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Matlodextrin-cinnamon essential oil nanoformulation as a potent protective against titanium nanoparticles-induced oxidative stress, genotoxicity, and reproductive disturbances in male mice

  • Research Article
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11 April 2024 Editor's Note: Readers are alerted that the concerns have been raised with this article. Editorial action will be taken as appropriate once this matter is resolved and all parties have been given an opportunity to respond in full.

A Correction to this article was published on 14 September 2022

This article has been updated

Abstract

Recently, bio-nanofabrication becomes one of the widest methods for synthesizing nanoparticles (NPs); however, there is scanty literature exploring the toxicity of these green NPs against living organisms. This study aimed to evaluate the potential protective role of encapsulated cinnamon oil (ECO) against titanium oxide nanoparticle (TiO2NP)–induced oxidative stress, DNA damage, chromosomal aberration, and reproductive disturbances in male mice. Sixty male Balb/c mice were distributed into six groups treated orally for 3 weeks and included control group, TiO2NP-treated group (25 mg/kg b.w), ECO at low or high dose–treated groups (50 or 100 mg/kg b.w), and the groups that received TiO2NPs plus ECO at a low or high dose. The results of GC-MS revealed the isolation of 21 compounds and the majority was cinnamaldehyde. The average size zeta potential of TiO2NPs and ECO were 28.9 and 321 nm and −33.97 and −17.35 mV, respectively. TiO2NP administration induced significant changes in liver and kidney function, decreased antioxidant capacity, and increased oxidative stress markers in liver and kidney, DNA damage in the hepatocytes, the number of chromosomal aberrations in the bone marrow and germ cells, and sperm abnormalities along with histological changes in the liver, kidney, and testis. Co-administration of TiO2NPs and ECO could alleviate these disturbances in a dose-dependent manner. It could be concluded that ECO is a promising and safe candidate for the protection against the health hazards of TiO2NPs.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Code availability

The codes used during the current study are available from the corresponding author on reasonable request.

Change history

  • 11 April 2024

    Editor's Note: Readers are alerted that the concerns have been raised with this article. Editorial action will be taken as appropriate once this matter is resolved and all parties have been given an opportunity to respond in full.

  • 14 September 2022

    A Correction to this paper has been published: https://doi.org/10.1007/s11356-022-23031-7

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Funding

This study was supported by the Deanship of Scientific Research (DSR) at the University of Jeddah, Jeddah, Saudi Arabia, grant no. UJ-02-047-DR.

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Authors and Affiliations

  1. Department of Biology, College of Science and Arts at Khulis, University of Jeddah, Jeddah, Saudi Arabia

    Asmaa S. Salman & Salwa S. Bawazir

  2. Genetic and Cytology Department, National Research Center, Dokki, Cairo, Egypt

    Asmaa S. Salman & Turki M. Al-Shaikh

  3. Department of Food Toxicology & Contaminants, National Research Center, Dokki, Cairo, Egypt

    Zeinab K. Hamza, Aziza A. El-Nekeety & Mosaad A. Abdel-Wahhab

  4. Department of Medical Pathology, National Research Center, Dokki, Cairo, Egypt

    Nabila S. Hassan

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  1. Asmaa S. Salman
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Contributions

This work was carried out through the collaboration of all authors. Authors Asmaa S. Salman, Turki M. Al-Shaikh, and Salwa S. Bawazir carried out the experimental work and managed the literature searches and the genetic part of the work. Author Aziza A. EL-Nekeety and Zeinab K. Hamza prepared and characterized the nanoparticles and carried out the biochemical analysis. Author Nabila S. Hassan carried out the histological part. Author Mosaad A. Abdel-Wahhab wrote the protocol, managed the project, managed the analyses of the study, performed the statistical analysis, and wrote the final draft of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Mosaad A. Abdel-Wahhab.

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The protocol of the current study was approved by the ethics Animal Care and Use Committee of the University of Jeddah (approval # UJ-02-047-DR)

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Salman, A.S., Al-Shaikh, T.M., Hamza, Z.K. et al. Matlodextrin-cinnamon essential oil nanoformulation as a potent protective against titanium nanoparticles-induced oxidative stress, genotoxicity, and reproductive disturbances in male mice. Environ Sci Pollut Res 28, 39035–39051 (2021). https://doi.org/10.1007/s11356-021-13518-0

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