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Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways

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Abstract

The presented study investigates the effects of morin against toxicity induced by acrylamide (ACR) in the brains of Sprague Dawley rats. In this study, neurotoxicity was induced by orally administering 38.27 mg/kg/b.w ACR to rats through gastric gavage for 10 days. Morin was administered at the same time and at different doses (50 and 100 mg/kg/b.w) with ACR. Biochemical and Western blot analyses showed that ACR increased malondialdehyde (MDA), p38α mitogen-activated protein kinase (p38α MAPK), nuclear factor kappa-B (NF-κB), tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), p53, caspase-3, bcl-2 associated X protein (Bax), Beclin-1, light chain 3A (LC3A), and light chain 3B (LC3B) levels and decreased those of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), b-cell lymphoma-2 (Bcl-2), mammalian target of rapamycin (mTOR), phosphoinositide 3-kinase (PI3K), and protein kinase B (Akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. On the other hand, it was determined that morin positively affected the levels of these markers by displaying antioxidant, anti-inflammatory, anti-apoptotic, and anti-autophagic properties and had a protective effect on ACR-induced neurotoxicity. As a result, morin is an effective substance against brain damage caused by ACR, yet further studies are needed to use it effectively.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, 25240, Erzurum, Turkey

    Cihan Gur, Fatih Mehmet Kandemir, Sefa Kucukler, Ozge Kandemir & Mustafa Ileriturk

  2. Department of Molecular Biology and Genetics, Faculty of Science and Literature, Bingol University, Bingol, Turkey

    Ekrem Darendelioglu

  3. Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, Bingol, Turkey

    Cuneyt Caglayan

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  1. Cihan Gur
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  2. Fatih Mehmet Kandemir
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CG: Writing – original draft, writing – review and editing, methodology, and formal analysisFMK: Writing – original draft, writing – review and editing, methodology, project administration, formal analysis, and conceptualizationED: Methodology and investigationCC: Methodology and investigationSK: Methodology and data curationOK: Investigation and data curationMI: Methodology and Investigation

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Correspondence to Cihan Gur or Fatih Mehmet Kandemir.

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Gur, C., Kandemir, F.M., Darendelioglu, E. et al. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environ Sci Pollut Res 28, 49808–49819 (2021). https://doi.org/10.1007/s11356-021-14049-4

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