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Tunable catalytic activity of FeWO4 nanomaterials for sensitive assays of pyrophosphate ion and alkaline phosphatase activity

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Abstract

Alkaline phosphatase (ALP) activity and pyrophosphate ion (PPi) levels are remarkable for the human body functions such as signal transduction pathways and metabolism. Current quantitative methods mainly focus on developing complicated organic substrates or employing unstable metal ions as signal-regulated medium. Herein, we have developed a facile hydrothermal method for preparing FeWO4 nanomaterials with intrinsic peroxidase-like activity and further confirmed that such a catalytic activity could be significantly enhanced by adjusting the size and oxygen vacancy content. More encouragingly, PPi can easily inhibit the catalytic activity of FeWO4, whereas orthophosphate ions (Pi) cannot. Therefore, we constructed an FeWO4-based colorimetric assay for sensing PPi by means of the classical 3,3′,5,5′-tetramethylbenzidine-peroxidase chromogenic reaction. A facile and reliable ALP activity assay was also designed and developed because of the logical regulation of the peroxidase-like activity of FeWO4 through the ALP-catalyzed hydrolysis of PPi into Pi. Based on the clear mechanism and mimetic-enzyme FeWO4-catalyzed amplification, the sensing system exhibited excellent performance and was able to evaluate ALP activity in real serum samples and screen for potential ALP inhibitors. The proposed mimetic enzyme-involved colorimetric assay provides an alternative pathway, and FeWO4 nanomaterials with excellent performance have great potential for further biosensing and biomedical applications.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21974132, 22034006, 21721003) and the Open Project of State Key Laboratory of Supramolecular Structure and Materials (sklssm2023021).

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Authors and Affiliations

  1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Xianqing Tang, Jinghuang Chen, Mengqian Zhang, Jian Sun & Xiurong Yang

  2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China

    Xianqing Tang, Jinghuang Chen & Xiurong Yang

  3. Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China

    Mengqian Zhang

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  1. Xianqing Tang
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  2. Jinghuang Chen
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  4. Jian Sun
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  5. Xiurong Yang
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Correspondence to Jian Sun or Xiurong Yang.

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Supporting information The supporting information is available online at https://chem.scichina.com and https://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Tunable catalytic activity of FeWO4 nanomaterials for sensitive assays of pyrophosphate ion and alkaline phosphatase activity

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Tang, X., Chen, J., Zhang, M. et al. Tunable catalytic activity of FeWO4 nanomaterials for sensitive assays of pyrophosphate ion and alkaline phosphatase activity. Sci. China Chem. 66, 1860–1868 (2023). https://doi.org/10.1007/s11426-023-1583-8

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  • DOI: https://doi.org/10.1007/s11426-023-1583-8

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