Abstract
Arsenic (As) is known for its carcinogenic and hepatorenal toxic effects causing serious health problems in human beings. Turmeric (Curcuma longa L.) extracted curcumin (Cur) is a polyphenolic antioxidant which has ability to combat hazardous environmental toxicants. This study (28 days) was carried out to investigate the therapeutic efficacy of different doses of Cur (Cur: 80, 160, 240 mg kg−1) against the oxidative damage in the liver and kidney of male rats caused by sodium arsenate (Na3AsO4) (10 mg L−1). As exposure significantly elevated the values of organ index, markers of hepatic injury (i.e., alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)) and renal functions (i.e., total bilirubin, urea and creatinine, total cholesterol, total triglycerides, and lipid peroxidation malondialdehyde (MDA)). Moreover, different antioxidant markers such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities in the liver and kidney tissues were reduced after As-induced toxicity. However, Na3AsO4 induced histopathological changes in various organs were minimized after the treatment with Cur. The alleviation effect of Cur was dosage dependent with an order of 240>160>80 mg kg−1. The oral administration of Cur prominently alleviated the As-induced toxicity in liver and kidney tissues by reducing lipid peroxidation, ALT, AST, ALP, total bilirubin, urea, creatinine, total cholesterol, total triglycerides, and low-density lipoproteins (LDL). In addition, Cur being an antioxidant improved defense system by enhancing activities of SOD, CAT, GPx, and GR. Overall, the findings explain the capability of Cur to counteract the oxidative alterations as well as hepatorenal injuries due to As intoxication.
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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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The authors highly acknowledge the Department of Chemistry and Faculty of Veterinary Sciences at The University of Agriculture, Faisalabad, for providing experimental materials and analyzing the samples.
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Conceptualization: Ali Hassan, Muhammad Kamran, Shah Fahad; data curation: Anam Ishaq, Muhammad Riaz, Aasma Parveen; formal analysis: Anam Ishaq, Huma Gulzar; Muhammad Sohaib Chattha, Noman Walayat; investigation: Anam Ishaq, Huma Gulzar; methodology: Anam Ishaq, Sana Fatima; resources: Muhammad Riaz, Ali Hassan, Muhammad Kamran; writing—original draft: Anam Ishaq, Huma Gulzar, Muhammad Kamran; writing—review and editing: Shah Fahad, Muhammad Sohaib Chattha, Sobia Afzal, Muhammad Kamran; supervision: Shah Fahad, Ali Hassan
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Ishaq, A., Gulzar, H., Hassan, A. et al. Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats. Environ Sci Pollut Res 28, 66313–66326 (2021). https://doi.org/10.1007/s11356-021-15695-4
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DOI: https://doi.org/10.1007/s11356-021-15695-4