Commun, 2011, 47: 5184–5186

    Article  CAS  Google Scholar 

  105. Grishagin IV, Pollock JB, Kushal S, Cook TR, Stang PJ, Olenyuk BZ. Proc Natl Acad Sci USA, 2014, 111: 18448–18453

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Yu G, Cook TR, Li Y, Yan X, Wu D, Shao L, Shen J, Tang G, Huang F, Chen X, Stang PJ. Proc Natl Acad Sci USA, 2016, 113: 13720–13725

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Wang X, Su Q, Zhang Z, Yang J, Zhang Y, Zhang M. Chem Commun, 2020, 56: 8460–8463

    Article  CAS  Google Scholar 

  108. Li C, Jia PP, Xu YL, Ding F, Yang WC, Sun Y, Li XP, Yin GQ, Xu L, Yang GF. Sci China Chem, 2021, 64: 134–142

    Article  CAS  Google Scholar 

  109. Zuo J, Gao X, Xiao J, Cheng Y. Chin Chem Lett, 2023, 34: 107827

    Article  CAS  Google Scholar 

  110. Yu G, Yu S, Saha ML, Zhou J, Cook TR, Yung BC, Chen J, Mao Z, Zhang F, Zhou Z, Liu Y, Shao L, Wang S, Gao C, Huang F, Stang PJ, Chen X. Nat Commun, 2018, 9: 4335

    Article  PubMed  PubMed Central  Google Scholar 

  111. Liu J, Chen Q, Zhu W, Yi X, Yang Y, Dong Z, Liu Z. Adv Funct Mater, 2017, 27: 1605926

    Article  Google Scholar 

  112. Jia Q, Ge J, Liu W, Zheng X, Chen S, Wen Y, Zhang H, Wang P. Adv Mater, 2018, 30: 1706090

    Article  Google Scholar 

  113. Feng L, Dong Z, Tao D, Zhang Y, Liu Z. Natl Sci Rev, 2018, 5: 269–286

    Article  CAS  Google Scholar 

  114. Sun S, Chen Q, Tang Z, Liu C, Li Z, Wu A, Lin H. Angew Chem Int Ed, 2020, 59: 21041–21048

    Article  CAS  Google Scholar 

  115. Zhu H, Li Q, Shi B, Ge F, Liu Y, Mao Z, Zhu H, Wang S, Yu G, Huang F, Stang PJ. Angew Chem Int Ed, 2020, 59: 20208–20214

    Article  CAS  Google Scholar 

  116. Yu G, Zhu B, Shao L, Zhou J, Saha ML, Shi B, Zhang Z, Hong T, Li S, Chen X, Stang PJ. Proc Natl Acad Sci USA, 2019, 116: 6618–6623

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Shen Y, Shuhendler AJ, Ye D, Xu JJ, Chen HY. Chem Soc Rev, 2016, 45: 6725–6741

    Article  CAS  PubMed  Google Scholar 

  118. Bolze F, Jenni S, Sour A, Heitz V. Chem Commun, 2017, 53: 12857–12877

    Article  CAS  Google Scholar 

  119. Wang S, Wu W, Manghnani P, Xu S, Wang Y, Goh CC, Ng LG, Liu B. ACS Nano, 2019, 13: 3095–3105

    Article  CAS  PubMed  Google Scholar 

  120. Wu Y, Zhang D, Hu X, Peng R, Li J, Zhang X, Tan W. Angew Chem Int Ed, 2021, 60: 12569–12576

    Article  CAS  Google Scholar 

  121. Zhou Z, Liu J, Huang J, Rees TW, Wang Y, Wang H, Li X, Chao H, Stang PJ. Proc Natl Acad Sci USA, 2019, 116: 20296–20302

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Qin Y, Chen X, Gui Y, Wang H, Tang BZ, Wang D. J Am Chem Soc, 2022, 144: 12825–12833

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22171219, 22222112), the Innovation Talent Promotion Plan of Shaanxi Province for Science and Technology Innovation Team (2023-CX-TD-51) and the Fundamental Research Funds for the Central Universities.

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  1. State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, 710049, China

    Qian Feng, Rongrong Li, Tingting Gao & Mingming Zhang

  2. Department of Gastroenterology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China

    Dake Chu

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Feng, Q., Li, R., Gao, T. et al. Emissive metallacages for biomedical applications. Sci. China Chem. 66, 2447–2459 (2023). https://doi.org/10.1007/s11426-023-1672-4

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