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Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken’s liver

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Abstract

The effect of selenium on excessive fatty acid–induced apoptosis and abnormal amino acid metabolism in the liver is well known, because it is an important site in the fatty acid metabolism pathway. However, the protective role of nano-elemental selenium (nano-Se) supplementation against hexavalent chromium (K2Cr2O7)–induced abnormal fatty acid metabolism has not been evaluated yet. Therefore, we conducted chicken experiments with different nano-Se supplementation doses to investigate the role of nano-Se against Cr(VI)-induced adverse effects. For this purpose, a total of 120 1-day-old chicks were randomly divided into control group, Cr(VI)-exposed group, protection group, treatment group, prevention group, and nano-Se control group. The results of RT-qPCR showed that the nano-Se supplementation notably downregulated (P < 0.01) the messenger RNA (mRNA) expression levels of fatty acid synthase (FASN), whereas nano-Se supplementation significantly upregulated (P < 0.01) the mRNA expression level of acyl-coenzyme A oxidase 1 (ACOX1) in chicken’s liver at day 35 of the experiment. Similar results were further verified by western blot analysis. Moreover, nano-Se supplementation significantly enhanced and reduced the antibody expression levels of ACOX1 and FASN in immunohistochemical analysis, respectively. Thus, finally, it was concluded that nano-Se can alleviate K2Cr2O7-induced abnormal fatty acid metabolism in chicken’s liver.

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Funding

This study was supported by the National Key R&D Program of China (2016YFD0501208), National Nature Science Foundation of China (No. 30700588), and Hubei Provincial Natural Science Foundation of China (Grant No. 2014CFB244).

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Authors and Affiliations

  1. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China

    Min Luo, Jialu Zhang, Lihong Zhang, Khalid Mehmood, Jinhuan Jiang, Niya Zhang & Donghai Zhou

  2. College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, People’s Republic of China

    Shucheng Huang

  3. University College of Veterinary and Animal Sciences, Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan

    Khalid Mehmood

Authors
  1. Min Luo
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  2. Shucheng Huang
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  3. Jialu Zhang
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  4. Lihong Zhang
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  5. Khalid Mehmood
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  6. Jinhuan Jiang
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  7. Niya Zhang
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  8. Donghai Zhou
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Contributions

M.L. and D.Z. were responsible for the study conception and design. M.L., D.Z., S.H., J.Z., L.Z., K.M., J.J., and N.Z. were involved in the drafting of the manuscript.

Corresponding author

Correspondence to Donghai Zhou.

Ethics declarations

All the experiments were performed after the approval of the Institutional Animal Welfare and Research Ethics Committee of Huazhong Agricultural University, Wuhan, China.

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The authors declare that they have no conflict of interest.

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Responsible editor: Philippe Garrigues

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Luo, M., Huang, S., Zhang, J. et al. Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken’s liver. Environ Sci Pollut Res 26, 21828–21834 (2019). https://doi.org/10.1007/s11356-019-05397-3

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  • DOI: https://doi.org/10.1007/s11356-019-05397-3

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