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Recent advances in radical-mediated fluorination through C–H and C–C bond cleavage

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Abstract

The C–H and C–C bonds are abundant in organic compounds, yet generally inert in chemical transformations. Therefore, direct functionalization of inert chemical bonds remains challenging. The fluorine-containing compounds are of special interest for their uses in medicinal chemistry. Direct fluorination of C–H and C–C bonds undoubtedly represents one of the most ideal and attractive approaches to incorporate fluorine atom into complex molecules. Herein, we summarize the recent advances in radical-mediated C–H and C–C bond fluorination. Three types of transformations are discussed: (1) direct C–H abstraction/fluorination of alkanes; (2) decarboxylative fluorination of alkyl carboxylic acids; (3) ring-opening fluorination.

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Acknowledgments

This work was supported by Soochow University, the National Natural Science Foundation of China (21402134), the Natural Science Foundation of Jiangsu Province (BK20140306), and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Authors and Affiliations

  1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China

    Hong Yan & Chen Zhu

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  1. Hong Yan
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  2. Chen Zhu
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Correspondence to Chen Zhu.

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Yan, H., Zhu, C. Recent advances in radical-mediated fluorination through C–H and C–C bond cleavage. Sci. China Chem. 60, 214–222 (2017). https://doi.org/10.1007/s11426-016-0399-5

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  • DOI: https://doi.org/10.1007/s11426-016-0399-5

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