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Bio-indicators in cadmium toxicity: Role of HSP27 and HSP70

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Abstract

Heat shock proteins (HSPs) are a family of proteins that are expressed by cells in reply to stressors. The changes in concentration of HSPs could be utilized as a bio-indicator of oxidative stress caused by heavy metal. Exposure to the different heavy metals may induce or reduce the expression of different HSPs. The exposure to cadmium ion (Cd2+) could increase HSP70 and HSP27 over 2- to 10-fold or even more. The in vitro and in vivo models indicate that the HSP70 family is more sensitive to Cd intoxication than other HSPs. The analyses of other HSPs along with HSP70, especially HSP27, could also be useful to obtain more accurate results. In this regard, this review focuses on examining the literature to bold the futuristic uses of HSPs as bio-indicators in the initial assessment of Cd exposure risks in defined environments.

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Funding

The authors appreciatively acknowledge the support and assistance provided by Mashhad University of Medical Sciences.

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Authors and Affiliations

  1. Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Ehsan Taghavizadeh Yazdi, Fahimeh Nourbakhsh & Seyed Hadi Mousavi

  2. Department of Biology, Payame Noor University, Tehran, Iran

    Mohammad Sadegh Amiri

  3. Department of Plant Pathology, University of Kentucky, Lexington, KY, 40506, USA

    Mostafa Rahnama

  4. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Fatemeh Forouzanfar

  5. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Fatemeh Forouzanfar

  6. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Hadi Mousavi

Authors
  1. Mohammad Ehsan Taghavizadeh Yazdi
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  2. Mohammad Sadegh Amiri
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  3. Fahimeh Nourbakhsh
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  4. Mostafa Rahnama
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  5. Fatemeh Forouzanfar
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  6. Seyed Hadi Mousavi
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Contributions

ME.TY and MS.A conceived of the presented idea, data extraction, and analysis. F.N. and F.F. draw the shapes and developed the contents. ME.TY, M.R., and SH.M authors contributed to the final version of the manuscript. SH.M. supervised the project. All authors discussed the results and contributed to the final manuscript.

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Correspondence to Seyed Hadi Mousavi.

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Taghavizadeh Yazdi, M.E., Amiri, M.S., Nourbakhsh, F. et al. Bio-indicators in cadmium toxicity: Role of HSP27 and HSP70. Environ Sci Pollut Res 28, 26359–26379 (2021). https://doi.org/10.1007/s11356-021-13687-y

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