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Associations of polychlorinated biphenyl and organochlorine pesticide exposure with hyperuricemia: modification by lifestyle factors

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Abstract

Recent research has reported positive associations of exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) with hyperuricemia. However, most of these studies have primarily focused on the individual effects of PCB/OCP exposure. We aimed to explore the associations of both individual and combined PCB/OCP exposure with hyperuricemia and examine whether such associations could be modified by lifestyle factors. The cross-sectional study recruited 2032 adults between March and May 2019 in Wuhan, China. Logistic regression and weighted quantile sum (WQS) regression were applied to explore the relationship of individual and combined PCB/OCP exposure with hyperuricemia, while considering the modified effects of lifestyle factors. Of the 2032 participants, 522 (25.7%) had hyperuricemia. Compared with the non-detected group, the detected groups of PCB153 and PCB180 exhibited a positive association with hyperuricemia, with OR (95% CIs) of 1.52 (1.22, 1.91) and 1.51 (1.20, 1.90), respectively. WQS regression showed that PCB/OCP mixture was positively associated with hyperuricemia (OR: 1.31, 95% CI: 1.08, 1.58). PCB153/PCB180 exposure, combined with an unhealthy lifestyle, has a significant additive effect on hyperuricemia. Overall, PCB/OCP mixture and individual PCB153/PCB180 exposure were positively associated with hyperuricemia. Adherence to a healthy lifestyle may modify the potential negative impact of PCBs/OCPs on hyperuricemia.

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The data are available from the corresponding author upon reasonable request.

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Funding

This study was supported by the National Natural Science Foundation of China (82003479, 82073660), Hubei Provincial Natural Science Foundation of China (2023AFB663), and China Postdoctoral Science Foundation (2019M662646, 2020T130220).

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Authors and Affiliations

  1. Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China

    Gaojie Fan, Qing Liu, Jianing Bi, Qing Fang, Xiya Qin, Mingyang Wu, Youjie Wang & Lulu Song

  2. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

    Gaojie Fan, Qing Liu, Jianing Bi, Qing Fang, Xiya Qin, Mingyang Wu, Surong Mei, Youjie Wang & Lulu Song

  3. Health Management Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

    Yongman Lv & Zhengce Wan

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  1. Gaojie Fan
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  2. Qing Liu
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  3. Jianing Bi
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  4. Qing Fang
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  10. Zhengce Wan
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  11. Lulu Song
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Contributions

Lulu Song designed the study and reviewed the manuscript. Gaojie Fan, Lulu Song, Qing Liu, Jianing Bi, Qing Fang, Xiya Qin, Mingyang Wu, Yongman Lv, Surong Mei, and Zhengce Wan conducted the study. Youjie Wang reviewed the manuscript. Gaojie Fan analyzed the data and wrote the first draft of the manuscript. All authors provided important intellectual contributions, edited the manuscript, and ensured its final contents.

Corresponding author

Correspondence to Lulu Song.

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The study protocol was approved by the ethics committees of Wuhan Tongji Hospital and Tongji Medical College, Huazhong University of Science and Technology.

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The authors declare no competing interests.

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Fan, G., Liu, Q., Bi, J. et al. Associations of polychlorinated biphenyl and organochlorine pesticide exposure with hyperuricemia: modification by lifestyle factors. Environ Sci Pollut Res 30, 106562–106570 (2023). https://doi.org/10.1007/s11356-023-29938-z

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